Results 81 to 90 of about 687,840 (362)

The impact of building operations on urban heat/cool islands under urban densification: a comparison between naturally-ventilated and air-conditioned buildings [PDF]

, 2019
Many cities are suffering the effects of urban heat islands (UHI) or urban cool islands (UCI) due to rapid urban expansion and numerous infrastructure developments.
Duan, Shuangping, Li, Yuguo, Luo, Zhiwen, Yang, Xinyan   +3 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Damping of high rise buildings

IOP Conference Series: Materials Science and Engineering, 2019
Abstract High-rise construction acquires demand in Russia and abroad. New features are practiced in order to ensure the rigidity and stability of the building frame, to withstand wind and snow loads. It is about architectural and design features.
N I Zakieva, D V Grankina, D K Vasilieva, A D Tyutina   +3 more
openaire   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Features of construction control in the construction of high-rise buildings [PDF]

E3S Web of Conferences
With the continuous development of the social economy and the relentless progress of modernization, the construction industry has greatly contributed to the rapid development of urban planning.
Lapidus Azarij, Yan Jingjing, Telpiz Irina   +2 more
doaj   +1 more source

Green High-Rise Buildings

Revista de Gestão Social e Ambiental
Objectives: The study aims to critically analyze green high-rise buildings and their associated challenges based on peer-reviewed journals published between 2020 and 2024, in order to understand the effectiveness of sustainable practices applied to tall buildings.
openaire   +1 more source

Risky facilities: analysis of crime concentration in high-rise buildings [PDF]

This paper investigates the security of high rise high density accommodation at the Gold Coast – a premier Australian holiday destination. Surfers Paradise has one of the highest population densities in Australia at 3,279 persons per square kilometre and
Benjamin Hutchins, Danielle Reynald, John Rynne, Michael Townsley, Sacha Reid   +4 more
core