Results 121 to 130 of about 34,699,913 (290)

Time-Weighted Cumulative High-Sensitivity C-Reactive Protein and Risk of Cardiac Conduction Block: Findings from a Prospective Cohort

Journal of Inflammation Research
Mo Zhang,1,2,* Dou Shi,1,* Yixiu Chen,2,3 Yicheng Liao,2,3 Zhihui Liu,2,3 Renjie Fu,2,3 Yufeng Bian,2,3 Shuohua Chen,2 Haiyan Zhao,2 Honghong He,2 Changhao Zu,2 Chunlu Liu,2 Hongqiu Huo,2 Shouling Wu,2 Yuntao Wu2 1Graduate School, Hebei ...
Zhang M, Shi D, Chen Y, Liao Y, Liu Z, Fu R, Bian Y, Chen S, Zhao H, He H, Zu C, Liu C, Huo H, Wu S, Wu Y   +14 more
doaj  

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Association of High-Sensitivity C-Reactive Protein with Metabolic Syndrome and Transitions in Metabolic Status: A Combined Cross-Sectional and Cohort Study with Gender Differences in Chinese Adults

Journal of Inflammation Research
Yuyang Xiao,1– 3,* Xupeng Zhang,1,2,* Jia Wang,2 Xuchen Ma,2 Binyu Sun,2 Ying Li,1 Lei Chen,4 Yazhang Guo,5 Xiaoyue Li,6 Huirong Guo,7 Shanhu Yao,8 Yuexiang Qin1,9 1Health Management Medicine Center, The Third Xiangya Hospital of Central ...
Xiao Y, Zhang X, Wang J, Ma X, Sun B, Li Y, Chen L, Guo Y, Li X, Guo H, Yao S, Qin Y   +11 more
doaj  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

High sensitivity C-reactive protein as a predictive of intima-media thickness in patients with end-stage renal disease on regular hemodialysis

International Journal of General Medicine, 2019
Lestariningsih Lestariningsih,1 Suharyo Hardisaputro,2 Ayudyah Nurani,1 Damai Santosa,3 Gunawan Santoso41Division of Nephrology, Department of Internal Medicine, School of Medicine, Diponegoro University/Dr.
Lestariningsih L, Hardisaputro S, Nurani A, Santosa D, Santoso G   +4 more
doaj  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Life’s Essential 8 is inversely associated with high-sensitivity C-reactive protein

Scientific Reports
Life’s Essential 8 (LE8) is a score that includes modifiable risk factors for cardiovascular disease. Four health behaviors (diet, physical activity, nicotine exposure and sleep health) and four health factors (non-HDL cholesterol, blood glucose, blood ...
Lana Hebib, Ángel Herraiz-Adillo, Sara Higueras-Fresnillo, Daniel Berglind, Bledar Daka, Patrik Wennberg, Emil Hagström, Cecilia Lenander, Viktor H. Ahlqvist, Carl Johan Östgren, Karin Rådholm, Pontus Henriksson   +11 more
doaj   +1 more source