Results 231 to 240 of about 271,712 (303)

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Rapid Authentication of Flowers of <i>Panax ginseng</i> and <i>Panax notoginseng</i> Using High-Resolution Melting (HRM) Analysis. [PDF]

Molecules
Wang M, Li W, Zuo Y, Jiang Q, Li J, Zhang W, Meng X.   +6 more
europepmc   +1 more source

Alterations in Metabolites Associated With Umbilical Cord Blood in Monozygotic Twins Discordant for Congenital Heart Disease

Pediatric Discovery, EarlyView.
This study found that the metabolomic signature of umbilical venous cord blood in congenital heart disease (CHD) differs from that of healthy monozygotic (MZ) co‐twins. Dysregulation of metabolic pathways like glucose, lipid, and amino acid metabolism, along with altered metabolites, helps understand CHD predisposition.
Fang Xiang, Xiao Yuan, Yi Yang, Philip N. Baker, Mark D. Kilby, Chao Tong, Xi Yuan   +6 more
wiley   +1 more source

Evaluation of optimal pooling strategies for Mpox virus genomic surveillance using the Illumina Viral Surveillance Panel on the iSeq100 platform in outbreak settings. [PDF]

BMJ Public Health
Nguinkal JA, Melo AM, Nzoyikorera N, Jurgen M, Affara M, Gehre F.   +5 more
europepmc   +1 more source

Genetically predicted KIR2DS4 mediate the association between gut microbe K10 and osteoporosis fractures: A mediation Mendelian randomization study

PM&R, EarlyView.
Abstract Background Osteoporosis fractures pose a significant public health concern, leading to substantial morbidity and mortality rates. The emerging evidence on the potential link between gut microbiota, proteins, and osteoporosis fractures suggests a complex relationship that warrants further investigation.
Qiong Wang, Qing Kuang, Cheng Chen, Binru Wang, Wei Xiang, Xinming Li, Jianjiao Mou   +6 more
wiley   +1 more source

Harnessing genomic resources for passion fruit improvement: Progress and prospects. [PDF]

Plant Genome
Fulara K, Garg V, Sun X, Ford R, Dillon N, Topp B, Henry RJ, Alam M, Varshney RK.   +8 more
europepmc   +1 more source

Life after herbarium digitisation: Physical and digital collections, curation and use

PLANTS, PEOPLE, PLANET, EarlyView.
Societal Impact Statement Collections of dried plant specimens (herbaria) provide an invaluable resource for the study of many areas of scientific interest and conservation globally. Digitisation increases access to specimens and metadata, enabling efficient use across a broad spectrum of research.
Alan James Paton, Gabriel K. Ameka, Alexandre Antonelli, Alex Asase, Russell L. Barrett, Ann Bogaerts, Domingos Cardoso, Mark Carine, Alastair Culham, Syadwina H. Dalimunthe, Nina Davies, Sofie De Smedt, Sebebe Demissew, Rafaela Campostrini Forzza, Quentin Groom, Elspeth M. Haston, Abdulrokhman Kartonegoro, Paul Kersey, Isabel Larridon, Jana Leong‐Škorničková, Lucia G. Lohmann, Jehova Lourenco Jr., Hannah McPherson, Muthama Muasya, Nicky Nicolson, Marcelo Pace, Jack F. Plummer, Hélène Ralimanana, Himmah Rustiami, Hervé Sauquet, Emily B. Sessa, Eric Smets, Alex Sumadijaya, Jordan Teisher, Daniel C. Thomas, Eka F. Tihurua, Janine E. Victor, Sarah T. Wagner, Quiang Wang, Andrew Young   +39 more
wiley   +1 more source

Incorporating environmental DNA metabarcoding for improved benthic biodiversity and habitat mapping

Remote Sensing in Ecology and Conservation, EarlyView.
Seafloor imagery is commonly used to collect information about the distribution of benthic organisms in order to generate habitat and biodiversity maps. Recent advances in genomics (e.g., environmental DNA; eDNA) show potential to complement video surveys for habitat mapping, but there have been few examples testing this.
Rylan J. Command, Shreya Nemani, Benjamin Misiuk, Mehrdad Hajibabaei, Nicole Fahner, Emily Porter, Greg Singer, Beverly McClenaghan, Katleen Robert   +8 more
wiley   +1 more source

Understanding Neurodegenerative Diseases From the -Omics Perspective: Lessons Learnt. [PDF]

Ann Neurol
Ibanez L, Pottier C, Beric A, Western D, Ali M, Cruchaga C.   +5 more
europepmc   +1 more source

Light‐Guided Molecular Patterning for High‐Throughput Single‐Molecule Mechanical Characterization

Small, EarlyView.
A light‐guided molecular patterning method is presented for high‐throughput single‐molecule characterization. The approach enables scalable and accessible molecular patterning without specialized lithography equipment. Patterned surfaces are compatible with downstream biophysical assays, demonstrated by magnetic tweezers and flow‐based single‐molecule ...
Hansol Choi, Andrew Ward, Wesley P. Wong
wiley   +1 more source