Results 61 to 70 of about 1,467,276 (295)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Generalized Zero-Shot Space Target Recognition Based on Global-Local Visual Feature Embedding Network

Remote Sensing, 2023
Existing deep learning-based space target recognition methods rely on abundantly labeled samples and are not capable of recognizing samples from unseen classes without training.
Yuanpeng Zhang, Jingye Guan, Haobo Wang, Kaiming Li, Ying Luo, Qun Zhang   +5 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Airborne Lidar measurements of the atmospheric pressure profile with tunable Alexandrite lasers [PDF]

, 1986
The first remote measurements of the atmospheric pressure profile made from an airborne platform are described. The measurements utilize a differential absorption lidar and tunable solid state Alexandrite lasers. The pressure measurement technique uses a
Dombrowski, M., Korb, C. L., Milrod, J., Schwemmer, G. K., Walden, H.   +4 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Cuspy No More: How Outflows Affect the Central Dark Matter and Baryon Distribution in Lambda CDM Galaxies

, 2012
We examine the evolution of the inner dark matter (DM) and baryonic density profile of a new sample of simulated field galaxies using fully cosmological, Lambda CDM, high resolution SPH + N-Body simulations.
A. M. Brooks, A. Pontzen, A. Zolotov, Abdo, Adams, Agertz, Ahn, Avila Reese, Barnes, Bell, Belokurov, Benson, Bigiel, Bode, Bower, Boylan-Kolchin, Brook, Brooks, Brooks, Bruzual, Bullock, C. Christensen, Ceverino, Chemin, Choi, Christensen, Colín, Conroy, Croft, Dalal, Dalcanton, Dalcanton, Davé, de Blok, de Blok, de Souza, Dekel, Dekel, Dekel, Del Popolo, Donato, Eke, El-Zant, Elmegreen, Elson, Evans, F. Governato, Fall, Feldmann, Flores, Font, Geha, Geha, Gentile, Gnedin, Gnedin, Goerdt, Goerdt, Governato, Governato, Governato, Guedes, Haardt, Hopkins, J. Wadsley, Katz, Kazantzidis, Kennicutt, Kereš, Kirby, Knebe, Knollmann, Koda, Koposov, Krumholz, Kuzio de Naray, Lackner, Li, Loeb, Lovell, Macciò, Macciò, Macciò, Martin, Martinez, Mashchenko, Mashchenko, Mayer, Mayer, McGaugh, McQuinn, Mo, Moore, Moore, Moster, Navarro, Navarro, Navarro, Oh, Oh, Oh, Oppenheimer, Parry, Peñarrubia, Pontzen, Pontzen, Pontzen, Primack, Quinn, Rashkov, Read, Reed, Riess, Romano-Díaz, S. H. Oh, S. Shen, Saitoh, Shapley, Shen, Simon, Simon, Spergel, Spergel, Springel, Stadel, Stinson, Stoehr, Strigari, Strigari, Stringer, Swaters, Swaters, Sánchez-Janssen, T. Quinn, Tollerud, Tollerud, Tonini, van den Bosch, van der Wel, Viel, Vogelsberger, Wadsley, Walker, Walker, Walter, Willman, Zhang, Zolotov   +147 more
core   +1 more source

Interplay between Physics and Geometry in Balmer filaments: the Case of SN 1006 [PDF]

, 2018
The analysis of Balmer-dominated emission in supernova remnants is potentially a very powerful way to derive information on the shock structure, on the physical conditions of the ambient medium and on the cosmic-ray acceleration efficiency.
Bandiera, Rino, Knežević, Sladjana, Morlino, Giovanni, Raymond, John C.   +3 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

High Accuracy Profile Measurement With a New Virtual Multi-Probe Scanning System

IEEE Access, 2020
We present a novel virtual multi-probe scanning system and a new error separation method for the exact optical profile reconstruction. The system realized the multi-probe function by a single probe that fixed on a flexible hinge stage. The flexible hinge
Ning Chai, Ziqiang Yin, Jianhua Yao
doaj   +1 more source