Schisandrin B Inhibits Osteoclastogenesis and Protects Against Ovariectomy-Induced Bone Loss [PDF]
Frontiers in Pharmacology, 2020 Osteoporosis is a systemic skeletal disease which is highly prevalent worldwide and considered to be associated with excessive bone resorption mediated by osteoclast.
Jia Wang +9 more
doaj +5 more sources
Albendazole-Schisandrin B Co-Therapy on Angiostrongylus cantonensis-Induced Meningoencephalitis in Mice [PDF]
Biomolecules, 2020 Currently, Angiostrongylus cantonensis infections are predominantly treated with albendazole. However, the use of albendazole can provoke certain neurological symptoms as a result of the immune response triggered by the dead worms.
Ho Yin Pekkle Lam +3 more
doaj +5 more sources
Schisandrin B Attenuates Hepatic Stellate Cell Activation and Promotes Apoptosis to Protect against Liver Fibrosis [PDF]
Molecules, 2021 The activation of hepatic stellate cells (HSC) plays a key role in the progression of hepatic fibrosis, it is essential to remove activated HSC through apoptosis to reverse hepatic fibrosis.
Zhiman Li +5 more
doaj +2 more sources
Schisandrin B Attenuates Airway Inflammation by Regulating the NF-κB/Nrf2 Signaling Pathway in Mouse Models of Asthma [PDF]
Journal of Immunology Research, 2021 Background. Asthma is a complex inflammatory disorder that plagues a large number of people. Schisandrin B is an active ingredient of the traditional Chinese herbal medicine Schisandra with various proven physiological activities such as anti ...
Yaqin Chen +6 more
doaj +2 more sources
Supplementation of Schisandrin B in Semen Extender Improves Quality and Oxidation Resistance of Boar Spermatozoa Stored at 4 °C [PDF]
Animals, 2023 During cold storage, boar spermatozoa undergo oxidative stress, which can impair sperm function and fertilizing capacity. The objective of the present study was to assess the effects of Schisandrin B (Sch B) in semen extenders on the quality of boar ...
Yunfa Xie +9 more
doaj +2 more sources
Investigating the therapeutic mechanism of Bufei Decoction in COPD: Schisandrin B targets the TLR4/NF-κB/JAK-STAT signaling pathway [PDF]
HereditasObjective Evaluate Bufei Decoction effects on chronic obstructive pulmonary disease (COPD) and elucidate Schisandrin B (Sch B) mechanism via TLR4 pathway. Methods COPD was induced in rats using LPS/cigarette smoke. Effects of low, medium, high-dose Bufei
Xiaoyan Li, Bin Lv, Shumei Wang
doaj +2 more sources
Schisandrin B promotes senescence of activated hepatic stellate cell via NCOA4-mediated ferritinophagy [PDF]
Pharmaceutical Biology, 2023 Context Schisandrin B (Sch B), an active ingredient from Schisandrae chinensis (Turcz.) Baill. (Schisandraceae) Fructus, possesses diverse pharmacological activities including antitumor, anti-inflammation, and hepatoprotection.Objective To explore the ...
Mingyue Ma +7 more
doaj +2 more sources
Schisandrin B Attenuates Diabetic Cardiomyopathy by Targeting MyD88 and Inhibiting MyD88‐Dependent Inflammation [PDF]
Advanced Science, 2022 Diabetes manifests as chronic inflammation and leads to the development diabetic cardiomyopathy (DCM). Targeting key proteins in inflammatory signaling may provide new therapy for DCM.
Wu Luo +9 more
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A comprehensive review of Schisandrin B’s preclinical antitumor activity and mechanistic insights from network pharmacology [PDF]
Frontiers in PharmacologyAs an active constituent in the extract of dried fruits of Schisandra chinensis, Schisandrin B exhibits diverse pharmacological effects, including liver protection, anti-inflammatory and anti-oxidant. Numerous studies have demonstrated that Schisandrin B
Yanhua Fang +6 more
doaj +3 more sources
Schisandrin B exerts anti-colorectal cancer effect through CXCL2/ERK/DUSP11 signaling pathway [PDF]
Cancer Cell InternationalBackground Schisandrin B (Sch B) is an active component in Schisandra chinensis exerting anti-cancer effect, but the mechanism is obscure. This study was designed to explore the mechanism of Sch B against colorectal cancer (CRC).
Jianguo Sun +10 more
doaj +2 more sources