Results 101 to 110 of about 16,617,738 (336)

Recent advances, opportunities, and challenges in high-throughput computational screening of MOFs for gas separations

Coordination chemistry reviews, 2020
In the last two decades, metal organic frameworks (MOFs) have gained significant attention as adsorbent and membrane materials for gas separations. Due to the large number and diversity of existing MOFs, identifying the best MOF materials for a gas ...
Hilal Daglar, Seda Keskin
semanticscholar   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

PKA plays a conserved role in regulating gene expression and metabolic adaptation by phosphorylating Rpd3/HDAC1

Nature Communications
Cells need to reprogram their metabolism to adapt to extracellular nutrient changes. The yeast histone acetyltransferase SAGA (Spt-Ada-Gcn5-acetyltransferase) has been reported to acetylate its subunit Ada3 and form homo-dimers to enhance its ability to ...
Wenjing Dai, Qi Yu, Rui Ma, Zhu Zheng, Lingling Hong, Yuqing Qi, Fei He, Min Wang, Feng Ge, Xilan Yu, Shanshan Li   +10 more
doaj   +1 more source

CRISPR–Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome

Nature Biotechnology, 2017
Large genome-mapping consortia and thousands of genome-wide association studies have identified non-protein-coding elements in the genome as having a central role in various biological processes.
Tyler S. Klann, Joshua B. Black, Malathi K Chellappan, Alexias Safi, Ling-Yun Song, Isaac B. Hilton, Gregory E. Crawford, Timothy E. Reddy, C. Gersbach   +8 more
semanticscholar   +1 more source

An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes [PDF]

, 2018
Parasitic nematodes infect hundreds of millions of people and farmed livestock. Further, plant parasitic nematodes result in major crop damage. The pipeline of therapeutic compounds is limited and parasite resistance to the existing anthelmintic ...
Lomas, D.A., Matthews, J.B., Else, K.J., Morrison, A.A., Brown, A.E., Forman, R., Buckingham, S.D., Wynne, G.M., Partridge, F.A., Sattelle, D.B., Willis, N.J., Russell, A.J.   +11 more
core   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

3D bioprinting for high-throughput screening: Drug screening, disease modeling, and precision medicine applications

Applied Physics Reviews, 2019
High-throughput technologies have become essential in many fields of pharmaceutical and biological development and production. Such technologies were initially developed with compatibility with liquid handling-based cell culture techniques to produce ...
Andrea Mazzocchi, S. Soker, A. Skardal
semanticscholar   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Complementary approaches to target human respiratory syncytial virus using small molecule ligands [PDF]

, 2012
In the current project, situated at the interface of chemistry and virology, complementary drug discovery approaches (high-throughput screening and structurebased drug design) have been exploited in order to discover novel small molecule inhibitors of ...
Lardeau, Charles-Hugues Claude Jean
core   +4 more sources

A comprehensive review of Schisandrin B’s preclinical antitumor activity and mechanistic insights from network pharmacology

Frontiers in Pharmacology
As an active constituent in the extract of dried fruits of Schisandra chinensis, Schisandrin B exhibits diverse pharmacological effects, including liver protection, anti-inflammatory and anti-oxidant. Numerous studies have demonstrated that Schisandrin B
Yanhua Fang, Yanhua Fang, Juan Pan, Piao Wang, Piao Wang, Ruoyu Wang, Shanshan Liang   +6 more
doaj   +1 more source