Results 191 to 200 of about 149,249 (267)

C‐6‐Modified 2‐F‐Fucose Derivatives as Inhibitors of Fucosyltransferases

ChemBioChem, EarlyView.
A series of C6‐modified guanosine‐diphosphate‐2‐F‐fucose analogs and corresponding prodrugs are designed, synthesized, and biologically evaluated as inhibitors of cellular fucosylation. Certain analogs potently inhibit fucosyltransferases (FUT) FUT1, 3, 6, and 9 while showing minimal activity for FUT8, highlighting the potential for selective FUT ...
Yanyan Liu, Geert‐Jan Boons
wiley   +1 more source

A novel high-throughput single-cell DNA sequencing method reveals hidden genomic heterogeneity in the unicellular eukaryote Leishmania

Negreira GH, Monsieurs P, Dujardin J, Domagalska MA.   +3 more
europepmc   +1 more source

Molecular advances in transfusion medicine: a narrative review. [PDF]

Front Med (Lausanne)
Arishi WA, Yaqinuddin A, Sajid MR.
europepmc   +1 more source

Method Overview for Discovering ATE1 Substrates and their Arginylation Sites

ChemBioChem, EarlyView.
Arginylation is a decades‐old post‐translational modification but is inherently difficult to study. A plurality of methods have been developed and deployed to uncover the biology and substrates of this modification. This review covers the history, major advancements, and substrates discovered over the course of six decades.
Richard M. Searfoss, Benjamin A. Garcia, Zongtao Lin   +2 more
wiley   +1 more source

Unlocking Biomolecule Modification with Light‐Promoted Photocatalyst‐Free Approaches: Current Tools, Challenges, and Perspectives

ChemistryEurope, EarlyView.
This Perspective focuses on photocatalyst‐free, photoinduced modifications of biomolecules, emphasizing transformations mediated by electron donor–acceptor complexes. Mechanistic aspects, current limitations, and future opportunities are discussed, providing insight into the field of bioconjugation.
Milene Hornink, Maria Eduarda C. Thedy, Eugénie Romero, Gary A. Molander   +3 more
wiley   +1 more source

Genetic distances and genome wide population structure analysis of a grain amaranth (Amaranthus hypochondriacus) diversity panel using genotyping by sequencing. [PDF]

Sci Rep
Chauhan R, Prabhakaran S, Tiwari A, Joshi D, Chandora R, Taj G, Jahan T, Singh SP, Jaiswal JP, Joshi R, Kumar A, Pandey D.   +11 more
europepmc   +1 more source

Identification of neural crest and melanoma cancer cell invasion and migration genes using high‐throughput screening and deep attention networks

Developmental Dynamics, EarlyView.
Abstract Background Cell migration and invasion are well‐coordinated in development and disease but remain poorly understood. We previously showed that the neural crest (NC) cell migratory wavefront shares a 45‐gene panel with other cell invasion phenomena.
J. C. Kasemeier‐Kulesa, S. Martina Perez, R. E. Baker, P. M. Kulesa   +3 more
wiley   +1 more source

Highly replicated experiments studying complex genotypes using nested DNA barcodes. [PDF]

G3 (Bethesda)
Monge M, Giovanetti SM, Ravishankar A, Sadhu MJ.   +3 more
europepmc   +1 more source

Which global circulation model works best for my region? Concordance with genetic data for a Neotropical shrew

Ecography, EarlyView.
Copious questions in global change biology require estimates of climatic suitability for species in the past or future, often via transfers of ecological niche models (ENMs) using outputs from global circulation models (GCMs). However, available GCMs differ markedly, affecting hindcasts and forecasts of species potential distributions. We propose using
Lázaro Guevara, Amaranta Zugasti‐Mateos, Gonzalo E. Pinilla‐Buitrago, Miguel Ángel León‐Tapia, Ella Vázquez‐Domínguez, Robert P. Anderson   +5 more
wiley   +1 more source

The quest for a complete understanding of the human genome. [PDF]

Genome Med
Abou Tayoun A, Ali H, Mokrab Y.
europepmc   +1 more source