Results 1 to 10 of about 26,575 (158)

Application of a novel haplotype‐based scan for local adaptation to study high‐altitude adaptation in rhesus macaques

Evolution Letters, 2021
When natural populations split and migrate to different environments, they may experience different selection pressures that can lead to local adaptation.
Zachary A. Szpiech, Taylor E. Novak, Nick P. Bailey, Laurie S. Stevison   +3 more
doaj   +2 more sources

Selection signatures for high‐altitude adaptation in ruminants [PDF]

Animal Genetics, 2020
SummaryHigh‐altitude areas are important socio‐economical habitats with ruminants serving as a major source of food and commodities for humans. Living at high altitude, however, is extremely challenging, predominantly due to the exposure to hypoxic conditions, but also because of cold temperatures and limited feed for livestock.
Juliane Friedrich, P Wiener
exaly   +4 more sources

Epigenomics and human adaptation to high altitude [PDF]

Journal of Applied Physiology, 2017
Over the past decade, major technological and analytical advancements have propelled efforts toward identifying the molecular mechanisms that govern human adaptation to high altitude. Despite remarkable progress with respect to the identification of adaptive genomic signals that are strongly associated with the “hypoxia-tolerant” physiological ...
Colleen G Julian
exaly   +3 more sources

Cardioprotective effects of high-altitude adaptation in cardiac surgical patients: a retrospective cohort study with propensity score matching [PDF]

Frontiers in Cardiovascular Medicine
BackgroundThe cardioprotective effect of remote ischemia preconditioning in clinical studies is inconsistent with experimental results. Adaptation to high-altitude hypoxia has been reported to be cardioprotective in animal experiments.
Li Lei, Mengxue Liu, Die Ma, Xia Lei, Si Zeng, Peng Li, Keli Huang, Juanjuan Lyu, Qian Lei   +8 more
doaj   +2 more sources

Key miRNAs and Genes in the High-Altitude Adaptation of Tibetan Chickens [PDF]

Frontiers in Veterinary Science, 2022
Tibetan chickens living at high altitudes show specific physiological adaptations to the extreme environmental conditions. However, the regulated base of how chickens adapt to high-altitude habitats remains largely unknown. In this study, we sequenced 96
Binlong Chen, Diyan Li, Bo Ran, Pu Zhang, Tao Wang   +4 more
doaj   +2 more sources

High altitude adaptation, common high-altitude disorders and the effects of high altitude on mental health A narrative review

Sports Psychiatry
: Introduction: The human brain is a highly oxygen-dependent organ. Low environmental oxygen availability (e.g., hypobaric hypoxia at altitude) is a major challenge to the brain and numerous endogenous cellular and systemic hypoxia responses therefore ...
Johannes Burtscher, Katharina Hüfner, Martin Kopp, Florian Schipplick, Wolfgang Schobersberger, Hannes Gatterer   +5 more
doaj   +2 more sources

Editorial: Integrative physiological approaches to understand high altitude adaptation [PDF]

Frontiers in Physiology
Esteban Ortiz-Prado, Niroj Kumar Sethy, Jorge Vasconez-Gonzalez, Juan S. Izquierdo-Condoy   +3 more
doaj   +2 more sources

Predictive model for estimating the risk of high-altitude pulmonary edema: a single-centre retrospective outcome-reporting study

BMJ Open, 2023
Objective To develop the first prediction model based on the common clinical symptoms of high-altitude pulmonary edema (HAPE), enabling early identification and an easy-to-execute self-risk prediction tool.Methods A total of 614 patients who consulted ...
Ju Huang, Yangzong Suona, Luobu Gesang, Zhuoga Danzeng, Bai Ci, Quzong Zhaxi   +5 more
doaj   +1 more source

Comparative transcriptomics of high-altitude Vulpes and their low-altitude relatives

Frontiers in Ecology and Evolution, 2022
The harsh environment of Qinghai-Tibet Plateau (QTP) imposes strong selective stresses (e.g., hypoxia, high UV-radiation, and extreme temperature) to the native species, which have driven striking phenotypic and genetic adaptations.
Tianshu Lyu, Tianshu Lyu, Xiufeng Yang, Chao Zhao, Lidong Wang, Shengyang Zhou, Lupeng Shi, Yuehuan Dong, Huashan Dou, Honghai Zhang   +9 more
doaj   +1 more source

Human adaptation to high altitude: a review of convergence between genomic and proteomic signatures

Human Genomics, 2022
Both genomics- and proteomics-based investigations have identified several essential genes, proteins, and pathways that may facilitate human adaptive genotype/phenotype in a population-specific manner.
Vandana Sharma, Rajeev Varshney, Niroj Kumar Sethy   +2 more
doaj   +1 more source