Results 271 to 280 of about 11,387,151 (316)
Some of the next articles are maybe not open access.
High throughput screening for autophagy
2021Robotized high throughput screening allows for the assessment of autophagy in a large number of samples. Here, we describe a drug discovery platform for the phenotypic identification of novel autophagy inducers by means of automated cell biology workflows employing robotized cell culture, sample preparation and data acquisition.
Sabrina, Forveille +5 more
openaire +2 more sources
2010
SuperSAGE is a method of digital gene expression profiling that allows isolation of 26-bp tag fragments from expressed transcripts. Combined with the ultrahigh-throughput sequencing technologies, SuperSAGE enables analysis of millions of transcripts with lower cost and reduced effort and time.
Hideo, Matsumura +6 more
openaire +2 more sources
SuperSAGE is a method of digital gene expression profiling that allows isolation of 26-bp tag fragments from expressed transcripts. Combined with the ultrahigh-throughput sequencing technologies, SuperSAGE enables analysis of millions of transcripts with lower cost and reduced effort and time.
Hideo, Matsumura +6 more
openaire +2 more sources
High-Throughput Replica Optics
SPIE Proceedings, 1988Some simple formulas are derived to calculate the maximum effective area that can be obtained by Kirkpatrick-Baez, Wolter, and conical x-ray telescopes in those cases for which that area is limited by the focal length. Electroforming and epoxy replication techniques are reviewed, and the design and production technology chosen for the high throughput ...
openaire +2 more sources
The rise of high-throughput computing
Frontiers of Information Technology & Electronic Engineering, 2018In recent years, the advent of emerging computing applications, such as cloud computing, artificial intelligence, and the Internet of Things, has led to three common requirements in computer system design: high utilization, high throughput, and low latency. Herein, these are referred to as the requirements of ‘high-throughput computing (HTC)’.
Ninghui Sun, Yungang Bao, Dongrui Fan
openaire +1 more source
High-throughput screening for biocatalysts
Current Opinion in Biotechnology, 2001Recent progress in high-throughput enzyme assays includes new examples of fluorogenic and chromogenic substrates, fluorescence resonance energy transfer substrates, and applications of the pH and pM indicator methods. Recent developments of Horeau's pseudo-enantiomer derivatisation method to screen enantioselectivities in high-throughput have also been
Wahler D, Reymond JL
openaire +3 more sources
High-throughput zebrafish histology
Methods, 2006The morphological effects of mutation and disease are often critical to our understanding of normal and abnormal function. The power and popularity of zebrafish as a forward and reverse genetic vertebrate model system, combined with its small size, have made it an ideal model in which to study the genetics of histologically scorable phenotypes.
Nicole A, Sabaliauskas +7 more
openaire +2 more sources
2007
There are many genetic variations in the human genome. The most abundant form of genetic variation is the single nucleotide polymorphism (SNP). SNPs are thought to be responsible for observable differences in biological processes among individuals of a population. Genetic association studies utilizing SNP markers are expected to allow identification of
openaire +2 more sources
There are many genetic variations in the human genome. The most abundant form of genetic variation is the single nucleotide polymorphism (SNP). SNPs are thought to be responsible for observable differences in biological processes among individuals of a population. Genetic association studies utilizing SNP markers are expected to allow identification of
openaire +2 more sources
2009
Surface plasmon resonance (SPR) imaging technique is label free, real-time, and high-throughput analysis method for interaction studies with array format. The application of SPR imaging for the small molecule arrays, which were fabricated by photoaffinity crosslinking, can be the first screening step for reverse chemical genomics.
Motoki, Kyo +3 more
openaire +2 more sources
Surface plasmon resonance (SPR) imaging technique is label free, real-time, and high-throughput analysis method for interaction studies with array format. The application of SPR imaging for the small molecule arrays, which were fabricated by photoaffinity crosslinking, can be the first screening step for reverse chemical genomics.
Motoki, Kyo +3 more
openaire +2 more sources
Overview of High‐Throughput Screening
Current Protocols in Pharmacology, 2009AbstractHigh‐throughput screening (HTS) is a key process used in drug discovery to identify hits from compound libraries that may become leads for medicinal chemistry optimization. This updated overview discusses the utilization of compound libraries, compounds derived from combinatorial and parallel synthesis campaigns and natural product sources ...
Michael, Entzeroth +2 more
openaire +2 more sources
High-throughput antibody isolation
Current Opinion in Chemical Biology, 2001To define the proteome of an organism, there is a need for robust and reproducible methods for the quantitative detection of all the polypeptides in a cell. High-density arrays of receptors specific for each of the polypeptides in a complex sample hold great promise for the analysis of complex protein mixtures.
A, Hayhurst, G, Georgiou
openaire +2 more sources