Results 11 to 20 of about 29,837,368 (252)

Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens. [PDF]

PLoS ONE, 2010
BACKGROUND: Hypoxia inducible factor (HIF)-1 is the key transcriptional factor involved in the adaptation process of cells and organisms to hypoxia. Recent findings suggest that HIF-1 plays also a crucial role in inflammatory and infectious diseases ...
Nadine Werth, Christiane Beerlage, Christian Rosenberger, Amir S Yazdi, Markus Edelmann, Amro Amr, Wanja Bernhardt, Christof von Eiff, Karsten Becker, Andrea Schäfer, Andreas Peschel, Volkhard A J Kempf   +11 more
doaj   +3 more sources

HIF-1-dependent stromal adaptation to ischemia mediates in vivo tumor radiation resistance

, 2011
Purpose: Hypoxia-inducible factor 1 (HIF-1) promotes cancer cell survival and tumor progression. The specific role played by HIF-1 and tumor - stromal interactions toward determining tumor resistance to radiation treatment remains undefined. We applied a
David L. Schwartz (3809851), James Bankson (369593), Luc Bidaut (17153986)   +2 more
core   +5 more sources

Factor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1α-mediated apoptosis. [PDF]

, 2011
BACKGROUND: Clear cell renal cell carcinoma (CCRCC) is the commonest form of kidney cancer. Up to 91% have biallelic inactivation of VHL, resulting in stabilisation of HIF-α subunits.
T Bhattacharyya, M A Esteban, S Kiriakidis, Kiriakidis, Serafim, Kiriakidis, S, P H Maxwell, Barod, R, M N Khan, Connor, T, Andrikopoulos, P, Bhattacharyya, T, Ashcroft, M, R Barod, T Connor, M Ashcroft, Khan, MN, Maxwell, PH, Esteban, MA, P Andrikopoulos   +18 more
core   +2 more sources

Adaptation to HIF-1 deficiency by upregulation of the AMP/ATP ratio and phosphofructokinase activation in hepatomas [PDF]

, 2011
Background HIF-1 deficiency has marked effects on tumour glycolysis and growth. We therefore investigated the consequences of HIF-1 deficiency in mice, using the well established Hepa-1 wild-type (WT) and HIF-1β-deficient (c4) model.
Golinska Monika, Chung Yuen-Li, Stubbs Marion, Airley Rachel E, Troy Helen, Williams, Kaye J., Williams, KJ, Mayr, Manuel, McSheehy, PM, Monika Golinska, Rachel E Airley, Yin, Xiaoke; id_orcid, Stubbs, M, Xiaoke Yin, Airley, Rachel E., Lucy Ly, Troy, H, Perumal Meg, Adrian L Harris, Eric O Aboagye, Mayr, Manuel; id_orcid, Golinska, Monika, Aboagye, Eric O., Kaye J Williams, Yuen-Li Chung, Manuel Mayr, Yin, X, Chung, Yuen Li, John Latigo, McSheehy, Paul M., Chung, YL, Golinska, M, Griffiths John R, Ly Lucy, Helen Troy, Chung, Yuen-Li, Mayr, M, Stubbs, Marion, Latigo John, Perrett, D, Perrett David, John R Griffiths, Aboagye Eric O, Harris, AL, Perrett, David, Griffiths, John R., Perumal, M, Williams Kaye J, Latigo, J, Perumal, Meg, Mayr Manuel, Griffiths, JR, Ly, Lucy, Airley, RE, Marion Stubbs, McSheehy Paul M, David Perrett, Ly, L, Yin, Xiaoke, Troy, Helen, Aboagye, EO, Latigo, John, Meg Perumal, Harris Adrian L, Yin Xiaoke, Harris, Adrian L., Paul M McSheehy   +66 more
core   +2 more sources

Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner [PDF]

, 2014
The transcription factor HIF-1α is essential for cells to rapidly adapt to low oxygen levels (hypoxia). HIF-1α is frequently deregulated in cancer and correlates with poor patient prognosis.
Anja Bremm, Moniz, Sonia, David Komander, Bremm, Anja, Komander, David, Sonia Rocha, Mader, Julia, Rocha, Sonia, Sonia Moniz, Julia Mader   +9 more
core   +1 more source

A long-term "memory" of HIF induction in response to chronic mild decreased oxygen after oxygen normalization [PDF]

, 2007
Background Endothelial dysfunction (ED) is functionally characterized by decreased vasorelaxation, increased thrombosis, increased inflammation, and altered angiogenic potential, has been intimately associated with the progression and severity of ...
Green Dixy E, Ihnat Michael A, Green, Dixy E., Satyendra S Shenoy, Shenoy Satyendra S, Green DE, Thorpe JE, Ceriello Antonio, Kamat CD, Ceriello, Antonio, Antonio Ceriello, Shenoy, Satyendra S, Dixy E Green, Kamat Chandrashekhar D, Linda A Warnke, Warnke, Linda A., Warnke Linda A, Shenoy SS, Chandrashekhar D Kamat, Michael A Ihnat, Warnke LA, Kamat, Chandrashekhar D., Ihnat, Michael A., Ihnat M.A., Thorpe, Jessica E, Thorpe Jessica E, Jessica E Thorpe   +26 more
core   +2 more sources

Responses to hypoxia via mTOR : role in endothelial cell proliferation and HIF-1[alpha] stabilization [PDF]

, 2005
Ischemic cardiovascular disease and cancer are life-threatening disorders in human mortality. Intensive studies on the etiology of and therapeutics for the diseases are ongoing.
Li, Weimin
core   +1 more source

Hypoxia-induced chemoresistance in cancer cells: The role of not only HIF-1

Biomedical Papers, 2015
Background: The aim of this review is to provide the information about molecular basis of hypoxia-induced chemoresistance, focusing on the possibility of diagnostic and therapeutic use.
Helena Doktorova, Jan Hrabeta, Mohamed Ashraf Khalil, Tomas Eckschlager   +3 more
doaj   +1 more source

HIF-1α, a novel piece in the NF-κB puzzle [PDF]

, 2015
Hypoxia, or low oxygen availability, is an important physiological stimulus for multicellular organisms. Molecularly, hypoxia induces a transcriptional programme directed at restoration of oxygen homeostasis and cellular survival.
Bandarra, Daniel, Rocha, Sonia
core   +1 more source

EGCG attenuated spinal cord injury by inhibiting ferroptosis via activation of HMOX1 expression and suppression of HIF-1 signaling pathway [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Epigallocatechin gallate (EGCG) exhibits various biological effects, including antiviral, anti-inflammatory, cardioprotective, and lipid-regulating properties. This study aims to investigate the therapeutic effects and mechanisms of EGCG in
Han Yang, Fei Ye, Liuxu Chen, Linyu Yang, Jianping Kang   +4 more
doaj   +1 more source