Results 91 to 100 of about 1,467,276 (295)

The magnetic field of IRAS 16293-2422 as traced by shock-induced H2O masers

open access: yes, 2012
Shock-induced H2O masers are important magnetic field tracers at very high density gas. Water masers are found in both high- and low-mass star-forming regions, acting as a powerful tool to compare magnetic field morphologies in both mass regimes. In this
Bisschop   +44 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Radar High-Resolution Range Profile Rejection Based on Deep Multi-Modal Support Vector Data Description

open access: yesRemote Sensing
Radar Automatic Target Recognition (RATR) based on high-resolution range profile (HRRP) has received intensive attention in recent years. In practice, RATR usually needs not only to recognize in-library samples but also to reject out-of-library samples ...
Yue Dong   +6 more
doaj   +1 more source

Method for compensating bandwidth error of synthetic wideband radar signal

open access: yesThe Journal of Engineering, 2019
The synthetic wideband signal has the advantages of high range and velocity resolution. It has a wide range of applications in target detection and recognition.
Xiaoxin Han   +3 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Accretion Signatures from Massive Young Stellar Objects

open access: yes, 2004
High resolution (lambda / Delta-lambda = 50,000) K-band spectra of massive, embedded, young stellar objects are presented. The present sample consists of four massive young stars located in nascent clusters powering Galactic giant H II regions.
A. Damineli   +9 more
core   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Natural Coronagraphic Observations of the Eclipsing T Tauri System KH 15D: Evidence for Accretion and Bipolar Outflow in a WTTS

open access: yes, 2003
We present high resolution (R $\sim$ 44,000) UVES spectra of the eclipsing pre-main sequence star KH 15D covering the wavelength range 4780 to 6810 {\AA} obtained at three phases: out of eclipse, near minimum light and during egress. The system evidently
Bailer-Jones, Coryn A. L.   +4 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

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