Results 31 to 40 of about 163,557 (294)

Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data. [PDF]

PLoS Genetics, 2010
High-altitude hypoxia (reduced inspired oxygen tension due to decreased barometric pressure) exerts severe physiological stress on the human body. Two high-altitude regions where humans have lived for millennia are the Andean Altiplano and the Tibetan ...
Abigail Bigham, Marc Bauchet, Dalila Pinto, Xianyun Mao, Joshua M Akey, Rui Mei, Stephen W Scherer, Colleen G Julian, Megan J Wilson, David López Herráez, Tom Brutsaert, Esteban J Parra, Lorna G Moore, Mark D Shriver   +13 more
doaj   +1 more source

Metabolomics reveals potential plateau adaptability by regulating inflammatory response and oxidative stress-related metabolism and energy metabolism pathways in yak

Journal of Animal Science and Technology, 2022
Species are facing strong selection pressures to adapt to inhospitable high-altitude environments. Yaks are a valuable species and an iconic symbol of the Qinghai-Tibet Plateau.
Meizhou Huang, Xin Zhang, Wenjun Yan, Jingjing Liu, Hui Wang   +4 more
doaj   +1 more source

Development and validation of a machine learning based early warning scoring system for high altitude polycythemia

Frontiers in Public Health
BackgroundHigh-altitude polycythemia (HAPC) lacks a lifestyle-focused risk-stratification tool among lifelong high-altitude residents. Here we aimed to develop and validate a novel machine-learning predictive scoring system for HAPC using readily ...
Yangzong Suona, Yangzong Suona, Zhuoga Danzeng, Zhuoga Danzeng, Luobu Gesang, Luobu Gesang, Luobu Gesang, Luobu Gesang, Panduo Zhuoma, Yangjin Baima, Zhuoma Pubu, Wangjie Suolang, Bai Ci, Bai Ci, Ju Huang, Ju Huang, Quzong Zhaxi, Quzong Zhaxi, Binyun Liu, Binyun Liu, Rui Zhang, Rui Zhang, Quzhen Gesang, Quzhen Gesang, Qiangba Dingzeng, Qiangba Dingzeng, Zhuoga Baima, Zhuoga Baima   +27 more
doaj   +1 more source

Metagenome and metabolome insights into the energy compensation and exogenous toxin degradation of gut microbiota in high-altitude rhesus macaques (Macaca mulatta)

npj Biofilms and Microbiomes, 2023
There have been many reports on the genetic mechanism in rhesus macaques (RMs) for environmental adaptation to high altitudes, but the synergistic involvement of gut microbiota in this adaptation remains unclear.
Junsong Zhao, Yongfang Yao, Diyan Li, Wei Zhu, Hongtao Xiao, Meng Xie, Ying Xiong, Jiayun Wu, Qingyong Ni, Mingwang Zhang, Huailiang Xu   +10 more
doaj   +1 more source

Developmental adaptation to high altitude hypoxia [PDF]

International Journal of Biometeorology, 1977
Experimental studies on animals and humans exposed to hypoxic stress have been reviewed. These data suggest that the influence of hypoxic stress, and the organism's response to it, are greater during growth than during adulthood. The organism's responses include alterations in the quantity and size of the alveolar units of the lungs, enlargement of the
openaire   +3 more sources

Hippocampal adaptation to high altitude: a neuroanatomic profile of hippocampal subfields in Tibetans and acclimatized Han Chinese residents

Frontiers in Neuroanatomy, 2022
The hippocampus is highly plastic and vulnerable to hypoxia. However, it is unknown whether and how it adapts to chronic hypobaric hypoxia in humans.
Lianqing Zhang, Lianqing Zhang, Jinli Meng, Jinli Meng, Hailong Li, Hailong Li, Mengyue Tang, Mengyue Tang, Zan Zhou, Xingning Zhou, Li Feng, Xiangwei Li, Yongyue Guo, Yuanyuan He, Wanlin He, Xiaoqi Huang, Xiaoqi Huang   +16 more
doaj   +1 more source

Association Between Plasma N-Acylethanolamides and High Hemoglobin Concentration in Southern Peruvian Highlanders

, 2017
High-altitude (HA) hypoxia is a stressful condition endured by organisms through different mechanisms. Failing to adapt to chronic HA exposure leads to a disease called chronic mountain sickness (CMS) characterized by excessive erythrocytosis (hemoglobin
Dulce E. Alarcón-Yaquetto, Lidia Caballero, Gustavo F. Gonzales, Caballero, L, Gonzales Rengifo, Gustavo Francisco, Caballero, Lidia, Alarcon-Yaquetto, DE, Gonzales, GF, Alarcón Yaquetto, Dulce Esperanza   +8 more
core   +1 more source

Blood rheology adjustments in rats after a program of intermittent exposure to hypobaric hypoxia

, 2013
Esteva, Santiago, Pere Panisello, Joan Ramon Torrella, Teresa Pagés, and Ginés Viscor. Blood rheology adjustments in rats after a program of intermittent exposure to hypobaric hypoxia. High Alt. Med. Biol. 10:275-281, 2009. Intermittent hypobaric hypoxia
Esteva i Gras, Santiago, Panisello Tafalla, Pere, Torrella Guio, Joan Ramon, Pagés, Teresa, Viscor Carrasco, Ginés   +4 more
core   +1 more source

Effect of High Altitude on Serum Biochemical Parameters, Immunoglobulins, and Rumen Metabolism of Sanhe Heifers

Fermentation
Rumen metabolism is closely related to feed utilization and the environmental adaptability of cows. However, information on the influence of altitude on ruminal metabolism is limited.
Xinyu Zhang, Zhijun Cao, Hongjian Yang, Yajing Wang, Wei Wang, Shengli Li   +5 more
doaj   +1 more source

Regulation and adaptation of endocrine axes at high altitude [PDF]

American Journal of Physiology-Endocrinology and Metabolism, 2020
As a model of extreme conditions, eight healthy women, part of a 40-member Nepal mountain-climbing expedition, were monitored for dynamic endocrine adaptations. Endocrine measurements were made at frequent intervals over a 6–10-h period at four altitudes: 450 m, 4,800 m (base camp), 6,050 m, and again at 4,800 m (on descent) after an acclimatization ...
Keenan DM, Pichler Hefti J, Veldhuis JD, Von Wolff M   +3 more
openaire   +3 more sources