Results 81 to 90 of about 249,593 (301)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

Re-analysis of NAEP Math and Reading Scores in States with and without High-stakes Tests: Response to Rosenshine

open access: yesEducation Policy Analysis Archives, 2003
Here we address the criticism of our NAEP analyses by Rosenshine (2003). On the basis of his thoughtful critique we redid some of the analyses on which he focused. Our findings contradict his.
Audrey Amrein-Beardsley   +1 more
doaj  

IELTS and TOEFL Applicants’ Self-assessment and Actual Test Performance: A Mixed-Methods Study of Relationship and Variation [PDF]

open access: yesJournal of Modern Research in English Language Studies
Recent research on self-assessment (SA) has primarily dealt with its relationship with students’ scores. However, few studies have systematically explored SA in language proficiency tests.
Reza Rezvani, Farshad Khadivikia
doaj   +1 more source

Who wins and who loses from school accountability? The distribution of educational gain in English secondary schools [PDF]

open access: yes
In 1988 the UK government introduced greater accountability into the English state school sector. But the information that schools are required to make public on their pupil achievement is only partial.
Carol Propper   +3 more
core  

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Rural Elementary Administrators’ Views of High-Stakes Testing

open access: yesThe Rural Educator, 2018
This study examines how rural elementary school administrators perceive the effects of high-stakes testing in comparison to suburban and urban elementary administrators.
Robert J. Egley, Brett D. Jones
doaj   +1 more source

Preparing for High-Stakes Testing [PDF]

open access: yesTheory Into Practice, 2003
The passage of the No Child Left Behind Act has spotlighted testing and accountability in U.S. public schools. This federal statute calls for a dramatic expansion of state-level high-stakes testing. Educators need to prepare students for these tests in ways that do not detract from real learning. In addition, school practitioners must become assessment
openaire   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

open access: yesFEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu   +10 more
wiley   +1 more source

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