Results 111 to 120 of about 62,485 (295)

Estimating Biomass and Canopy Height With LiDAR for Field Crop Breeding

Frontiers in Plant Science, 2019
Above-ground biomass (AGB) is a trait with much potential for exploitation within wheat breeding programs and is linked closely to canopy height (CH). However, collecting phenotypic data for AGB and CH within breeding programs is labor intensive, and in ...
James D. C. Walter, James D. C. Walter, James Edwards, James Edwards, Glenn McDonald, Haydn Kuchel, Haydn Kuchel   +6 more
doaj   +1 more source

Cardiac‐Derived ECM Microspheres for Enhanced hiPSC‐CMs Maturation

Advanced Functional Materials, EarlyView.
Cardiac extracellular matrix microspheres derived from decellularized porcine heart provide a biomimetic 3D microenvironment for human induced pluripotent stem cell–derived cardiomyocytes (hiPSC‐CMs). This platform supports short‐ and long‐term culture, enhances structural organization, and promotes electrophysiological and functional maturation of ...
Jiazhu Xu, Joel Aboagye, Marcella Edwards, Nick Rogozinski, Yufeng Wen, Angello Huerta Gomez, Zui Pan, Ge Zhang, Huaxiao Yang, Yi Hong   +9 more
wiley   +1 more source

Erratum: Author Correction: Identification of genes required for eye development by high-throughput screening of mouse knockouts. [PDF]

, 2019
[This corrects the article DOI: 10.1038/s42003-018-0226-0.]
Adissu, Hibret, Asomugha, Chinwe, Beaudet, Arthur L, Berberovic, Zorana, Bohat, Ritu, Bower, Lynette, Braun, Robert E, Brown, Steve DM, Cater, Heather, Clary, David, Clementson-Mobbs, Sharon, Cooper, Ann, de Angelis, Martin Hrabe, Dickinson, Mary E, Edwards, Sydney G, Eskandarian, Mohammed, Flenniken, Ann M, Fletcher, Colin, Flicek, Paul, Gallegos, Juan J, Gao, Xiang, Griffey, Stephen M, Heaney, Jason D, Herault, Yann, Hsu, Chih-Wei, Imai, Denise M, International Mouse Phenotyping Consortium, Joynson, Russell, Justice, Monica J, Kalaga, Sowmya, Karp, Natasha, Kent Lloyd, KC, Krebs, Mark P, Kumar, Vivek, Leonard, Brian C, Mallon, Ann-Marie, Mason, Jeremy, McKerlie, Colin, Meehan, Terrence F, Meziane, Hamid, Moore, Bret A, Moore, Mark, Moshiri, Ala, Murphy, Christopher J, Murray, Stephen A, Newbigging, Susan, Nishina, Patsy M, Nutter, Lauryl MJ, Owen, Celeste, Parkinson, Helen, Philip, Vivek, Ramirez-Solis, Ramiro, Reilly, Christopher, Roux, Michel J, Santos, Luis, Seavitt, John R, Sebbag, Lionel, Seong, JK, Smedley, Damian, Stewart, Michelle, Straiton, Ewan, Suzuki, Tomohiro, Svenson, Karen L, Thomasy, Sara M, Tocchini-Valentini, Glauco, Udensi, Uchechukwu, Wakana, Shigeharu, Wells, Sara, White, Jacqueline K, Wurst, Wolfgang   +69 more
core  

VIVID: A qPCR‐Based Platform for Sensitive and Quantitative In Vivo Tracking of Extracellular Vesicles

Advanced Functional Materials, EarlyView.
This study introduces VIVID (Vesicle In Vivo Identification using DNA), a qPCR‐based platform that tracks PCR‐amplifiable DNA tags loaded in the EVs for accurate and quantifiable EV biodistribution in vivo. ABSTRACT Extracellular vesicles (EVs) represent promising carriers for nucleic acid therapeutics, offering advantages over synthetic nanoparticles ...
Oscar Boyadjian, Talin Ebrahimian, Jonathan Miranda O'Connor, Janusz Rak, Stephanie Lehoux, Maryam Tabrizian   +5 more
wiley   +1 more source

