EGCG attenuated spinal cord injury by inhibiting ferroptosis via activation of HMOX1 expression and suppression of HIF-1 signaling pathway [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Epigallocatechin gallate (EGCG) exhibits various biological effects, including antiviral, anti-inflammatory, cardioprotective, and lipid-regulating properties. This study aims to investigate the therapeutic effects and mechanisms of EGCG in
Han Yang +4 more
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Cellular & Molecular Biology Letters, 2022 The hypoxia-inducible factors (HIF) are transcription factors that activate the adaptive hypoxic response when oxygen levels are low. The HIF transcriptional program increases oxygen delivery by inducing angiogenesis and by promoting metabolic ...
Maciej Jaśkiewicz +9 more
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Targeting PCOS-related inflammation with bioactive compounds of Syzygium polyanthum (Wight) Walp. leaves extract: An in silico study [PDF]
Journal of Pharmacy & Pharmacognosy ResearchContext: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder affecting reproductive-aged women, often associated with chronic inflammation.
Renny Aditya, Wirdatun Nafisah
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HIF-1-Independent Mechanisms Regulating Metabolic Adaptation in Hypoxic Cancer Cells
Cells, 2021 In solid tumours, cancer cells exist within hypoxic microenvironments, and their metabolic adaptation to this hypoxia is driven by HIF-1 transcription factor, which is overexpressed in a broad range of human cancers. HIF inhibitors are under pre-clinical
Shen-Han Lee +2 more
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Molecular cloning and expression analysis of hypoxia inducible factor 1α in tongue sole, Cynoglossus semilaevis (Actinopterygii: Pleuronectiformes: Cynoglossidae), subjected to acute hypoxia [PDF]
Acta Ichthyologica et Piscatoria, 2013 Background. Hypoxia-inducible factor-1α (HIF-1α), a subunit of the HIF-1 protein, plays a key role in the regulation of genes involved in hypoxia physiological response.
Z.T. Qi +5 more
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Research Advance of Hypoxia-regulated miR-210 in Cancer
Zhongliu Fangzhi Yanjiu, 2018 The uncontrolled proliferation of tumor cells and the relative deficiency of the internal neovascularization network lead to insufficient oxygen supply.
CAO Zheng, FENG Lin, FENG Xiaoli
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HIF-1-Dependent Induction of β3 Adrenoceptor: Evidence from the Mouse Retina
Cells, 2022 A major player in the homeostatic response to hypoxia is the hypoxia-inducible factor (HIF)-1 that transactivates a number of genes involved in neovessel proliferation in response to low oxygen tension.
Rosario Amato +10 more
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Hypoxia-Inducible Factor 1-Related Diseases and Prospective Therapeutic Tools
Journal of Pharmacological Sciences, 2004 Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. HIF-1 regulates the expressions of the proteins that increase oxygen delivery, which enables cells to survive in oxygen-deficient ...
Jong-Wan Park +2 more
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Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens. [PDF]
PLoS ONE, 2010 BACKGROUND: Hypoxia inducible factor (HIF)-1 is the key transcriptional factor involved in the adaptation process of cells and organisms to hypoxia. Recent findings suggest that HIF-1 plays also a crucial role in inflammatory and infectious diseases ...
Nadine Werth +11 more
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Journal of Neuroinflammation, 2007 Background Neuroinflammation has been implicated in various brain pathologies characterized by hypoxia and ischemia. Astroglia play an important role in the initiation and propagation of hypoxia/ischemia-induced inflammation by secreting inflammatory ...
Mojsilovic-Petrovic Jelena +5 more
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