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Mass microscopy: high-resolution imaging mass spectrometry

Journal of Electron Microscopy, 2010
Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a technique that localizes the spatial distribution of molecules and identifies structures by their molecular mass signatures. Recently, the resolution of MALDI-IMS has been up to microscopic level. MALDI-IMS does not need either separation or purification procedures
Mitsutoshi, Setou, Nobuya, Kurabe
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High resolution field desorption mass spectrometry

Analytica Chimica Acta, 1976
Abstract Sulphate esters and sulphate salts of biochemicals and pharmacologically active compounds have been investigated by field desorption mass spectrometry. The underivatized substances gave high cation and cluster ion intensities. Low, but structurally significant, fragmentation was observed.
H.-R. Schulten, W.D. Lehmann
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High resolution mass spectrometry. Bufadienolides—II.

Organic Mass Spectrometry, 1972
AbstractComplete low resolution mass spectra and high resolution data for selected important peaks are presented and discussed for a series of naturally occurring 14β, 15β‐epoxybufadienolides (toad poisons) and their derivatives. The compounds examined were resibufogenin, marinobufagin, cinobufagin, desacetylcinobufagin, cinobufotalin ...
Peter Brown   +2 more
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High-resolution laser mass spectrometry

International Journal of Mass Spectrometry and Ion Processes, 1984
Abstract Multi-photon absorption within the small focus of an intense pulsed laser beam leads to an efficient ionization of the absorbing molecules. The point-like ionization region and the peculiar multi-photon excitation mechanism make for an ideal ion source for a mass spectrometer.
H.J. Neusser   +3 more
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Electrospray Ionization High-Resolution Ion Mobility Spectrometry−Mass Spectrometry

Analytical Chemistry, 1998
A hybrid atmospheric pressure ion mobility spectrometer is described which exhibits resolving power approaching the diffusion limit for singly and multiply charged ions (over 200 for the most favorable case). Using an electrospray ionization source and a downstream quadrupole mass spectrometer with electron multiplier as detector, this ESI-IMS-MS ...
C, Wu   +3 more
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High-Resolution Liquid Chromatography–Mass Spectrometry for Lipidomics

2023
Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) is a powerful tool for identification and classification of lipids. Ultra-high performance liquid chromatography (UHPLC) allows for robust separations of complex mixtures, while high-resolution mass spectrometry (HRMS) identifies compounds with efficiency and accuracy (Zullig T and ...
Faith Christine, Harvey   +2 more
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Choosing between high-resolution mass spectrometry and mass spectrometry/mass spectrometry environmental applications

Environmental Science & Technology, 1990
Selectivity in environmental analyses requires the use of fractionation techniques and HRMS or MS/MS to eliminate specific and nonspecific interferences. In the analysis of TCDDs and TCDFs, HRMS is the method of choice when specific interferences arising from compounds with molecular or fragment ions can be separated from TCDD and TCDF ions at a ...
M. Judith Charles, Yves Tondeur
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HIGH-RESOLUTION MASS SPECTROMETRY

1971
Mass Spectrometry is unique in the type and amount of information that it can often supply on submicrogram samples. Recent advances include improved understanding of the basic factors affecting ion reaction rates, and application of these in metastable and collision-induced decompositions.
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High resolution mass spectrometry of trimethylamine

Organic Mass Spectrometry, 1970
AbstractHigh resolution shows that the four principal fragment peaks of trimethylamine are singlets. Close studies of the metastable transitions in the spectrum have established the origin of almost all fragment peaks.
Georg Hvistendahl, Kjell Undheim
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Yeast Expression Proteomics by High-Resolution Mass Spectrometry

2010
Comprehensive analysis of yeast as a model system requires to reliably determine its composition. Systematic approaches to globally determine the abundance of RNAs have existed for more than a decade and measurements of mRNAs are widely used as proxies for detecting changes in protein abundance.
Walther, Tobias C   +2 more
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