Results 61 to 70 of about 25,212 (265)

Wheel Wear Predictions and Analyses of High-Speed Trains

Nonlinear Engineering, 2012
Wear of wheel profiles is one of the most critical issues affecting cost and performance of railway transportation systems. By altering the profile from the shape originally chosen by the designer, wear has a very large effect on vehicle dynamics, so ...
Jin X. C., Ahmadian
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Overviewing Braking Technology of the High-speed Trains

机车电传动, 2011
The relationship between the braking system and the security of the high-speed trains was expounded, comparative analysis about the brake modes and the corresponding braking performance as well as reviews of their domestic and oversea applications was ...
张建柏, 彭辉水, 倪大成, 刘雄
doaj  

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

aircraft and high-speed train substitution

, 2010
This book section is from A Dictionary of Transport Analysis: This concise and clearly focused Dictionary, with contributions by the leading authorities in their fields, brings order and clarity to a topic that can suffer from confusion over terminology and concepts.
openaire   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Research on Aerodynamic Noise Reduction for High-Speed Trains

Shock and Vibration, 2016
A broadband noise source model based on Lighthill’s acoustic theory was used to perform numerical simulations of the aerodynamic noise sources for a high-speed train.
Yadong Zhang, Jiye Zhang, Tian Li, Liang Zhang, Weihua Zhang   +4 more
doaj   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Adaptive Model Predictive Control for Cruise Control of High-Speed Trains with Time-Varying Parameters

Journal of Advanced Transportation, 2019
The cruise control of high-speed trains is challenging due to the presence of time-varying air resistance coefficients and control constrains. Because the resistance coefficients for high-speed trains are not accurately known and will change with the ...
Xiaokang Xu, Jun Peng, Rui Zhang, Bin Chen, Feng Zhou, Yingze Yang, Kai Gao, Zhiwu Huang   +7 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source