Results 101 to 110 of about 615,917 (326)

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

An automatable, field camera track system for phenotyping crop lodging and crop movement

HardwareX, 2018
High throughput phenotyping systems enable rapid data collection for plant breeders. Some plant traits such as lodging, or the breaking and falling over of plant stems under wind stress, are complex and not easily measured through existing high ...
Alexander Q. Susko, Fletcher Gilbertson, D. Jo Heuschele, Kevin Smith, Peter Marchetto   +4 more
doaj   +1 more source

High throughput phenotyping of cross-sectional morphology to assess stalk lodging resistance

Plant Methods, 2022
Background Stalk lodging (mechanical failure of plant stems during windstorms) leads to global yield losses in cereal crops estimated to range from 5% to 25% annually.
Yusuf A. Oduntan, Christopher J. Stubbs, Daniel J. Robertson   +2 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Picturing the future of food

Plant Phenome Journal, 2021
High‐throughput phenotyping (HTP) has emerged as one of the most exciting and rapidly evolving spaces within plant science. The successful application of phenotyping technologies will facilitate increases in agricultural productivity.
Anna L. Casto, Haley Schuhl, Jose C. Tovar, Qi Wang, Rebecca S. Bart, Noah Fahlgren, Malia A. Gehan   +6 more
doaj   +1 more source

EuroPhenome: a repository for high-throughput mouse phenotyping data [PDF]

Nucleic Acids Research, 2009
The broad aim of biomedical science in the postgenomic era is to link genomic and phenotype information to allow deeper understanding of the processes leading from genomic changes to altered phenotype and disease. The EuroPhenome project (http://www.EuroPhenome.org) is a comprehensive resource for raw and annotated high-throughput phenotyping data ...
Morgan, Hugh, Beck, Tim, Blake, Andrew, Gates, Hilary, Adams, Niels, Debouzy, Guillaume, Leblanc, Sophie, Lengger, Christoph, Maier, Holger, Melvin, David, Meziane, Hamid, Richardson, Dave, Wells, Sara, White, Jacqui, Wood, Joe, De Angelis, Martin Hrabé, Brown, Steve D M, Hancock, John M., Mallon, Ann Marie, Neyses, Ludwig, Cartwright, Elizabeth; id_orcid 0000-0002-6836-7795, Prehar, Sukhpal, Zi, Min, Muller, Werner; id_orcid 0000-0002-1297-9725   +23 more
openaire   +5 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Integrating High-Throughput Phenotyping and Statistical Genomic Methods to Genetically Improve Longitudinal Traits in Crops

Frontiers in Plant Science, 2020
The rapid development of remote sensing in agronomic research allows the dynamic nature of longitudinal traits to be adequately described, which may enhance the genetic improvement of crop efficiency.
F. Moreira, H. R. Oliveira, J. Volenec, K. Rainey, L. Brito   +4 more
semanticscholar   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Can High Throughput Phenotyping Help Food Security in the Mediterranean Area?

Frontiers in Plant Science, 2019
According to the IPCC 2014 report the Mediterranean region will be affected by strong climatic changes, both in terms of average temperature and of precipitations regime.
Donatella Danzi, Nunzio Briglia, Angelo Petrozza, Stephan Summerer, Giovanni Povero, Alberto Stivaletta, Francesco Cellini, Domenico Pignone, Domenico Pignone, Domenico De Paola, Michela Janni, Michela Janni   +11 more
doaj   +1 more source