Results 11 to 20 of about 163,557 (294)

Metabolic adaptation to high altitude

Current Opinion in Endocrine and Metabolic Research, 2020
At high-altitude, hypobaric hypoxia is a significant stress for humans and other animals, challenging oxygen homeostasis and therefore tissue metabolism. Genetic signals of physiological adaptation have been identified in human populations and non-human species with long-term residence at high-altitude.
O'Brien, Katie, Simonson, Tatum, Murray, Andrew   +2 more
core   +4 more sources

Measuring high-altitude adaptation [PDF]

Journal of Applied Physiology, 2017
High altitudes (>8,000 ft or 2,500 m) provide an experiment of nature for measuring adaptation and the physiological processes involved. Studies conducted over the past ~25 years in Andeans, Tibetans, and, less often, Ethiopians show varied but distinct O2transport traits from those of acclimatized newcomers, providing indirect evidence for genetic ...
Lorna G. Moore
openaire   +3 more sources

Adaptation to High Altitude

Defence Science Journal, 1984
Hypoxia is inconsequential for physiologically fit persons below an effective altitude of 2640 metres. At higher altitudes, the adaptation is brought about by four main factors, viz., hyperventilation, increased diffusion of oxygen across alveolar membrane, erythrocythemia and maintenance of body hydration.
Nayar, H. S.
openaire   +3 more sources

De Novo Transcriptomic and Metabolomic Analyses Reveal the Ecological Adaptation of High-Altitude Bombus pyrosoma

Insects, 2020
Bombus pyrosoma is one of the most abundant bumblebee species in China, with a distribution range of very varied geomorphology and vegetation, which makes it an ideal pollinator species for research into high-altitude adaptation.
Yanjie Liu, Huiyue Zhao, Qihua Luo, Yadong Yang, Guangshuo Zhang, Zhiyong Zhou, Muhammad Naeem, Jiandong An   +7 more
doaj   +2 more sources

DNA methylation in adaptation to high-altitude environments and pathogenesis of related diseases

Human Genomics
High-altitude environments, characterized by hypoxia, low temperatures, and intense ultraviolet radiation, pose significant challenges to human physiology and health.
Xingkai Zhang, Yuxi Yang, Qinghai Shi
doaj   +2 more sources

Genomic signatures of high-altitude adaptation and chromosomal polymorphism in geladas [PDF]

, 2022
Primates have adapted to numerous environments and lifestyles, but very few species are native to high elevations. Here, we investigated high-altitude adaptations in the gelada (Theropithecus gelada), a monkey endemic to the Ethiopian Plateau.
Bergey, Christina M, Lemma, Alemayehu, Beehner, Jacinta C, Signore, Anthony V., Beehner, Jacinta C., Rogers, Jeffrey, Lu, Amy, Schneider-Crease, India A, Snyder-Mackler, Noah, Phillips-Conroy, Jane E, Janiak, MC, Chuma, Idrissa S, Phillips-Conroy, Jane E., Storz, Jay F., Chuma, Idrissa S., Burrell, Andrew S., Signore, Anthony V, Haile, Abebaw Azanaw, Storz, Jay F, Melin, Amanda D., Houck, Marlys L, Chiou, Kenneth L., Ayele, Ferehiwot, Wall, Jeffrey D, Janiak, Mareike C., Knauf, Sascha, Jolly, Clifford J, Fashing, Peter J, Burrell, Andrew S, Kebede, Fanuel, Schneider-Crease, India A., Melin, Amanda D, Jolly, Clifford J., McCann, Colleen, Fashing, Peter J., Bergey, Christina M., Bergman, Thore J., Wall, Jeffrey D., Houck, Marlys L., Nguyen, Nga, D'Ippolito, Anthony M, D’Ippolito, Anthony M., Bergman, Thore J, Chiou, Kenneth L, Sen, Sharmi, Abebe, Belayneh   +45 more
core   +1 more source

Adaptation Mechanisms of Yak (Bos grunniens) to High-Altitude Environmental Stress

Animals, 2021
Living at a high altitude involves many environmental challenges. The combined effects of hypoxia and cold stress impose severe physiological challenges on endothermic animals.
Wondossen Ayalew, Min Chu, Chunnian Liang, Xiaoyun Wu, Ping Yan   +4 more
doaj   +1 more source

Alterations of Gut Microbiome in Tibetan Patients With Coronary Heart Disease

Frontiers in Cellular and Infection Microbiology, 2020
Coronary heart disease (CHD) is closely related to gut microbiota, which may be significantly affected by ethnicity and the environment. Knowledge regarding the gut microbiome of Tibetan CHD patients living in the Qinghai–Tibet Plateau is very limited ...
Fengyun Liu, Fengyun Liu, Chao Fan, Chao Fan, Liangzhi Zhang, Yuan Li, Yuan Li, Haiwen Hou, Haiwen Hou, Yan Ma, Yan Ma, Jinhua Fan, Jinhua Fan, Yueqin Tan, Yueqin Tan, Tianyi Wu, Tianyi Wu, Shangang Jia, Yanming Zhang   +18 more
doaj   +1 more source

Renal Physiological Adaptation to High Altitude: A Systematic Review

Frontiers in Physiology, 2020
Background: Under normal physiological conditions, renal tissue oxygen is tightly regulated. At high altitude, a physiological challenge is imposed by the decrease in atmospheric oxygen.
Lisa M. Palubiski, Ken D. O'Halloran, Julie O'Neill   +2 more
doaj   +1 more source

Genomic adaptation of Ethiopian indigenous cattle to high altitude

Frontiers in Genetics, 2022
The mountainous areas of Ethiopia represent one of the most extreme environmental challenges in Africa faced by humans and other inhabitants. Selection for high-altitude adaptation is expected to have imprinted the genomes of livestock living in these ...
Endashaw Terefe, Endashaw Terefe, Endashaw Terefe, Gurja Belay, Jianlin Han, Jianlin Han, Olivier Hanotte, Olivier Hanotte, Olivier Hanotte, Abdulfatai Tijjani, Abdulfatai Tijjani   +10 more
doaj   +1 more source