Results 41 to 50 of about 25,212 (265)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Вестник Научно-исследовательского института железнодорожного транспортаIntroduction. Reducing passenger journey duration at the current stage of transport development is a prerequisite for high-quality passenger service giving railways higher competitive advantage. In order to avoid significant investments, Russian Railways
E. V. Klimova
doaj +1 more source
Investigations for broadband internet within high-speed trains [PDF]
Advances in Radio Science, 2005 Broadband IP-based multimedia services are rapidly growing and there is the trend to use these services everywhere. Due to the fact that passengers in long distance high speed trains have a very comfortable environment to use their own terminal equipment,
I. Gaspard, G. Zimmermann
doaj
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Study of Aerodynamic Pressure of High-Speed Cross Trains In Tunnel [PDF]
International Journal of Railway ResearchIt is clear that the estimation and investigation of the aerodynamic peak pressure due to the passage of two high-speed cross trains intersecting in the tunnel is important because of its effects on passenger safety and tunnel structure.
Seyed Mohamad ehsan Ghafelebashi +2 more
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Promet (Zagreb), 2012 Considering the fierce debate on whether "maglev" or"on-the-trail" system should be applied to China's first high-speed railroad, this paper makes prospects about China's high--speed railroads.
Run Sha, Shao-Ying Chu
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Statistical delay distribution analysis on high-speed railway trains
Journal of Modern Transportation, 2019 The focus of this study is to explore the statistical distribution models of high-speed railway (HSR) train delays. Based on actual HSR operational data, the delay causes and their classification, delay frequency, number of affected trains, and space ...
Yuxiang Yang +4 more
doaj +1 more source