Results 81 to 90 of about 3,973 (221)

Integration of Single Pass Tangential Flow Filtration and High Performance Countercurrent Membrane Purification for Intensification of Monoclonal Antibody Processing

Biotechnology and Bioengineering, Volume 122, Issue 9, Page 2410-2419, September 2025.
ABSTRACT There is increasing interest in the development of intensified processes that can provide significant reductions in manufacturing costs for monoclonal antibody (mAb) products. This study examines the performance of an integrated membrane process that combines single‐pass tangential flow filtration (SPTFF) with high‐performance countercurrent ...
Mirko Minervini, Aylin Mohammadzadehmarandi, Ali Behboudi, Sheldon F. Oppenheim, Andrew L. Zydney   +4 more
wiley   +1 more source

An Off-Line DPPH-GC-MS Coupling Countercurrent Chromatography Method for Screening, Identification, and Separation of Antioxidant Compounds in Essential Oil

Antioxidants, 2020
Essential oils are an important source of natural antioxidants and multiple methods have been established for evaluation of their overall antioxidant activity, however, the antioxidant activities of their compounds are less investigated.
Xiang Wang, Guang-Lei Zuo, Chao-Yue Wang, Hyun Yong Kim, Soon Sung Lim, Sheng-Qiang Tong   +5 more
doaj   +1 more source

Techno‐economic analysis of membrane‐based continuous capture chromatography platforms for large‐scale antibody production

Biotechnology Progress, Volume 41, Issue 5, September/October 2025.
Abstract Continuous manufacturing platforms and membrane chromatography are process technologies with the potential to reduce production costs and minimize process variability in monoclonal antibody production. This study presents a simulation and optimization framework to perform techno‐economic analyses of these strategies.
Juan J. Romero, Eleanor W. Jenkins, Marc R. Birtwistle, Scott M. Husson   +3 more
wiley   +1 more source

Mathematical Model of \u3cem\u3eChlorella minutissima\u3c/em\u3e UTEX2341 Growth and Lipid Production Under Photoheterotrophic Fermentation Conditions [PDF]

, 2011
To reduce the cost of algal biomass production, mathematical model was developed for the first time to describe microalgae growth, lipid production and glycerin consumption under photoheterotrophic conditions based on logistic, Luedeking–Piret and ...
Hristova, Krassimira R., Rasa, Ehsan, Scow, Kate M., Tantayotai, Prapakorn, Yang, Jinshui, Yuan, Hong Li   +5 more
core   +1 more source

Optimization of multi‐column chromatography for capture and polishing at high protein load

Biotechnology Progress, Volume 41, Issue 5, September/October 2025.
Abstract Integrated Continuous Biomanufacturing reduces manufacturing costs while maintaining product quality. A key contributor to high biopharmaceutical costs, specifically monoclonal antibodies (mAbs), is chromatography. Protein A ligands are usually preferred but still expensive in the manufacturing context, and batch chromatography under‐utilizes ...
Tiago Castanheira Silva, Madelène Isaksson, Bernt Nilsson, Michel Eppink, Marcel Ottens   +4 more
wiley   +1 more source

Isolation and structure of rolliniastatin 2 : a new cell growth inhibitory acetogenin from Rollinia mucosa [PDF]

, 1989
Un nouvel inhibiteur de la croissance cellulaire, dénommé Rolliniastatine 2 a été isolé des graines de #Rollinia mucosa$ et sa structure déterminée.
Dufresne, C., Leet, J.E., Moretti, Christian, Pettit, G.R., Polonsky, J., Riesen, R., Schaufelberger, D., Schmidt, J.M., Smith, C.R.   +8 more
core  

An online NP-HPLC-DPPH method for the determination of the antioxidant activity of condensed polyphenols in cocoa [PDF]

, 2015
In PressUnroasted cocoa beans are rich in monomeric flavanols and particularly epicatechin-based proanthocyanidin oligomers, with the latter making up to 60% of the total polyphenol content.
Fischer, Norbert, Pedan, Vasilisa, Rohn, Sascha   +2 more
core   +1 more source

Bio‐Based Solvents Extraction and Enzyme‐assisted Recovery of Furan Fatty Acid From Ammonia‐Stabilized Hevea Latex

European Journal of Lipid Science and Technology, Volume 127, Issue 9, September 2025.
The latex of Hevea brasiliensis is rich in furan fatty acid (FuFA) esterified in both neutral and polar lipids. Bio‐based solvents to extract FuFA from ammonia‐stabilized latex was tested. Ethyl acetate worked best, especially with low‐ammonia content. Isopropanol was a good alternative. Lipases could also help to efficiently release FuFA. The findings
Chaisiri Kitpaosong, Siriluck Liengprayoon, Tucksin Lerksamran, Kittipong Rattanaporn, Bruno Barea, Achille Marchand, Frédéric Carrière, Hélène Launay, Thongchai Khaeduang, Pisamai Chantuma, Laurent Vaysse, Erwann Durand   +11 more
wiley   +1 more source

Screening and Isolating Major Aldose Reductase Inhibitors from the Seeds of Evening Primrose (Oenothera biennis)

Molecules, 2019
Aldose reductase (AR) is a drug target for therapies to treat complications caused by diabetes mellitus, and the development of effective AR inhibitors (ARIs) of natural origin is considered to be an attractive option for reducing these complications. In
Zhiqiang Wang, Shigang Shen, Ze Cui, Hailiang Nie, Dandan Han, Hongyuan Yan   +5 more
doaj   +1 more source

NIR Calibrations for Soybean Seeds and Soy Food Composition Analysis: Total Carbohydrates, Oil, Proteins and Water Contents [PDF]

, 2011
Conventional chemical analysis techniques are expensive, time consuming, and often destructive. The non-invasive Near Infrared (NIR) technology was introduced over the last decades for wide-scale, inexpensive chemical analysis of food and crop seed ...
I. C. Baianu, Jun Guo
core   +1 more source