Results 91 to 100 of about 16,617,738 (336)
High-Throughput Screening for Boride Superconductors
Inorganic ChemistryA high-throughput screening using density functional calculations is performed to search for stable boride superconductors from the existing materials database. The workflow employs the fast frozen phonon method as the descriptor to evaluate the superconducting properties quickly. 23 stable candidates are identified from the screening.
Shiya Chen +6 more
openaire +3 more sources
Angewandte Chemie, 2019 Microfluidic droplet sorting enables the high throughput screening and selection of water-in-oil microreactors at speeds and volumes unparalleled by traditional well-plate approaches.
Daniel A Holland-Moritz +10 more
semanticscholar +1 more source
High-throughput screening for improved microbial cell factories, perspective and promise.
Current Opinion in Biotechnology, 2020 High-throughput screening is a critical part of any industrial strain engineering effort, helping ensure the lowest cost product is produced in the shortest amount of time.
M. Leavell +2 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
High-Throughput Screening For The Discovery Of Enzyme Inhibitors.
Journal of Medicinal Chemistry, 2020 Enzymes are common targets in high-throughput screening and related campaigns. An analysis of papers published between 1990 and 2018 showed that kinases were the most common enzymes investigated, fluorescence-based assays were the most common read-out ...
M. D. Lloyd
semanticscholar +1 more source
Assay for high-throughput screening of inhibitors of the ASC-PYD inflammasome core filament [PDF]
, 2018 The protein ASC is a central component of most inflammasome complexes, forming functional oligomeric filaments that activate large amounts of pro-caspase-1 for further IL-1β processing and the induction of Gasdermin D-dependent cell death.
Jonathan Vesin +15 more
core +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
High throughput screening for SARS-CoV-2 inhibitors targeting 5 helix bundle
SLAS DiscoverySARS-CoV-2 and other related viruses enter host cells via receptor recognition and membrane fusion. A crucial part of this is mediated by 5HB which is capable of binding to the viral spike heptad repeats (HR2) making 5HB a potential druggable target of ...
Emery Smith +6 more
doaj +1 more source
Bioactivity Profiling of Plant Biodiversity of Panama by High Throughput Screening
Natural Product Communications, 2019 We report relative bioactivities of extracts prepared from a large collection of plants from three national parks in Panama. Over 181 plants were collected, taxonomically identified and their detannified dichloromethane (DCM)-methanolic extracts were ...
Anuradha Roy +4 more
doaj +1 more source
Exploration of the nanomedicine-design space with high-throughput screening and machine learning
Nature Biomedical Engineering, 2019 Only a tiny fraction of the nanomedicine-design space has been explored, owing to the structural complexity of nanomedicines and the lack of relevant high-throughput synthesis and analysis methods.
Gokay Yamankurt +6 more
semanticscholar +1 more source