Results 31 to 40 of about 19,996,010 (288)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Dewey, Bruner, and Seas of Stories in the High Stakes Testing Debate [PDF]

open access: yes, 2012
This paper proposes that many of the questions surrounding high stakes testing being debated today are important, yet fall short of moving teachers, parents, students, administrators and legislators to think deeply about how optimal teaching and learning
Wilcox, Kristen Campbell
core  

The Source of Lake Wobegon

open access: yesNonpartisan Education Review, 2005
John J. Cannell's late 1980's “Lake Wobegon” reports suggested widespread deliberate educator manipulation of norm-referenced standardized test (NRT) administrations and results, resulting in artificial test score gains.
Richard P. Phelps
doaj  

Washback Effect of TEFL MA Exam on Iranian Lecturers’ Classroom Activities [PDF]

open access: yesApplied Research on English Language, 2018
Washback refers to the effect of testing on teaching and learning. The university entrance exam for Iranian MA candidates of Teaching English as a Foreign Language (hereinafter TEFL MA UEE) is a nationwide high-stakes test administered every year, and ...
Azadeh Pakzad, Hadi Salehi
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

The Source of Lake Wobegon (slide show)

open access: yesNonpartisan Education Review, 2007
John J. Cannell's late 1980's "Lake Wobegon" reports suggested widespread deliberate educator manipulation of norm-referenced standardized test (NRT) administrations and results, resulting in artificial test score gains.
Richard P. Phelps
doaj  

Flexibility at the Price of Volatility: Concurrent Calibration in Multistage Tests in Practice Using a 2PL Model

open access: yesFrontiers in Education, 2021
Multistage test (MST) designs promise efficient student ability estimates, an indispensable asset for individual diagnostics in high-stakes educational assessments.
Laura A. Helbling   +2 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Do outcomes from high stakes examinations taken in test centres and via live remote proctoring differ?

open access: yesComputers and Education Open, 2021
The onset of the COVID-19 pandemic brought with it the closure of many bricks-and-mortar testing centres and a concomitant move to the remote (online) proctoring of many credentialing exams that were scheduled to take place throughout 2020.
Gemma Cherry   +4 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

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