Results 81 to 90 of about 615,917 (326)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

High-throughput phenotyping for breeding targets - Current status and future directions of strawberry trait automation

, 2022
Automated image-based phenotyping has become widely accepted in crop phenotyping, particularly in cereal crops, yet few traits used by breeders in the strawberry industry have been automated.
Daniel James Sargent (10844461), Katherine James (17160739), Adam Whitehouse (17248276), Grzegorz Cielniak (17155543)   +3 more
core   +1 more source

High‐throughput phenotyping platforms for pulse crop biofortification

Plants, People, Planet
Societal Impact Statement Pulse crops, including dry pea, lentil, and chickpea, are rich sources of protein, low digestible carbohydrates, and micronutrients.
Amod Madurapperumage, M. Z. Naser, Lucas Boatwright, William Bridges, George Vandemark, Dil Thavarajah   +5 more
doaj   +1 more source

Proximal Active Optical Sensing Operational Improvement for Research Using the CropCircle ACS-470, Implications for Measurement of Normalized Difference Vegetation Index (NDVI)

Sensors, 2023
Active radiometric reflectance is useful to determine plant characteristics in field conditions. However, the physics of silicone diode-based sensing are temperature sensitive, where a change in temperature affects photoconductive resistance.
Matthew M. Conley, Alison L. Thompson, Reagan Hejl   +2 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

High Throughput Phenotyping in Plant Breeding

, 2022
An introduction to plant breeding and high throughput phenotyping. This lesson outlines the steps and goals of the plant breeding process and identifies areas that can be improved with high throughput phenotyping methods.
Mick, Catherine, Lee, Don, Sandall, Leah, Frels, Katherine Anna, Ge, Yufeng   +4 more
core  

High-throughput physical phenotyping of cell differentiation [PDF]

Microsystems & Nanoengineering, 2017
AbstractIn this report, we present multiparameter deformability cytometry (m-DC), in which we explore a large set of parameters describing the physical phenotypes of pluripotent cells and their derivatives. m-DC utilizes microfluidic inertial focusing and hydrodynamic stretching of single cells in conjunction with high-speed video recording to realize ...
Lin, Jonathan, Kim, Donghyuk, Tse, Henry T, Tseng, Peter, Peng, Lillian, Dhar, Manjima, Karumbayaram, Saravanan, Di Carlo, Dino   +7 more
openaire   +4 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Wellcounter: Automated high‐throughput phenotyping for aquatic microinvertebrates

Methods in Ecology and Evolution
Using phenotypic information extracted from digital images through automated computer vision analysis has become a promising avenue in ecological and evolutionary research.
Claus‐Peter Stelzer, Dominique Groffman   +1 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source