Results 161 to 170 of about 57,100 (255)

Discovery of NKT2152, a Potent and Selective HIF-2α Inhibitor with Favorable Pharmacokinetic Properties. [PDF]

ACS Med Chem Lett
Fu J, He Y, Lu J, Wei H, Sun W, Geng J, Liu K, Liu JJ, Liu Z, Wang K, Xiao J, Gao Z, Lou Y.   +12 more
europepmc   +1 more source

Transcriptome and proteome analyses reveal divergent adaptive strategies in nasopharyngeal epithelial cells and nasopharyngeal carcinoma cells under ultra‐low background radiation

Deep Underground Science and Engineering, EarlyView.
This study demonstrates that the ultra‐low background radiation environment in deep underground laboratories significantly inhibits the proliferation of both normal nasopharyngeal epithelial cells (HNEPC) and nasopharyngeal carcinoma cells (HNE‐1) cells, with malignant cells exhibiting higher sensitivity.
Yuhao Zou, Qi Wu, Jirui Wen, Ling Wang, Can Li, Juan Cheng, Tengfei Ma, Chuhan Lv, Shixi Liu, Mingzhong Gao, Ruihua Dong, Jianxiong Zhang, Jingxuan Wu, Heping Xie, Jiang Wu, Jifeng Liu   +15 more
wiley   +1 more source

A Comprehensive Review of Fault‐Current Limiter Technologies for Smart and Resilient Power Systems

Energy Science &Engineering, EarlyView.
This review compares superconducting, solid‐state, and hybrid fault‐current limiters (FCLs) for modern alternating current, direct current, and hybrid grids. It shows that optimal FCL selection depends on fault characteristics, network configuration, voltage level, protection coordination, and resilience requirements rather than on a universally ...
Abdelrahman Farghly, Eslam Essam, Hilmy Awad, Samia Abdelfatah, Walid Issa, Abdallah M. Hamada   +5 more
wiley   +1 more source

Corrigendum to Genome-wide CRISPR screen identifies a cytokine-enhancer circuit driving HIF-2α activation in renal cancer. [PDF]

J Clin Invest
Fang J, Simon JM, Wang T, Gao Y, Bi X, Hu L, Liao C, Zhang C, Adachi Y, Zhou J, Liu H, Liang Q, Nathan JA, Mani R, Brugarolas J, Zhang Q.   +15 more
europepmc   +1 more source

Shikonin Promotes Apoptosis in Multiple Myeloma Cells Through the PKM2‐AMPK‐PGC1α Metabolic Axis

Journal of Clinical Laboratory Analysis, EarlyView.
High PKM2 expression in MM is associated with a poor prognosis. Shikonin represents a promising PKM2‐targeted agent for MM therapy, offering a unique metabolic intervention strategy to improve drug resistance, bone disease, and the immune microenvironment. ABSTRACT Background Multiple myeloma (MM) is an incurable plasma malignancy.
Fengping Peng, Yu Gao, Ziqi Zhang, Ling Deng, Honglei Liu, Xiaowei Liang, Chunyan Liu, Rong Fu   +7 more
wiley   +1 more source

Targeting p300/CBP destabilizes HIF-2α and suppresses tumor growth in cell and animal models of clear cell renal cell carcinoma. [PDF]

Cancer Lett
Fazliyeva R, Matveev A, Smetanin R, Fedorov I, Cai KQ, Kutikov A, Uzzo RG, Andrews A, Makhov P, Kolenko VM.   +9 more
europepmc   +1 more source

Proteomic and Metabolomic Profiling Reveal Mitochondrial Transplantation–Mediated Reprogramming in Gastric Cancer Cells

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Mitochondria provide multiple functions for cellular physiology. Transplantation of mitochondria isolated from gastric epithelial cells GES‐1 reducing the malignancy of gastric cancer cells AGS was previously reported. To elucidate the underlying mechanisms, TMT‐based proteomic analysis coupling ingenuity pathway software prediction revealed ...
Ping‐Chen Chen, Chen‐Kai Liu, Ching‐Chung Tsai, Erna Sulistyowati, Fu‐An Li, Chung‐Jung Liu, Deng‐Chyang Wu, Shih‐Hsuan Chou, Fu‐Chen Kuo, Bin Huang   +9 more
wiley   +1 more source

Author Correction: Casdatifan shows durable response linked to HIF-2α biology in kidney cancer. [PDF]

Nature
Choueiri TK, Merchán J, Patnaik A, Drakaki A, Rini BI, Rha SY, Lee JL, Ornstein MC, Kumar R, Hwang C, Shao Y, Park SH, Barata PC, McGregor BA, Foster P, Chen J, Eisen M, Cole H, Weeder B, Guan Y, Singh J, Kaplan A, Cho S, Markus R, Kabbarah O, McKay RR.   +25 more
europepmc   +1 more source

Rhaponticin Blocks Glycolysis‐Mediated Histone Lactylation to Suppress Tongue Squamous Cell Carcinoma via HIF‐1α Activity Inhibition

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Tongue squamous cell carcinoma (TSCC) often develops therapeutic resistance. Metabolic reprogramming, particularly the glycolysis/lactate/histone lactylation axis, is a critical driver of tumor progression and therapy resistance. This study investigated the anti‐tumor mechanism of Rhaponticin (Rha), focusing on the metabolic/epigenetic axis ...
Yuan Wu, Liang‐Liang Yao, Lin Jiang, Zhi‐Yi Fang, Jia‐Jun Zhu, Yi‐Sen Shao, Wen‐Juan Wang, Xiao‐Wen Wan   +7 more
wiley   +1 more source

UBE2M deficiency in alveolar macrophages promotes emphysema through HIF-2α/MMP12 axis. [PDF]

Chin Med J Pulm Crit Care Med
Li Z, Guo D, Wang Y, Chen H, Li N, Dong L, Xu X, Zhao Y, Sun Y, Ying S, Li W, Zhou J, Chen Z.   +12 more
europepmc   +1 more source