Results 141 to 150 of about 1,415 (165)
Miniaturized Droplet‐Based Adaptation of the Ames Test for High‐Throughput Mutagenicity Assessment
Journal of Applied Toxicology, EarlyView.ABSTRACT This work presents the first demonstration of a tube‐based droplet microfluidic implementation of the Ames test, bridging single‐droplet resolution with regulatory genotoxicity testing. The Ames test is a cornerstone assay for detecting mutagenicity, but conventional plate‐ and well‐based formats suffer from high reagent consumption, low ...
Jialan Cao +3 more
wiley +1 more source
Experiencing 50 Years of Synergistic Development in Structural Biology and Enzymology
Journal of the Chinese Chemical Society, EarlyView.Picture of Sunney Chan with Academia Sinica (AS) President James C. Liao and three Vice Presidents: Shin‐Kun Peng (left one), Tang K. Tang (right one), and Mei‐Yin Chou (right 2), taken at the annual Chinese New Year's Banquet of AS, February 7, 2025. This was likely Sunney's last appearance in formal activities of AS.
Ming‐Daw Tsai
wiley +1 more source
Journal of Clinical Laboratory Analysis, EarlyView.Identifying novel treatments for diabetic management is always a competitive research topic all over the world. PPAR‐γ is one of the key regulators involved in glucose and lipid metabolism and improves insulin sensitivity and glucose homeostasis. This study investigated the impacts of 639 traditional Chinese medicine (TCM) on PPAR‐γ gene promoter ...
Mingyuan Dou +9 more
wiley +1 more source
Microbial communities and functional diversity in seafood
JSFA reports, EarlyView.Abstract Functional diversity encompasses ecosystem processes that enhance adaptability to environmental change. This study explores the diversity of microorganisms associated with seafood. In this paper, we present our knowledge of microbial diversity in relation to seafood.
Christian Larbi Ayisi +3 more
wiley +1 more source
Underground Lag: Fungal Community and Edaphic Legacies After Disturbance
Land Degradation &Development, EarlyView.ABSTRACT Páramos are neotropical mountain ecosystems that regulate water and store large amounts of carbon, but are increasingly degraded by agriculture and grazing. Although native vegetation often recolonizes after abandonment, belowground recovery remains poorly understood.
Wilmer Dajhan Navarrete‐López +6 more
wiley +1 more source
Limnology and Oceanography: Methods, EarlyView.Abstract Assigning taxonomic identity and thus assessing taxonomic diversity in gelatinous zooplankton is challenging due to their fragility and difficult preservation. Formalin fixation compromises DNA integrity, while flash‐freezing, ethanol, and acetone preservation affect morphological features. In this study, we developed a methodological protocol
Claudia Traboni +4 more
wiley +1 more source
Mass Spectrometry Reviews, EarlyView.ABSTRACT Top‐down proteomics (TDP) characterizes proteoforms in cells, tissues, and biofluids, in discovery mode and on a global scale, requiring analytical tools with high peak capacity for proteoform separation and high sensitivity for proteoform detection, given the extremely high proteoform complexity and wide proteoform concentration dynamic range.
Guijie Zhu +5 more
wiley +1 more source
Mapping Causal Biology: Mendelian Randomization in the Era of Big Data
Med Research, EarlyView.Mendelian randomization (MR) leverages genetic variants to mitigate confounding biases in causal inference. This review systematically maps MR's methodological evolution, highlights its expanding applications in epidemiology and drug target validation, and outlines future directions for overcoming current biases through dynamic, multi‐omics, and cross ...
Xuanlu Shen +10 more
wiley +1 more source
Omics GWAS: A Multi‐Omics Integrative Analysis Platform for Genome‐Wide Association Studies
Med Research, EarlyView.ABSTRACT With the rapid advancement of genome‐wide association studies (GWAS), downstream analyses of GWAS data have become essential for elucidating the genetic mechanisms that underlie complex diseases. However, current post‐GWAS analyses face numerous challenges, including heterogeneous data formats, challenges in multi‐omics integration, and ...
Xu Zhang +8 more
wiley +1 more source
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