Results 91 to 100 of about 465,259 (306)

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

2018-10-22_RapidFire_BLAZE_ready_for_submission_SI – Supplemental material for RapidFire BLAZE-Mode Is Boosting ESI-MS Toward High-Throughput-Screening

, 2019
Supplemental material, 2018-10-22_RapidFire_BLAZE_ready_for_submission_SI for RapidFire BLAZE-Mode Is Boosting ESI-MS Toward High-Throughput-Screening by Tom Bretschneider, Can Ozbal, Markus Holstein, Martin Winter, Frank H.
Frank H. Buettner (6280724), Martin Winter (1579078), Markus Holstein (6280721), Andreas H. Luippold (5595206), Tom Bretschneider (1881343), Sven Thamm (670272), Can Ozbal (6280718), Daniel Bischoff (2717278)   +7 more
core   +1 more source

Structure-guided discovery of novel dUTPase inhibitors with anti-Nocardia activity by computational design

Journal of Enzyme Inhibition and Medicinal Chemistry
The zoonosis caused by Nocardia is increasing seriously. But commonly used antibiotic drugs often lead to resistance. N. seriolae dUTPase (NsdUTPase) plays a key role in the proliferation of Nocardia, and was regarded as a potent drug target.
Zhi-Zheng Wang, Jun Weng, Jing Qi, Xin-Xin Fu, Ban-Bin Xing, Yang Hu, Chun-Hsiang Huang, Chin-Yu Chen, Zigong Wei   +8 more
doaj   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Microarray technology as a universal tool for high-throughput analysis of biological systems

, 2006
Over the last years microarray technology has become one of the principal platform technologies for the high-throughput analysis of biological systems.
Jacob, A, Hoheisel, J D, Bartscherer, K, Sobek, J, Angenendt, P   +4 more
core   +1 more source

Using genetic tools and high-throughput screening to understand proteolysis in bacteria

, 2023
Schmitz, Karl R.All bacteria possess multiple ATP-dependent proteases that aid in the regulated destruction of cytosolic proteins. These enzymes regulate discrete cellular pathways and enforce protein quality control by degrading damaged or misfolded ...
Beardslee, Patrick Charles
core   +1 more source

Whole‑exome evolutionary profiling of osteosarcoma uncovers metastasis‑related driver mutations and generates an independently validated predictive classifier

Journal of Translational Medicine
Background Osteosarcoma is the most common primary malignant bone tumor, with high invasiveness and metastatic potential and a poor prognosis in patients with metastatic cancer. Despite the rapid advancements in genomics in recent years that provided new
Zhen Wang, Zhe Wang, Ruoyu Wang, Zumin Wang, Xiangyang Cao, Rui Chen, Zebing Ma, Shanshan Liang, Shuai Tao   +8 more
doaj   +1 more source

Novel PHL derivatives targeting quorum sensing: A strategy to combat Pseudomonas aeruginosa infections

Biofilm
Pseudomonas aeruginosa (P. aeruginosa) is a common pathogenic bacterium that is widely distributed and highly pathogenic. Its pathogenicity is closely related to the formation of biofilms and virulence factors.
Juanyan Liu, Yi Deng, Xinran Wang, Piao Luo, Shuaiwen Ding, Weizhong Zhang, Shahab Uddin, Hongyu Li, Yang Li   +8 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

High throughput screening

High Throughput Screening (HTS) is a drug discovery process that allows automated detection of large numbers of chemical and/or biological compounds for a specific biological target. It speed up target analysis, as large scale compound libraries can be quickly screened in a cost-effective way.
Nuwan Perera, Rangika S. Hikkaduwa Koralege   +1 more
  +5 more sources