Results 21 to 30 of about 126,163 (218)
The hypoxia response pathway promotes PEP carboxykinase and gluconeogenesis in C. elegans
Nature Communications, 2022 Actively dividing cells, including some cancers, rely on aerobic glycolysis rather than oxidative phosphorylation to generate energy, a phenomenon termed the Warburg effect. Constitutive activation of the Hypoxia Inducible Factor (HIF-1), a transcription
Mehul Vora +8 more
doaj +1 more source
Fluid membrane vesicles in confinement
New Journal of Physics, 2012 We numerically study the morphology of fluid membrane vesicles with the prescribed volume and surface area in confinement. For spherical confinement, we observe axisymmetric invaginations that transform into ellipsoidal invaginations when the area of the
Osman Kahraman +2 more
doaj +1 more source
The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans.
PLoS ONE, 2009 During normal development or during disease, animal cells experience hypoxic (low oxygen) conditions, and the hypoxia-inducible factor (HIF) transcription factors implement most of the critical changes in gene expression that enable animals to adapt to ...
Yi Zhang +4 more
doaj +1 more source
Intracellular pathogen Leishmania donovani activates hypoxia inducible factor-1 by dual mechanism for survival advantage within macrophage. [PDF]
PLoS ONE, 2012 Recent evidence established a crucial role for mammalian oxygen sensing transcription factor hypoxia inducible factor-1 (HIF-1) in innate immunity against intracellular pathogens.
Amit Kumar Singh +4 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
HIF-1 signaling: A key orchestrator of cancer radioresistance
Radiation Medicine and Protection, 2020 Hypoxia is a big roadblock for cancer radiotherapy, in which the hypoxia-inducible factor (HIF-1) creates a microenvironment and cancer cells’ intrinsic signaling networks conferring radioresistance to cancers.
Ruixue Huang, Ping-Kun Zhou
doaj +1 more source
1, 9-Pyrazoloanthrones downregulate HIF-1α and sensitize cancer cells to cetuximab-mediated anti-EGFR therapy. [PDF]
PLoS ONE, 2010 Cetuximab, a monoclonal antibody that blocks the epidermal growth factor receptor (EGFR), is currently approved for the treatment of several types of solid tumors.
Yang Lu, Xinqun Li, Haiquan Lu, Zhen Fan
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source