Results 61 to 70 of about 620,339 (314)

Dose-dependent effects of dietary fat on development of obesity in relation to intestinal differential gene expression in C57BL/6J mice

, 2011
Excessive intake of dietary fat is known to be a contributing factor in the development of obesity. In this study, we determined the dose-dependent effects of dietary fat on the development of this metabolic condition with a focus on changes in gene ...
Boekschoten, Mark V., Bachmair, Eva-Maria, de Groot, Philip, Eva-Maria Bachmair, Isabel Rubio-Aliaga, Rubio-Aliaga Isabel, de Wit Nicole J. W., de Wit, Nicole J. W., Rubio-Aliaga, I., Nicole J. W. de Wit, Philip J. de Groot, Machmair, E.M., Boekschoten Mark V., Hooiveld, Guido, Wit, N.J.W., de, Philip J de Groot, de Groot Philip J., Boekschoten, M.V., Muller, M.R., Daniel Hannelore, Hooiveld, Guido J. E. J., Rubio-Aliaga, Isabel, Müller, Michael, Nicole J W de Wit, Guido J E J Hooiveld, Hannelore Daniel, Müller Michael, Daniel, H., Mark V Boekschoten, Michael Müller, Hooiveld Guido J. E. J., de Groot, Philip J., Guido J. E. J. Hooiveld, Bachmair Eva-Maria, Boekschoten, Mark, Daniel, Hannelore, Groot, P.J., de, de Wit, Nicole, Mark V. Boekschoten, Hannelore, Daniel, Hooiveld, G.J.E.J.   +40 more
core   +1 more source

Coffee pulp, a by-product of coffee production, modulates gut microbiota and improves metabolic syndrome in high-carbohydrate, high-fat diet-fed rats [PDF]

, 2021
Waste from food production can be re‐purposed as raw material for usable products to decrease industrial waste. Coffee pulp is 29% of the dry weight of coffee cherries and contains caf‐feine, chlorogenic acid, trigonelline, diterpenes and fibre.
Torsten Thomas, Lindsay Brown, Thomas, Torsten, Bhandarkar, Nikhil S., Bhandarkar, Nikhil S, Peter Mouatt, Majzoub, Marwan E, Panchal, Sunil K, Panchal, Sunil K. (R20071), Nikhil S. Bhandarkar, Sunil K. Panchal, Majzoub, Marwan E., Mouatt, Peter, Marwan E. Majzoub, Panchal, Sunil K., Brown, Lindsay   +15 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Impact of maternal high‐fat diet on offspring gut microbiota during short‐term high‐fat diet exposure in mice

Physiological Reports
Alterations in the gut microbiome have been linked to obesity, with maternal high‐fat diet (HF) playing a role in shaping offspring microbiome composition.
Henry A. Paz, Lasya Buddha, Ying Zhong, James D. Sikes, Umesh D. Wankhade   +4 more
doaj   +1 more source

The role of the small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice

, 2008
Background Obesity and insulin resistance are two major risk factors underlying the metabolic syndrome. The development of these metabolic disorders is frequently studied, but mainly in liver, skeletal muscle, and adipose tissue.
Mechteld M Grootte Bromhaar, Jansen, Jenny, de Groot Philip J, de Groot, P.J., Hooiveld Guido JEJ, Jansen Jenny, Vermeulen, J.J., Nicole JW de Wit, Jansen, J., Müller, M.R., Bosch-Vermeulen, Hanneke, van der Meer, Roelof, de Wit, Nicole J. W., Meer, R., van der, Bromhaar Mechteld, Wit, N.J.W., de, Philip J de Groot, Bosch-Vermeulen Hanneke, Hooiveld, Guido J. E. J., Müller Michael, Müller, Michael, Grootte Bromhaar, M.M., Michael Müller, de Groot, Philip J., Hanneke Bosch-Vermeulen, de Wit Nicole JW, Roelof van der Meer, de Wit, N.J.W., Bromhaar, Mechteld M. Grootte, van der Meer, R., Jenny Jansen, Groot, P.J., de, Guido JEJ Hooiveld, Hooiveld, G.J.E.J., van der Meer Roelof   +34 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, Volume 20, Issue 6, Page 1513-1534, June 2026.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Effects of Persian leek (Allium ampeloprasum) on hepatic lipids and the expression of proinflammatory gene in hamsters fed a high-fat/ high-cholesterol diet [PDF]

Avicenna Journal of Phytomedicine, 2016
Objective: Persian leek is one of the most widely used herbal foods among Iranians. In this study, effects of oral administration of Persian leek on plasma and liver lipids were examined in hamster.
Vahideh Fatoorechi, Marjan Rismanchi, Javad Nasrollahzadeh   +2 more
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Chlorogenic acid attenuates high-carbohydrate, high-fat diet-induced cardiovascular, liver, and metabolic changes in rats

, 2019
Chlorogenic acid as a constituent of coffee is consumed regularly in the human diet. Chlorogenic acid intake has been associated with decreased risk of cardiovascular disease and type 2 diabetes.
Bhandarkar, Nikhil S., Panchal, Sunil K., Brown, Lindsay, Panchal, Sunil K. (R20071)   +3 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source