Results 41 to 50 of about 34,699,913 (290)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

C-reactive protein is essential for innate resistance to pneumococcal infection. [PDF]

, 2014
No deficiency of human C-reactive protein (CRP), or even structural polymorphism of the protein, has yet been reported so its physiological role is not known.
Lawrence, Rachel A., Read, Kevin D., Aviva Petrie, Pepys, M B, Pepys, MB, Hutchinson, Winston L., LSHTM, Read, Kevin D, Raynes, JG, Read, KD, J. Brian Souza, Tennent, G A, Stephan Ellmerich, Loeffler, JM, Simons, JP, Rachel A. Lawrence, Simons, J Paul, Tennent, GA, John G. Raynes, Dundee, Glenys A. Tennent, Ellmerich, Stephan, Ellmerich, S, Tennent, Glenys A, Al-Shawi, Raya, Petrie, A, Tennent, Glenys A., Simons, J. Paul, Lawrence, R A, Jutta M. Loeffler, Lawrence, RA, Hutchinson, Winston L, J. Paul Simons, de Souza, J Brian, de Souza, J. Brian, Kevin D. Read, Raynes, John G., Raynes, J G, Read, K D, Mark B. Pepys, Hutchinson, WL, de Souza, JB, Loeffler, Jutta M, Petrie, Aviva, Al-Shawi, R, Pepys, Mark B., Lawrence, Rachel A, Raynes, John G, Loeffler, J M, de Souza, J B, Hutchinson, W L, Pepys, Mark B, Raya Al‐Shawi, Winston L. Hutchinson, Loeffler, Jutta M., Simons, J P, UCL   +56 more
core   +1 more source

Современные возможности определения и применения в клинике мономера С-реактивного белка [PDF]

, 2020
Aim. To develop a method for measuring circulating monomeric C-reactive protein and to determine the levels of C-reactive protein isoforms (native pentameric C-reactive protein and monomeric C-reactive protein) in patients with stable coronary artery ...
I. S. Melnikov, S. G. Kozlov, И. С. Мельников, М. Д. Зверева, О. С. Сабурова, O. S. Saburova, С. Г. Козлов, Z. A. Gabbasov, M. D. Zvereva, З. А. Габбасов   +9 more
core   +1 more source

Associations of High-Sensitivity C-Reactive Protein and Interleukin-6 with Depression in a Sample of Italian Adolescents During COVID-19 Pandemic

Neuropsychiatric Disease and Treatment, 2022
Maria Serra,1 Anna Presicci,2 Luigi Quaranta,3 Mariaclara Achille,4 Elvita Caputo,4 Silvia Medicamento,4 Francesco Margari,5 Federica Croce,5 Lucia Margari4 1Department of Pharmacy-Pharmaceutical Sciences, University of Bari “Aldo Moro”, Bari, Italy ...
Serra M, Presicci A, Quaranta L, Achille M, Caputo E, Medicamento S, Margari F, Croce F, Margari L   +8 more
doaj  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects [PDF]

, 2011
Background Chronic low-grade inflammation, characterized by elevated plasma levels of C-reactive protein (CRP), has been inversely associated with dispositional optimism.
Craen, A.J.M., Westendorp, R.G., P. Eline Slagboom, Anton J. M. de Craen, Kromhout, D., Johanna M. Geleijnse, Craen, A.J.M. de, Erik J. Giltay, Rius-Ottenheim, N., Rudi G. Westendorp, Geleijnse, J.M., Giltay, E.J., Slagboom, P.E., Mast, R.C. van der, Nathaly Rius-Ottenheim, Daan Kromhout, Frans G. Zitman, Roos C. van der Mast, Zitman, F.G., Rius Ottenheim, N.   +19 more
core   +1 more source

High sensitive quantitation of C-reactive protein.

Japanese Journal of Clinical Immunology, 1992
C-reactive protein (CRP)定量法は日常検査として普及している.我々は,高感度定量法としてLatex Photometric Immunoassay with near infrared turbidimetry (LPIA)を用い,客観的診断が困難であった,新生児の敗血症の早期診断の指標として低濃度域CRPの定量値についてモニタリングを試みた.最終臨床診断が敗血症であった33例, 36エピソードとコントロール群として21例25エピソードについて感度・特異度について検討した.
Nishida, Akira, Ohtani, Hideki
openaire   +2 more sources

High-sensitivity C-reactive protein as a potential marker for hypertension

Al-Azhar Assiut Medical Journal, 2018
Background Hypertension is a common, asymptomatic, readily detectable, and usually easily treatable disease that leads to lethal complications if left untreated. Hypertension results from the net effect of environmental and genetic factors. These factors
Elham Abd- Elsamie Ali, Mohamed Zakaria Abd Elrhman, Mohammed Ashraf Mahmoud   +2 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source