Results 101 to 110 of about 25,285 (264)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Failure Analysis of Abnormal Cracking of the Track Circuit Reader Antenna Baffle for High-Speed Trains. [PDF]

Materials (Basel), 2023
Su C, Bi TT, Yang ZG.
europepmc   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Welding Characteristics of Laser-MIG Hybrid Welding of Arc-Welded Aluminum Profiles for High-Speed Trains. [PDF]

Materials (Basel), 2023
Du L, Yang Z, Wang X.
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Train-induced aerodynamic characteristics of vertical sound barriers influenced by several factors

Railway Engineering Science
Investigations into the aerodynamic properties of vertical sound barriers exposed to high-speed operations employ computational fluid dynamics. The primary focus of this research is to evaluate the influence of train speed and the distance (D) from the ...
Xiaowei Qiu, Xiaozhen Li, Jing Zheng, Ming Wang   +3 more
doaj   +1 more source

Study on the Dynamic Response of an Integrated Station-Bridge Station Building Jointly Constructed with a Subway

Buildings
With the integrated development of high-speed railways and urban underground rail transit, large high-speed railway station buildings are often seamlessly connected or even co-constructed with subway structures, forming a complex structural system that ...
Jianghao Liu, Yarui Xie, Chenxi Li, Deliang Zhou, Xiangrong Guo   +4 more
doaj   +1 more source

Evaluation of Thermal Fatigue Life and Crack Morphology in Brake Discs of Low-Alloy Steel for High-Speed Trains. [PDF]

Materials (Basel), 2022
Wang J, Chen Y, Zuo L, Zhao H, Ma N.
europepmc   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source