Results 171 to 180 of about 10,771 (216)

High-Grade Prostatic Intraepithelial Neoplasia in Dogs

European Urology, 1999
The dog is the only nonhuman species in which high-grade intraepithelial neoplasia (HGPIN) and invasive carcinoma spontaneously occur. Our work was the first to describe HGPIN in the dog prostate. Canine HGPIN bears remarkable morphologic similarity to its human counterpart.
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High-grade prostatic intraepithelial neoplasia: State-of-the-art

Arkhiv patologii, 2015
According to current views, high-grade prostatic intraepithelial neoplasia is the most likely precursor of prostate adenocarcinoma. This review gives the latest data of genetic, proteomic, and morphological analyses of this neoplasia and touches upon the probems that might arise when searching for new markers for differential diagnosis and prognosis ...
D O, Allina, Yu Yu, Andreeva, L E, Zavalishina, T V, Kekeeva, G A, Frank   +4 more
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Immunoreactive p53 Protein in High-Grade Prostatic Intraepithelial Neoplasia

Pathology - Research and Practice, 1995
p53 protein accumulation in the nuclei of prostatic carcinoma cells, as detected by immunohistochemistry, has been associated with increased cell proliferation rate, increased histologic grade and stage, androgen independence and decreased patient survival.
P A, Humphrey, P E, Swanson
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CDK19 as a diagnostic marker for high-grade prostatic intraepithelial neoplasia

Human Pathology, 2021
High-grade prostatic intraepithelial neoplasia (HGPIN) is a facultative precursor lesion of prostate cancer (PCa). Multifocal HGPIN in needle biopsies in the absence of PCa indicates a higher risk of cancer detection in subsequent biopsies. Therefore, a reliable diagnosis of HGPIN is of high clinical relevance guiding the management of patients with ...
Anne, Offermann, Vincent, Joerg, Marie C, Hupe, Finn, Becker, Marten, Müller, Johannes, Brägelmann, Jutta, Kirfel, Axel S, Merseburger, Verena, Sailer, Lars, Tharun, Sven, Perner   +10 more
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Ductal Spread Versus High-Grade Prostatic Intraepithelial Neoplasia

International Journal of Surgical Pathology, 2016
Ductal spread (DS) of acinar adenocarcinoma of the prostate can lead to an incomplete replacement of the benign epithelium by cancer cells, resulting in a lesion that can be indistinguishable from high-grade prostatic intraepithelial neoplasia (HGPIN).
Andres M, Acosta, Asma, Sharif, John V, Groth, Andre, Kajdacsy-Balla   +3 more
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High-Grade Prostatic Intraepithelial Neoplasia

2017
High-grade prostatic intraepithelial neoplasia is the precursor lesion for prostatic acinar adenocarcinoma. While common spatial, epidemiological, histological and immunophenotypical features exist between high-grade prostatic intraepithelial neoplasia and adnocarcinoma, they also share different cytogenetic, mutational and molecular abnormalities ...
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High grade prostatic intraepithelial neoplasia is a disease

Current Urology Reports, 2001
High grade prostatic intraepithelial neoplasia (PIN) is now widely accepted as the main premalignant lesion that has the potential to progress to prostate adenocarcinoma. High grade PIN is a standard diagnosis that must be included as part of the reported pathologic evaluation of prostate biopsies.
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High-grade prostatic intraepithelial neoplasia and prostate cancer risk reduction

World Journal of Urology, 2003
High-grade prostatic intraepithelial neoplasia (PIN) is the earliest accepted stage in carcinogenesis, possessing most of the phenotypic and biochemical changes in cancer without invasion of the basal membrane of the acini. The support for high-grade PIN as the main premalignant lesion of prostate cancer is based on several lines of evidence derived ...
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High‐grade prostate intraepithelial neoplasia shares cytogenetic alterations with invasive prostate cancer

The Prostate, 2001
AbstractBACKGROUNDHigh‐grade prostate intraepithelial neoplasia (PIN) is the most likely precursor of prostate adenocarcinoma. However, the relationship between this lesion and prostate cancer has not yet been established. The detection of cytogenetic changes in the lesions prior to prostate adenocarcinoma would be useful in demonstrating such a ...
A, Alcaraz, M A, Barranco, J M, Corral, M J, Ribal, A, Carrió, C, Mallofré, J, Llopis, A, Cetina, R, Alvarez-Vijande   +8 more
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Radical prostatectomy for High Grade Prostatic Intra-epithelial Neoplasia

International Urology and Nephrology, 2001
High Grade Prostatic Intraepithelial Neoplasia (HGPIN) has been recognized as the most likely precursor of invasive carcinoma of the prostate. Close surveillance and follow-up are indicated if subsequent procedures fail to identify carcinoma. There is still considerable controversy about the natural history of high grade PIN and most authors agree that
R, Woderich, J, McLoughlin, S, Deen
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