Results 41 to 50 of about 34,892 (283)

Introgressive Hybridization and Hypoxia Adaptation in High-Altitude Vertebrates [PDF]

Frontiers in Genetics, 2021
In natural populations of animals, a growing body of evidence suggests that introgressive hybridization may often serve as an important source of adaptive genetic variation. Population genomic studies of high-altitude vertebrates have provided strong evidence of positive selection on introgressed allelic variants, typically involving a long-term ...
Jay F. Storz, Anthony V. Signore
openaire   +3 more sources

Metabolomic analysis of human plasma sample after exposed to high altitude and return to sea level.

PLoS ONE, 2023
When ascending to high altitude, it is a rigorous challenge to people who living in the low altitude area to acclimatize to hypoxic environment. Hypoxia exposure can cause dramatic disturbances of metabolism.
Jiayue Gao, Ming Zhao, Xiang Cheng, Xiangpei Yue, Fangbin Hao, Hui Wang, Lian Duan, Cong Han, Lingling Zhu   +8 more
doaj   +2 more sources

Implications of moderate altitude training for sea level endurance in elite distance runners [PDF]

, 1998
Elite distance runners participated in one of two studies designed to investigate the e ects of mod- erate altitude training (inspiratory partial pressure of oxygen »115±125 mmHg) on submaximal, maximal and supramaximal exercise performance following
Bailey, DM, Castell, L, Davies, B, Gandy, G, Newsholme, E, Romer, L   +5 more
core   +1 more source

Orexin A protects against cerebral ischemia-reperfusion injury by enhancing reperfusion in ischemic cortex via HIF-1α-ET-1/eNOS pathway

Brain Research Bulletin
The purpose of this study was to investigate the protective effect and underlying mechanism of orexin A on cerebral ischemia-reperfusion injury, specifically through vasodilation mediated by the hypoxia inducible factor-1α (HIF-1α)-Endothelin-1(ET-1 ...
Minxia Zhu, Xiaofeng Li, Jing Guo, Zhaojun Zhang, Xu Guo, Zhuoqi Li, Junwei Lin, Pengfei Li, Zixuan Jiang, Yifan Zhu   +9 more
doaj   +1 more source

Hot and hypoxic environments inhibit simulated soccer performance and exacerbate performance decrements when combined. [PDF]

, 2016
The effects of heat and/or hypoxia have been well-documented in match-play data. However, large match-to-match variation for key physical performance measures makes environmental inferences difficult to ascertain from soccer match-play.
Abt, Aldous, Amann, Armatas, Aughey, Balsom, Bartsch, Billaut, Billaut, Borg, Buchheit, Buono, Calbet, Castle, Cheuvront, Cheuvront, Coppel, Coull, Dellal, Dill, Drust, Duffield, Ekblom, Faude, Flouris, Garvican, González-Alonso, Goodall, Gregson, Hillman, Hommel, Lakomy, Levine, Masschelein, Mazzeo, Mohr, Mohr, Mohr, Morales-Alamo, Nassis, Nassis, Nybo, Nybo, Oliver, Périard, Racinais, Racinais, Racinais, Racinais, Ramanathan, Roelands, Sawka, Sawka, Stembridge, Stembridge, Taylor, Taylor, Taylor, Taylor, Thompson, Tonnessen, Vandenbogaerde, West, Wylie, Young, Özgünen   +65 more
core   +8 more sources

Salidroside inhibited the proliferation of gastric cancer cells through up-regulating tumor suppressor miR-1343-3p and down-regulating MAP3K6/MMP24 signal molecules

Cancer Biology & Therapy
Salidroside inhibited the proliferation of cancer cell. Nevertheless, the mechanism has not been completely clarified. The purpose of the study is to explore the mechanisms of salidroside against gastric cancer. To analyze the changes of microRNA (miRNA)
Xiaoping Wang, Zhendong Zhang, Xiaolan Cao   +2 more
doaj   +1 more source

Effects of Normobaric Hypoxia on Oculomotor Dynamics of Aviator Students during a Simulated Flight Task [PDF]

, 2020
Hypoxia occurs when the body\u27s tissues are unable to obtain adequate oxygen supply and is the primary environmental factor present when pilots are exposed to increasing altitude levels.
Blackley, Anna, de Moors, Moroni, Deshner, Austin, Ehrlich, Kaela, Engberg, Josh, Hornsby, Jared, Hu, Theodore, Jankovic, Maja, McCarty, Abby, Morrison, Mitchell, Rider, Carl Wesley, Walsh, Brian   +11 more
core   +1 more source

Altered Oxygen Utilisation in Rat Left Ventricle and Soleus after 14 Days, but Not 2 Days, of Environmental Hypoxia. [PDF]

, 2015
The effects of environmental hypoxia on cardiac and skeletal muscle metabolism are dependent on the duration and severity of hypoxic exposure, though factors which dictate the nature of the metabolic response to hypoxia are poorly understood.
Burgess, Sarah L., Horscroft, James A., Hu, Yaqi, Murray, Andrew J.   +3 more
core   +5 more sources

Renqing Changjue alleviates sepsis-induced acute lung injury by regulating renin-angiotensin system and inhibiting inflammatory response

Immunobiology
Sepsis, with high morbidity and mortality, represents a systemic inflammatory response syndrome. A common consequence of sepsis is acute lung injury (ALI).
Minxia Zhu, Yaqi Lei, Zhaojun Zhang, Xu Guo, Jing Guo, Ruipeng Wu, Xiaofeng Li, Shibo Tian, Yuanhao Zhao   +8 more
doaj   +1 more source

IL-4 polymorphisms (rs2227284, rs2243267, and rs2243270) are associated with reduced risk of rheumatoid arthritis

Autoimmunity
Background Rheumatoid arthritis (RA) is a chronic autoimmune disease, and understanding its genetic and molecular basis is crucial for early diagnosis, treatment, and prevention.Objective This study aims to explore the association between IL-4 ...
Xiaoli Liu, Huqiang Mai, Liang Wang, Hengxun Zhang, Xuemei Li, Xuguang Li, Li Wang   +6 more
doaj   +1 more source