High‐Resolution and Real‐Time In Situ Generation of Cellular Spheroids by Laser‐Assisted Bioprinting for Guided Microvascularization

Advanced Functional Materials, EarlyView.
Micro‐injection laser‐assisted bioprinting enables ultrafast and precise patterning of small endothelial cell spheroids by injecting a highly concentrated single‐cell suspension into GelMA/ColMA hydrogels. In co‐culture with fibroblasts, controlled pre‐vasculogenic network formation is obtained at microscale resolution.
Charles Handschin, Katharina Wulz, Clotilde Jugie, Marie‐Laure Stachowicz, Shane Fennell, Aurélien Mazet, Malou Lea, Nathalie Dusserre, Jean‐Christophe Fricain, Hugo Oliveira   +9 more
wiley   +1 more source

Swelling‐Programmed Topographical Guidance for Dynamic Spheroid Self‐Assembly via a Mechanochemical Hydrogel Niche

Advanced Functional Materials, EarlyView.
A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam, Seon Yeong Chae, Young Woo Kwon, Hye Jin Heo, Hye Rin Lee, Ji Hyeok Lee, Dong‐Wook Han, Yun Hak Kim, Suck Won Hong   +8 more
wiley   +1 more source

Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels

Advanced Healthcare Materials, EarlyView.
We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa, Lineta Stonkute, Sara Trujillo, Mariana Azevedo Gonzalez Oliva, Francis Burton, Matthew J. Dalby, Oana Dobre, Godfrey Smith, Manuel Salmeron‐Sanchez   +8 more
wiley   +1 more source

Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen

Disease Models & Mechanisms, 2014
The Mouse Genetics Project (MGP) at the Wellcome Trust Sanger Institute aims to generate and phenotype over 800 genetically modified mouse lines over the next 5 years to gain a better understanding of mammalian gene function and provide an invaluable ...
Hibret A. Adissu, Jeanne Estabel, David Sunter, Elizabeth Tuck, Yvette Hooks, Damian M. Carragher, Kay Clarke, Natasha A. Karp, Sanger Mouse Genetics Project, Susan Newbigging, Nora Jones, Lily Morikawa, Jacqueline K. White, Colin McKerlie   +13 more
doaj   +1 more source

Computational Modeling Meets 3D Bioprinting: Emerging Synergies in Cardiovascular Disease Modeling

Advanced Healthcare Materials, EarlyView.
Emerging advances in three‐dimensional bioprinting and computational modeling are reshaping cardiovascular (CV) research by enabling more realistic, patient‐specific tissue platforms. This review surveys cutting‐edge approaches that merge biomimetic CV constructs with computational simulations to overcome the limitations of traditional models, improve ...
Tanmay Mukherjee, Mehdi Salar Amoli, Sarah Rezapourdamanab, Lama Rita El Shammas, Martin L. Tomov, Emilio A. Mendiola, Vahid Serpooshan, Reza Avazmohammadi   +7 more
wiley   +1 more source

Microfluidic Modeling of Macrophage‐Induced Cardiac Inflammation Using NF‐κB Reporter Cardiomyocytes

Advanced Healthcare Materials, EarlyView.
A cardiac inflammation model was developed to enable real‐time analysis of macrophage‐cardiomyocyte interactions using NF‐κB‐reporter cardiomyocytes and a microfluidic co‐culture system. A MATLAB‐based model was implemented to optimize cell density and medium resupply based on TNFα diffusion kinetics. Activation thresholds and stress responses in NF‐κB‐
Chao Liu, Xi Rui Qiang Lu, Seoyoung Jeong, Douglas H. Wu, Rodrigo A. Somoza, Parameswaran Ramakrishnan, Samuel E. Senyo   +6 more
wiley   +1 more source