Results 131 to 140 of about 1,415 (165)
Food Safety and Health, EarlyView.Representation of grass pea consumption in drought‐stricken sub‐Saharan Africa sustains nutrition, but excess β‐ODAP exposure due to multiple reasons triggers neurolathyrism, a progressive neurotoxic disorder. ABSTRACT Neurolathyrism is a progressive motor neuron disease due to the consumption of Lathyrus sativus (grass pea) over long periods.
Biruk Demisse Ayalew +12 more
wiley +1 more source
Native grass breeding: Priority needs and strategic approaches
Grassland Research, EarlyView.The key needs and breeding strategies of native grass. Abstract Native grasses possess extensive ecological adaptability, such as cold, drought, and salt tolerance, and tolerance to poor soil conditions. They play a crucial role in ensuring food security and ecological security.
Xueming Dong, Wenxian Liu, Zhipeng Liu
wiley +1 more source
International Journal of Cancer, EarlyView.Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer +11 more
wiley +1 more source
International Journal of Cancer, EarlyView.Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia +4 more
wiley +1 more source
International Journal of Cancer, EarlyView.Mutual exclusivity and co‐occurrence of oncogenic mutations reflect functional antagonism or dependence and may inform therapeutic strategies. However, most studies overlook variant‐level patterns. In this comprehensive, cross‐cohort analysis of BRAF, KRAS, and EGFR mutation subtypes, the most significant mutual exclusivity pairs overlapped with ...
Freya Vaeyens +14 more
wiley +1 more source
Computational Intelligence Accelerates CRISPR‐Cas‐Based Diagnostic Design
iLABMED, EarlyView.Computational intelligence, including pangenome‐guided target mining, machine‐learning‐based guide RNA optimization, and autonomous AI agents, is shifting CRISPR diagnostic design from empirical screening to systematic, data‐driven engineering and accelerating the path from pathogen discovery to deployable diagnostics.
Hengyu Wang +3 more
wiley +1 more source
Integrative Conservation, EarlyView.This study reconstructs the phylogeny of the Javan Hawk‐Eagle (Nisaetus bartelsi) within the subfamily Aquilinae using Maximum Likelihood and Bayesian Inference algorithms on a blood sample and GenBank data. The analysis reveals that the sampled genus Nisaetus forms a monophyletic group. Furthermore, N. bartelsi occupies a sister‐taxon of N.
Almas Lathifatul Ula +3 more
wiley +1 more source
Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials
iNew Medicine, EarlyView.ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong +5 more
wiley +1 more source
Integrated one‐pot CRISPR‐Cas detection: Addressing strategies and future prospects
Interdisciplinary Medicine, EarlyView.Integrated one‐pot CRISPR‐Cas detection significantly simplifies workflows, reduces cross‐contamination risks, and shortens turnaround times, making it highly suitable for point‐of‐care testing (POCT) and resource‐limited settings. Key challenges include system compatibility issues between Cas proteins and isothermal amplification, limited multiplexing
Jian Zhou +6 more
wiley +1 more source