Results 111 to 120 of about 16,254,290 (323)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

M2F-Net: A Deep Learning-Based Multimodal Classification with High-Throughput Phenotyping for Identification of Overabundance of Fertilizers

, 2023
 M2F-Net: A Deep Learning-Based Multimodal Classification with High-Throughput Phenotyping for Identification of Overabundance of Fertilizers 
J. Dhakshayani, B. Surendiran, Surendiran, B. (12546538), Dhakshayani, J. (16382076)   +3 more
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

High‐throughput CRISPRi phenotyping identifies new essential genes in Streptococcus pneumoniae

Molecular Systems Biology, 2017
Genome‐wide screens have discovered a large set of essential genes in the opportunistic human pathogen Streptococcus pneumoniae. However, the functions of many essential genes are still unknown, hampering vaccine development and drug discovery.
Xue Liu, Clement Gallay, Morten Kjos, Arnau Domenech, Jelle Slager, Sebastiaan P van Kessel, Kèvin Knoops, Robin A Sorg, Jing‐Ren Zhang, Jan‐Willem Veening   +9 more
doaj   +1 more source

Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen

Disease Models & Mechanisms, 2014
The Mouse Genetics Project (MGP) at the Wellcome Trust Sanger Institute aims to generate and phenotype over 800 genetically modified mouse lines over the next 5 years to gain a better understanding of mammalian gene function and provide an invaluable ...
Hibret A. Adissu, Jeanne Estabel, David Sunter, Elizabeth Tuck, Yvette Hooks, Damian M. Carragher, Kay Clarke, Natasha A. Karp, Sanger Mouse Genetics Project, Susan Newbigging, Nora Jones, Lily Morikawa, Jacqueline K. White, Colin McKerlie   +13 more
doaj   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Acknowledgement to Reviewers of High-Throughput in 2017

, 2018
Peer review is an essential part in the publication process, ensuring that High-Throughput maintains high quality standards for its published papers [...
High-Throughput Editorial Office
core   +1 more source

High throughput phenotyping of morpho-anatomical stem properties using X-ray computed tomography in sorghum

Plant Methods, 2018
Background In bioenergy/forage sorghum, morpho-anatomical stem properties are major components affecting standability and juice yield. However, phenotyping these traits is low-throughput, and has been restricted by the lack of a high-throughput ...
Francisco E. Gomez, Geraldo Carvalho, Fuhao Shi, Anastasia H. Muliana, William L. Rooney   +4 more
doaj   +1 more source

Integrating High-Throughput Phenotyping and Statistical Genomic Methods to Genetically Improve Longitudinal Traits in Crops

Frontiers in Plant Science, 2020
The rapid development of remote sensing in agronomic research allows the dynamic nature of longitudinal traits to be adequately described, which may enhance the genetic improvement of crop efficiency.
F. Moreira, H. Oliveira, J. Volenec, K. Rainey, L. Brito   +4 more
semanticscholar   +1 more source