Results 71 to 80 of about 25,212 (265)

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Integrated Optimization of Overnight Train Service Plans for High-Speed Rail Express: Adaptability of Two Typical Maintenance Windows

Transportation Research Interdisciplinary Perspectives
Given the rapidly growing demand for high-speed rail (HSR) express services, operating overnight trains emerges as a viable strategy to enhance service quality.
Ruhu Gao, Qianyu Wang, Xingjie Tie
doaj   +1 more source

Joint optimization of high-speed train timetables, speed levels and stop plans for increasing capacity based on a compressed multilayer space-time network

PLoS ONE, 2022
With the steady increase in passenger volume of high-speed railways in China, some high-speed railway sections have faced a difficult situation. To provide more transport services, it is necessary to add as many trains as possible in a section to ...
Angyang Chen, Xingchen Zhang, Junhua Chen, Zhimei Wang   +3 more
doaj  

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Dynamic Behavior of Railway Bridges Under High-Speed Traffic Loads

Romanian Journal of Transport Infrastructure
The interest on the dynamic behavior of railway bridges has grown in recent years due to the emergence of high-speed trains that induce a significant dynamic effect.
Iordan Petrescu, Mihaela Stan Oana, Marian Stănescu Răzvan   +2 more
doaj   +1 more source

Research on heat dissipation of brake disc in the semi-enclosed space under high-speed train based on fluid-solid-thermal coupling method

Case Studies in Thermal Engineering
The maximum operating speed of trains can reach 400 km/h, the temperature of brake discs will rise rapidly during emergency braking and brings safety hazards.
Shize Zheng, Jingxian Ding, Jianyong Zuo
doaj   +1 more source

Train Scheduling and Rolling Stock Assignment in High Speed Trains

Procedia - Social and Behavioral Sciences, 2014
The Train Timetabling Problem (TTP) has been widely studied for freight and passenger rail systems. A lesser effort has been devoted to the study of high-speed rail systems. A modeling issue that has to be addressed is to model departure time choice of passengers on railway services.
Espinosa Aranda, José Luis, García Ródenas, Ricardo, Cadarso Morga, Luis, Marín Gracia, Angel   +3 more
openaire   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Railways: Gateways Between East and West in Europe

Promet (Zagreb), 2003
Railways have connected various far-flung parts of Europefor much of the last two centuries. Recent years, however, haveseen a decline in direct international connections.
Hansjorg Kuster
doaj   +1 more source