Results 111 to 120 of about 616,436 (300)

Neopterin as a Surrogate Marker for Coronary Artery Disease in Rheumatoid Arthritis

مجلة كلية الطب
Background: Rheumatoid arthritis is an inflammatory illness. A complication of Rheumatoid arthritis is mainly linked to the risk of cardiovascular disease.
Maryam K. Khaery, Rana A. Hamdi
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

A dose-response strategy reveals differences between normal-weight and obese men in their metabolic and inflammatory responses to a high-fat meal [PDF]

, 2014
A dose-response strategy may not only allow investigation of the impact of foods and nutrients on human health but may also reveal differences in the response of individuals to food ingestion based on their metabolic health status.
Buri, C., Vergères, G, Piya, Milan K. (R19111), Portmann, Reto, Kopf, Katrin Annika, Magali Chollet, Caroline Buri, Vionnet, Nathalie, Pralong, Franc̨ois, Laederach, K., Kopf-Bolanz, Katrin A., Chollet, Magali, Egger, L, Reto Portmann, Piya, Milan K, Gijs, Martin A., Buri, Caroline, Milan K. Piya, Egger, Lotti, Piya, Milan K., McTernan, P. G., Piya, M.K., Schwander, Flurina, Mcternan, Philip G., Gijs, MAM, Piya, MK, Gijs, Martin A M, Vionnet, N, Egger, L., Vergères, G., Schwander, F., McTernan, PG, Laederach, K, Lotti Egger, Portmann, R, Chollet, M, Kurt Laederach, Kopf-Bolanz, K.A., Gijs, M.A., Kopf-Bolanz, Katrin A, Schwander, F, Pralong, Francois P., Gijs, Martin A. M., Buri, C, Portmann, R., Vionnet, N., Philip G. McTernan, Chollet, M., McTernan, Philip G, Flurina Schwander, Vergeres, Guy, Nathalie Vionnet, François Pralong, Pralong, F, Kopf-Bolanz, KA, Pralong, F., Martin A.M. Gijs, McTernan, P.G., Guy Vergères, Laederach, Kurt, Katrin A. Kopf-Bolanz   +60 more
core   +1 more source

High sensitivity C-Reactive Protein is a Significant Predictor for Hypertension and Obesity in Iraqi Postmenopausal Women

مجلة كلية الطب, 2009
Background: several new inflammatory markers have emerged as strong predictors of cardiovascular disease in healthy and non-healthy subjects, one of these markers is hs-CRP, which has been proposed as independent risk factor for cardiovascular disease ...
Waleed Kh. Hussein, Ansam A. Al-Bayatti, Esam N. Salman   +2 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Genetic variation in Fcγ receptor IIa and risk of coronary heart disease : negative results from two large independent populations [PDF]

, 2009
Background The role of the Fcgamma receptor IIa (FcgammaRIIa), a receptor for C-reactive protein (CRP), the classical acute phase protein, in atherosclerosis is not yet clear.
Hoffmann, Michael Marcus, Karakas, M., Hoffmann, M.M., Khuseyinova, N., Illig, Thomas, Bernhard Winkelmann, Karakas, Mahir, Thomas Illig, Vollmert, C., Christa Meisinger, Koenig, W., Mahir Karakas, März, Winfried, Caren Vollmert, Winkelmann, Bernhard, Meisinger, C., Winkelmann, B., Hoffmann, Michael M., Khuseyinova, Natalie, Natalie Khuseyinova, Rothenbacher, D., Illig, T., Bernhard O Böhm, Böhm, Bernhard O., Vollmert, Caren, Koenig, Wolfgang, Böhm, Bernhard Otto, Rothenbacher, Dietrich, Marz, W., Michael M Hoffmann, Meisinger, Christine, König, Wolfgang, Meisinger, Christa, Böhm, B.O., Dietrich Rothenbacher, Wolfgang Koenig, Winkelmann, Bernhard Rudolf, Winfried März, Winkelmann, Bernhard R.   +38 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Study of high sensitive c-reactive protein in preeclampsia

International Journal of Clinical Biochemistry and Research, 2020
Introduction: Preeclampsia is a serious complication of the second half of pregnancy and is an important cause of maternal and perinatal morbidity and mortality. Measurement of circulatory inflammatory markers of endothelial cell dysfunction and inflammation may provide an alternative method of detecting women at high risk of delivery.
openaire   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source