Results 101 to 110 of about 16,254,290 (323)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Can High Throughput Phenotyping Help Food Security in the Mediterranean Area?

Frontiers in Plant Science, 2019
According to the IPCC 2014 report the Mediterranean region will be affected by strong climatic changes, both in terms of average temperature and of precipitations regime.
Donatella Danzi, Nunzio Briglia, Angelo Petrozza, Stephan Summerer, Giovanni Povero, Alberto Stivaletta, Francesco Cellini, Domenico Pignone, Domenico Pignone, Domenico De Paola, Michela Janni, Michela Janni   +11 more
doaj   +1 more source

EuroPhenome: a repository for high-throughput mouse phenotyping data [PDF]

Nucleic Acids Research, 2009
The broad aim of biomedical science in the postgenomic era is to link genomic and phenotype information to allow deeper understanding of the processes leading from genomic changes to altered phenotype and disease. The EuroPhenome project (http://www.EuroPhenome.org) is a comprehensive resource for raw and annotated high-throughput phenotyping data ...
Morgan, Hugh, Beck, Tim, Blake, Andrew, Gates, Hilary, Adams, Niels, Debouzy, Guillaume, Leblanc, Sophie, Lengger, Christoph, Maier, Holger, Melvin, David, Meziane, Hamid, Richardson, Dave, Wells, Sara, White, Jacqui, Wood, Joe, De Angelis, Martin Hrabé, Brown, Steve D M, Hancock, John M., Mallon, Ann Marie, Neyses, Ludwig, Cartwright, Elizabeth, Prehar, Sukhpal, Zi, Min, Muller, Werner   +23 more
openaire   +5 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

In-field High Throughput Phenotyping and Cotton Plant Growth Analysis Using LiDAR

Frontiers in Plant Science, 2018
Plant breeding programs and a wide range of plant science applications would greatly benefit from the development of in-field high throughput phenotyping technologies.
Shangpeng Sun, Changying Li, Andrew H. Paterson, Andrew H. Paterson, Yu Jiang, Rui Xu, Jon S. Robertson, John L. Snider, Peng W. Chee   +8 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

High throughput phenotyping of cross-sectional morphology to assess stalk lodging resistance

Plant Methods, 2022
Background Stalk lodging (mechanical failure of plant stems during windstorms) leads to global yield losses in cereal crops estimated to range from 5% to 25% annually.
Yusuf A. Oduntan, Christopher J. Stubbs, Daniel J. Robertson   +2 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Assessing Wheat Traits by Spectral Reflectance: Do We Really Need to Focus on Predicted Trait-Values or Directly Identify the Elite Genotypes Group?

Frontiers in Plant Science, 2017
Phenotyping, via remote and proximal sensing techniques, of the agronomic and physiological traits associated with yield potential and drought adaptation could contribute to improvements in breeding programs. In the present study, 384 genotypes of wheat (
Miguel Garriga, Sebastián Romero-Bravo, Félix Estrada, Alejandro Escobar, Iván A. Matus, Alejandro del Pozo, Cesar A. Astudillo, Gustavo A. Lobos   +7 more
doaj   +1 more source