Results 21 to 30 of about 163,557 (294)

Genomic and physiological mechanisms of high-altitude adaptation in Ethiopian highlanders: a comparative perspective [PDF]

Frontiers in Genetics
Changqing Zeng
exaly   +2 more sources

Design and conduct of 'Xtreme Alps' : a double-blind, randomised controlled study of the effects of dietary nitrate supplementation on acclimatisation to high altitude [PDF]

, 2013
The study of healthy human volunteers ascending to high altitude provides a robust model of the complex physiological interplay that emulates human adaptation to hypoxaemia in clinical conditions.
Meale, Paula M., Mythen, Monty, Mythen, Michael G., Cobb, Alexandra, Levett, Denny Z.H., Xtreme Alps Research Group, Grocott, Michael P.W., Gilbert-Kawai, Edward T., Feelisch, Martin, Cumpstey, Andrew, Martin, Daniel S., Fernandez, Bernadette O., Mitchell, Kay, Khosravi, Maryam   +13 more
core   +1 more source

The effect of high-altitude on human skeletal muscle energetics: P-MRS results from the Caudwell Xtreme Everest expedition [PDF]

, 2010
Many disease states are associated with regional or systemic hypoxia. The study of healthy individuals exposed to high-altitude hypoxia offers a way to explore hypoxic adaptation without the confounding effects of disease and therapeutic interventions ...
Grocott Mike P., Edwards, Lindsay M, Holloway, CJ, Mike P Grocott, Grocott, Mike P, Edwards, LM, Neubauer, Stefan, Hugh E Montgomery, Murray Andrew J., Peter A Robbins, Robbins Peter A., Robbins, Peter A., Montgomery, Hugh E., Robbins, Peter A, Grocott, Mike P.W., Tyler Damian J., Earnest, Conrad P., Holloway Cameron J., Damian J Tyler, Murray, Andrew J, Caudwell Xtreme Everest Research Group, Clarke Kieran, Montgomery, Hugh E, Kemp Graham J., Andrew J Murray, Murray, AJ, ?, ?, Neubauer Stefan, Clarke, K, Robbins, Peter, Denny Levett, Holloway, Cameron J, Holloway, Cameron J., Kieran Clarke, Graham J Kemp, Montgomery Hugh E., Murray, Andrew J., Grocott, Mike P., Levett Denny, Grocott, MP, Caudwell Xtreme Everest Res Grp, Lindsay M Edwards, Tyler, Damian, Robbins, PA, Edwards, Lindsay M., Kemp, Graham J, Montgomery, HE, Tyler, Damian J, Levett, D, Kemp, Graham J., Neubauer, S, Tyler, DJ, Kemp, GJ, Levett, Denny, Clarke, Kieran, Cameron J Holloway, Tyler, Damian J., Stefan Neubauer, Edwards Lindsay M.   +58 more
core   +1 more source

Wide distribution and altitude correlation of an archaic high-altitude-adaptive EPAS1 haplotype in the Himalayas. [PDF]

, 2016
High-altitude adaptation in Tibetans is influenced by introgression of a 32.7-kb haplotype from the Denisovans, an extinct branch of archaic humans, lying within the endothelial PAS domain protein 1 (EPAS1), and has also been reported in Sherpa.
S. Hackinger (7627076), T. Kraaijenbrink (7627079), Asan (7545038), G. van Driem (7627085), Mark A. Jobling (7579496), Y. Xue (2531134), P. de Knijff (7627088), Q. Ayub (7627091), M. Mezzavilla (7627082), C. Tyler-Smith (7607519)   +9 more
core   +2 more sources

Cerebral Autoregulation in Subjects Adapted and Not Adapted to High Altitude [PDF]

Stroke, 2000
Background and Purpose—Impaired cerebral autoregulation (CA) from high-altitude hypoxia may cause high-altitude cerebral edema in newcomers to a higher altitude. Furthermore, it is assumed that high-altitude natives have preserved CA. However, cerebral autoregulation has not been studied at altitude.Methods—We studied CA in 10 subjects at sea level and
G F, Jansen, A, Krins, B, Basnyat, A, Bosch, J A, Odoom   +4 more
openaire   +2 more sources

The overlooked significance of plasma volume for successful adaptation to high altitude in Sherpa and Andean natives [PDF]

, 2019
In contrast to Andean natives, high altitude Tibetans present with a lower hemoglobin concentration that correlates with reproductive success and exercise capacity.
Dawkins, Tony G., Levine, Benjamin D., Shave, Rob, Gasho, Christopher, Villafuerte, Francisco C., Ainslie, Philip N., Dawkins, Tony, Drane, Aimee, Stembridge, Mike, Williams, Alexandra M., Drane, Aimee L.   +10 more
core   +1 more source

High-altitude adaptation and incipient speciation in geladas: [Preprint] [PDF]

, 2021
Survival at high altitude requires adapting to extreme conditions such as environmental hypoxia. To understand high-altitude adaptations in a primate, we assembled the genome of the gelada (Theropithecus gelada), an endemic Ethiopian monkey, and ...
Lemma, Alemayehu, Signore, Anthony V., Beehner, Jacinta C., Rogers, Jeffrey, Lu, Amy, Snyder-Mackler, Noah, Phillips-Conroy, Jane E., Storz, Jay F., Chuma, Idrissa S., Burrell, Andrew S., Haile, Abebaw Azanaw, Melin, Amanda D., Chiou, Kenneth L., Ayele, Ferehiwot, Janiak, Mareike C., Knauf, Sascha, Kebede, Fanuel, Jolly, Clifford J., McCann, Colleen, Fashing, Peter J., Bergey, Christina M., Bergman, Thore J., Wall, Jeffrey D., Houck, Marlys L., Nguyen, Nga, D'Ippolito, Anthony M., Sen, Sharmi, Abebe, Belayneh, Schneider-Crease, India   +28 more
core   +1 more source

Comparative analysis of the microRNA transcriptome between yak and cattle provides insight into high-altitude adaptation [PDF]

PeerJ, 2017
Extensive and in-depth investigations of high-altitude adaptation have been carried out at the level of morphology, anatomy, physiology and genomics, but few investigations focused on the roles of microRNA (miRNA) in high-altitude adaptation. We examined
Jiuqiang Guan, Keren Long, Jideng Ma, Jinwei Zhang, Dafang He, Long Jin, Qianzi Tang, Anan Jiang, Xun Wang, Yaodong Hu, Shilin Tian, Zhi Jiang, Mingzhou Li, Xiaolin Luo   +13 more
doaj   +2 more sources

Structured pancreas changes in deadaptation process to high altitude

Бюллетень сибирской медицины, 2009
Study of the pancreas of the rats at different periods deadaptation to valley, after 60 day adaptations to mountain has revealled significant change, which at the first periods of the study (7, 15 day) were concluded in edema stroma, inflammatory round ...
T. N. Slynko, M. Ya. Velikorodova, N. N. Zarechnova   +2 more
doaj   +1 more source

Genomic scan reveals loci under altitude adaptation in Tibetan and Dahe pigs. [PDF]

PLoS ONE, 2014
High altitude environments are of particular interest in the studies of local adaptation as well as their implications in physiology and clinical medicine in human.
Kunzhe Dong, Na Yao, Yabin Pu, Xiaohong He, Qianjun Zhao, Yizhao Luan, Weijun Guan, Shaoqi Rao, Yuehui Ma   +8 more
doaj   +1 more source