Results 231 to 240 of about 755,147 (291)

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Metabolomic analysis of fatal hypothermia using ultra-high-performance liquid chromatography‒mass spectrometry. [PDF]

Front Mol Biosci
Li JH, Liu JL, Song JW, Deng WL, Cao XZ, Wu ZW, Chen DH, Wang H, Yu S, Wang Q.   +9 more
europepmc   +1 more source

Divergent Regulatory Effects of Jasmonic Acid on Tomato Lycopene Biosynthesis Under Light and Dark Conditions

Advanced Science, EarlyView.
This study reveals the mechanism by which jasmonic acid (JA) regulates lycopene synthesis under light and dark conditions. In light, JA activates SlMYC2, which suppresses SlPIF1a and promotes SlPSY1 expression. In darkness, JA induces the acetyltransferase SlNATA1, which acetylates the dark‐accumulated SlPIF1a, thereby repressing SlPSY1 expression ...
Jiayi Xu, Lingfeng He, Jialong Zhang, Hao Cui, Hongxin Li, Haijun Zhang, Jiaojiao Zhang, Lun Liu, Kunpeng Xu, Yang‐Dong Guo, Na Zhang   +10 more
wiley   +1 more source

Enantioseparation of Mirabegron Using Cyclodextrin-based Chiral Columns: High-performance Liquid Chromatography and Molecular Modeling Study. [PDF]

J Sep Sci
Mhammad A, Dombi G, Dobó M, Szabó ZI, Fiser B, Tóth G.   +5 more
europepmc   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Network pharmacology combined with ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry method to explore the mechanism of Shizhi Fang in treating uric acid nephropathy mice. [PDF]

J Tradit Chin Med
Feng Y, Xuming Z, Zhiyuan WU, Jiandong G.   +3 more
europepmc   +1 more source

Climate Change Threatens Micronutrient Density of European Winter Wheat

Advanced Science, EarlyView.
Micronutrients are vital for human health. Wheat is a major staple crop and a significant source of minerals and B‐vitamins. The impact of climate change on their content remains largely unknown. We evaluated micronutrient levels in European winter wheat grown under historical and projected climate conditions. Our findings indicate that future climates
Da Cao, Jennifer Michel, Eline Lorer, Markus Weinmann, Jacques Le Gouis, Claire Léon, Sibille Perrochon, David Alvarez, Vincent Leemans, Iñaki Balanzategui Guijarro, Jordi Moya Laraño, Sara Sánchez Moreno, Symanczik Sarah, Waibel Matthias, Hervé Vanderschuren, Cécile Thonar, Pierre Delaplace, Dominique Van Der Straeten   +17 more
wiley   +1 more source

Optimization and Validation of a High-Performance Liquid Chromatography (HPLC-UV) Method for Quantification of α-Lipoic Acid in Cyclodextrins Complex for Ocular Delivery. [PDF]

Biomed Chromatogr
Ta PL, Bernat-Just L, Alambiaga-Caravaca AM, Rodilla V, López-Castellano A, Bosch-Morell F.   +5 more
europepmc   +1 more source

Validation of a reversed-phase high-performance liquid chromatography method for quantification of allantoin, creatinine, and uric acid in individual spot cow urine samples. [PDF]

JDS Commun
Visentin E, Sousa I, Magro S, Sabbadin S, Niero G, De Marchi M.   +5 more
europepmc   +1 more source

Successful Management of Infective Endocarditis Utilizing Rapid High-performance Liquid Chromatography-based Therapeutic Drug Monitoring: Balancing Linezolid Efficacy and Thrombocytopenia Risk. [PDF]

Intern Med
Kobayashi S, Numata R, Machino-Ohtsuka T, Suzuki H, Ishizu T.   +4 more
europepmc   +1 more source