Results 101 to 110 of about 465,259 (306)

High-throughput characterization of fluid properties to predict droplet ejection for three-dimensional inkjet printing formulations

, 2019
Inkjet printing has been used as an Additive Manufacturing (AM) method to fabricate three-dimensional (3D) structures. However, a lack of materials suitable for inkjet printing poses one of the key challenges that impedes industry from fully adopting ...
Xuesheng Chen, Roberts, Clive J., Ricky Wildman, Morgan R. Alexander, Zuoxin Zhou, Irvine, Derek, Richard Hague, Chen, Xuesheng, Wildman, Ricky, Derek Irvine, Laura Ruiz Cantu, Hague, Richard, Alexander, Morgan R., Clive J. Roberts, Ruiz Cantu, Laura, Tuck, Christopher, Christopher Tuck, Zhou, Zuoxin   +17 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Combinatorial synthesis and screening of chalcogenide materials for data storage

, 2005
For more than 15 years researchers at the Optoelectronics Research Centre at the University of Southampton have been developing novel compositions of chalcogenide glasses for a wide range of optical applications. Recently this expertise has been combined
Hayden, B., Simpson, R.E., Hewak, D.W., Purdy, G., Guerin, S.   +4 more
core  

Schisandrin B targets CDK4/6 to suppress proliferation and enhance radiosensitivity in nasopharyngeal carcinoma by inducing cell cycle arrest

Scientific Reports
Nasopharyngeal carcinoma (NPC) is notably prevalent in East and Southeast Asia, where despite advancements in radiotherapy leading to high control rates, challenges like radioresistance and collateral tissue damage remain significant. While Schisandrin B
Yanhua Fang, Xinhui Lv, Ge Li, Piao Wang, Lingling Zhang, Ruoyu Wang, Lingyun Jia, Shanshan Liang   +7 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Extracting fluorescent reporter time courses of cell lineages from high-throughput microscopy at low temporal resolution [PDF]

, 2011
The extraction of fluorescence time course data is a major bottleneck in high-throughput live-cell microscopy. Here we present an extendible framework based on the open-source image analysis software ImageJ, which aims in particular at analyzing the ...
Ott Sascha, Georgy Koentges, Mike J Downey, Jeziorska, DM, Tamai T. Katherine, Downey, Mike J., Downey Mike J., T. Katherine Tamai, Keith W, Bretschneider, T, Tamai, T Katherine, Downey, Mike J, Vance, KW, Ott, S, Mike J. Downey, Koentges, Georgy, Downey, MJ, Keith W Vance, Danuta M. Jeziorska, Bretschneider Till, Vance, Keith W., Jeziorska Danuta M., Till Bretschneider, Danuta M Jeziorska, Koentges Georgy, Sascha Ott, Vance Keith W., Koentges, G, T Katherine Tamai, Jeziorska, Danuta M, Bretschneider, Till, Jeziorska, Danuta M., Vance, Keith W, Ott, Sascha, Tamai, T. Katherine, Tamai, TK   +35 more
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce, Goknur Selen Kocak, José Verdú‐Díaz, Jorge Alonso‐Pérez, Kristl G. Claeys, Tanya Stojkovic, Gorka Fernández‐Eulate, Pascal Laforêt, Najoua Miladi, Filipe Di Pace, Cristiane Araujo Martins Moreno, Edmar Zanoteli, Conrad C. Weihl, Volker Straub, Ana Töpf, Jordi Díaz‐Manera, Sarcoglycan European Cohort Consortium, Adele D′Amico, Adolfo López de Munain, Alicia Alonso‐Jiménez, Ana Camacho‐Salas, Andrea Gangfuß, Andrés Nascimento, Anna Sarkozy, Anneke J. van der Kooi, Arturo Fraga‐Bau, Béla Melegh, Benedikt Schoser, Bjarne Udd, Blaz Koritnik, Carlos Ortez, Chiara Marini Bettolo, Chiara Panicucci, Claudia Weiss, Claudio Bruno, Claudio Semplicini, Cristina Dominguez‐González, Cristina Garrido, David Gómez‐Andrés, Edoardo Malfatti, Elena Pegoraro, Elke De Vos, Francina Munell, Gabriele Dekomien, Giacomo Pietro Comi, Giorgio Tasca, Isabelle Richard, Jan L. De Bleecker, Jana Haberlová, Jesper Helbo Storgaard, Johanna Palmio, John Vissing, Juan Carlos de Leon‐Hernández, Kinga Hadzsiev, Laura Costa‐Comellas, Lea Leonardis, Leroy ten Dam, Lidia González‐Quereda, Luca Bello, Luisa Politano, Manuela Santos, Marianne de Visser, Marie Rohlenová, Matteo Garibaldi, Michela Guglieri, Nicolas Deconinck, Nicoline Løkken, Omar Abdel‐Mannan, Pia Gallano, Roberto Fernández‐Torrón, Ulrike Schara‐Schmidt, Vincenzo Nigro, Vittoria Zangaro   +72 more
wiley   +1 more source

High throughput methodology for synthesis, screening, and optimization of solid state Lithium ion electrolytes

, 2011
A study of the lithium ion conductor Li3xLa2/3–xTiO3 solid solution and the surrounding composition space was carried out using a high throughput physical vapor deposition system.
Yokoishi, Shoji, Xiaojuan Lu, Denis Pasero, Duncan C. A. Smith, Thierry Le Gall, Shoji Yokoishi, Yada, Chihiro, Chihiro Yada, Andrew Weld, Christopher E. Lee, Le Gall, Thierry, Pasero, Denis, Lu, Xiaojuan, Mormiche, Claire, Beal, Mark, Mark S. Beal, Mehdi Mirsaneh, Mirsaneh, Mehdi, Weld, Andrew, Claire Mormiche, Hayden, Brian E., Brian E. Hayden, Lee, Christopher E., Smith, Duncan C.A.   +23 more
core   +1 more source

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source