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High throughput screening for autophagy
2021Robotized high throughput screening allows for the assessment of autophagy in a large number of samples. Here, we describe a drug discovery platform for the phenotypic identification of novel autophagy inducers by means of automated cell biology workflows employing robotized cell culture, sample preparation and data acquisition.
Allan Sauvat +6 more
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Overview of High‐Throughput Screening
Current Protocols in Pharmacology, 2009AbstractHigh‐throughput screening (HTS) is a key process used in drug discovery to identify hits from compound libraries that may become leads for medicinal chemistry optimization. This updated overview discusses the utilization of compound libraries, compounds derived from combinatorial and parallel synthesis campaigns and natural product sources ...
Michael Entzeroth +2 more
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High-throughput screening for biocatalysts
Current Opinion in Biotechnology, 2001Recent progress in high-throughput enzyme assays includes new examples of fluorogenic and chromogenic substrates, fluorescence resonance energy transfer substrates, and applications of the pH and pM indicator methods. Recent developments of Horeau's pseudo-enantiomer derivatisation method to screen enantioselectivities in high-throughput have also been
Denis Wahler, Jean-Louis Reymond
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Automation of high throughputs screening
Computer Standards & Interfaces, 1998Advanced software is the key to successful laboratory automation. This article first describes a process known as high throughput screening used in the discovery of new drugs. The automation of high throughput screening is then outlined at three different scales of investment and resultant throughput.
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High-throughput screening: designer screens
Nature Methods, 2009Some researchers say an eighty-year-old statistical method can make setting up and analyzing high-throughput screens and large-scale experiments faster and more efficient. So why are more biologists not flocking to use this tool?
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High-Throughput Crystallization Screening
2014Protein structure determination by X-ray crystallography is dependent on obtaining a single protein crystal suitable for diffraction data collection. Due to this requirement, protein crystallization represents a key step in protein structure determination.
Tatiana Skarina +3 more
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Integration of virtual and high-throughput screening [PDF]
Nature Reviews Drug Discovery, 2002 High-throughput and virtual screening are important components of modern drug discovery research. Typically, these screening technologies are considered distinct approaches, as one is experimental and the other is theoretical in nature. However, given their similar tasks and goals, these approaches are much more complementary to each other than often ...
Jürgen Bajorath, Jürgen Bajorath
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High Throughput Screening Informatics
Combinatorial Chemistry & High Throughput Screening, 2008High throughput screening (HTS), an industrial effort to leverage developments in the areas of modern robotics, data analysis and control software, liquid handling devices, and sensitive detectors, has played a pivotal role in the drug discovery process, allowing researchers to efficiently screen millions of compounds to identify tractable small ...
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Screening for content—the evolution of high throughput [PDF]
Nature Biotechnology, 2003 Despite a poor return on investment thus far, innovations in high-throughput screening are still very much in demand.
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High‐Throughput Screening for Kinase Inhibitors
ChemBioChem, 2005AbstractFollowing G protein‐coupled receptors (GPCRs), protein kinases have become the second most important class of targets for drug discovery over the last 20 years. While only four kinase inhibitors have reached the market to date (Fasudil for rho‐dependent kinase, Rapamycin for TOR, Gleevec for BCR‐Abl, and Iressa for EGFR), many more are already ...
Oliver von Ahsen, Ulf Bömer
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