Results 101 to 110 of about 34,892 (283)

Cellular Signalling Networks in High Altitude Pulmonary Hypertension: From Canonical Pathways to Emerging Targets

Cell Proliferation, EarlyView.
This review elucidates the intricate cellular signalling networks involved in high‐altitude pulmonary hypertension (HAPH), integrating canonical pathways like HIF, MAPK and BMP with emerging targets such as Wnt/β‐catenin, Notch, Hippo‐YAP and IL‐6. It highlights potential therapeutic strategies targeting these pathways to mitigate vascular remodelling ...
Sheng Ding, Ju Chen, Zhaoyang Li, Yang Yu, Weijie Wang, Yan Liao, Jin Yang, Dianxiang Lu, Yujiang Fan   +8 more
wiley   +1 more source

Post-exercise parasympathetic reactivation and sensibility to hypoxia [PDF]

, 2012
Introduction Exposure to hypoxia leads to several reactions of the organism, which try to compensate the reduced oxygen level in the blood. Acute response is characterized by an increase in pulmonary ventilation (Hypoxia Ventilatory Response, HVR) and in
Leuzinger, M.
core  

Impact of Environmental Exposure on Infant Sleep : The Exposome Approach

Journal of Sleep Research, EarlyView.
This review explores how exposure to environmental pollutants during the first 1000 days of life may affect infant sleep. Evidence suggests potential links between chemical exposures and sleep disturbances, underscoring the need for more research on early‐life vulnerability and the impact of pollutants in air, diet, and breast milk.
Zeina Halbouty, Debora Tuka, Erwan Stephan‐Blanchard, Veronique Bach, Pierre Tourneux, Elodie Haraux, Karen Chardon   +6 more
wiley   +1 more source

Nonlinear effects of altitude on child growth in Peru : a multilevel analysis [PDF]

Growth at high altitude has been the object of many investigations after experimental studies on animals showed that hypoxia at high altitude slows growth. Many studies have also looked at the Andean populations and found different results. Even though a
Gragnolati, Michele, Marini, Alessandra
core  

Effects of exposure to altitude on neuropsychology aspects: a literature review [PDF]

, 2010
OBJECTIVE: Discuss the effects of altitude exposure on neuropsychological functions. METHOD: We have conducted a literature review using as source indexed articles at Pubmed in the period from 1921 to 2008, using the following key words: cognition and ...
Antunes, Hanna Karen Moreira, Lemos, Valdir de Aquino, Mello, Marco Tulio de, Prado, Juliana Martuscelli da Silva, Santos, Ronaldo Vagner Thomatieli dos, Tufik, Sergio   +5 more
core   +1 more source

Appreciating the Evidence

Philosophical Issues, EarlyView.
ABSTRACT Having evidence does not in itself make a doxastic attitude justified even if the evidence supports the attitude in question. Plausibly, one must also appreciate the support one's evidence provides for the doxastic attitude. Although such appreciation seems central to the picture of justification offered by Evidentialism, its nature has been ...
Kevin McCain
wiley   +1 more source

The Evolution of Cholesterol-Rich Membrane in Oxygen Adaption: The Respiratory System as a Model. [PDF]

, 2019
The increase in atmospheric oxygen levels imposed significant environmental pressure on primitive organisms concerning intracellular oxygen concentration management.
Patel, Hemal H, Zuniga-Hertz, Juan Pablo
core   +1 more source

Sex differences in loop gain measured via superimposed end‐expiratory breath holds and inspired steady‐state hypoxia

Experimental Physiology, EarlyView.
Abstract Acute low oxygen exposure (hypoxia) elicits a hypoxic ventilatory response (HVR), which increases ventilation and mitigates hypoxaemia. During sustained exposure to hypoxia, ventilatory acclimatization increases peripheral chemoreflex (HVR) sensitivity or chemoreflex loop gain (LG).
Benjamin W. L. MacKenzie, Nicole A. Johnson, Nicholas D. J. Strzalkowski, Trevor A. Day   +3 more
wiley   +1 more source

Modulation of cerebral blood flow and cognition by hyperthermia and hypoxia: An electroencephalographic event‐related potentials perspective

Experimental Physiology, EarlyView.
Abstract Cerebral blood flow (CBF) is essential for sustaining neuronal metabolism and cognitive performance; however, the precise relationship between perfusion and cognition remains unclear. Although ageing and disease are associated with progressive declines in CBF and cognitive impairment, the acute effects of altered CBF under environmental ...
Hiroki Nakata, Shigehiko Ogoh, Manabu Shibasaki   +2 more
wiley   +1 more source

Human adaptation to high‐altitude: A contemporary comparison of the oxygen cascade in Andean, Tibetan and Ethiopian highlanders

Experimental Physiology, EarlyView.
Abstract Human populations native to high altitude have evolved distinct physiological adaptations to chronic hypoxia. This adaptation is evident in the O2 transport cascade. In this review, with brief inclusion of the related genetic adaptations, we compare the O2 cascade across three well‐characterized high‐altitude populations: Andeans (Aymara and ...
Ayechew A. Getu, Melissa Ilardo, Joshua C. Tremblay, Jay M. J. R. Carr, Vitalie Faoro, Philip N. Ainslie   +5 more
wiley   +1 more source