Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source
Deep-Feature-Matching-Based B-Spline Scale Correction Method for Nonlinear Distorted Images
IEEE AccessImages collected by linear scan cameras are nonlinearly stretched and compressed due to the speed regulation of high-speed trains. This condition changes the shape of objects and thus considerably increases the false and missed alarm rates for the ...
Luonan Chang, Hang Du
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A New Monitoring Technology for Bearing Fault Detection in High-Speed Trains. [PDF]
Sensors (Basel), 2023 Sun S, Zhang S, Wang W.
europepmc +1 more source
High-Speed Trains For California [PDF]
, 1992 This report represents that conclusions of the first year of IURD's study of the potential for a high-speed passenger train service in California. Seven previous studies have each dealt with a specific high-speed train technology; each attempted an evaluation, standardized so far as data permitted, of its technical and economic viability.The present ...
Hall, Peter, Leavitt, Daniel, Vaca, Erin
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RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Study on Acoustic Emission Characteristics of Fatigue Damage of A7N01 Aluminum Alloy for High-Speed Trains. [PDF]
Materials (Basel), 2023 Zhu R, Fang S, Sun W, Chi D.
europepmc +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Designing an Environmental Wind Tunnel Cooling System for High-Speed Trains with Air Compression Cooling and a Sensitivity Analysis of Design Parameters. [PDF]
Entropy (Basel), 2023 Zhuang J, Liu M, Wu H, Wang J.
europepmc +1 more source