Results 21 to 30 of about 12,357,672 (189)
A comprehensive review of Schisandrin B’s preclinical antitumor activity and mechanistic insights from network pharmacology [PDF]
Frontiers in PharmacologyAs an active constituent in the extract of dried fruits of Schisandra chinensis, Schisandrin B exhibits diverse pharmacological effects, including liver protection, anti-inflammatory and anti-oxidant. Numerous studies have demonstrated that Schisandrin B
Yanhua Fang +6 more
doaj +2 more sources
Production of Schisandrin A and Schisandrin B from Callus and Suspension Cell Cultures of [PDF]
Natural Product Communications, 2017 For establishing the fermentation system of synthetic schizandrin A and schizandrin B, culture conditions of the Schisandra chinensis callus and the suspension cell were studied in this paper.
Yong-Qiang Zhou +2 more
doaj +2 more sources
Differential Effect of Schisandrin B Stereoisomers on ATR-Mediated DNA Damage Checkpoint Signaling
Journal of Pharmacological Sciences, 2013 We have previously reported that schisandrin B (SchB) is a specific inhibitor of ATR (ataxia telangiectasia and Rad-3-related) protein kinase. Since SchB consists of a mixture of its diastereomers gomisin N (GN) and γ-schisandrin (γ-Sch), the inhibitory ...
Naoto Tatewaki +6 more
doaj +2 more sources
Schisandrin B regulates lipid metabolism in subcutaneous adipocytes
Scientific Reports, 2017 AbstractSubcutaneous adipocytes in obese subjects have a lower sensitivity to catecholamine-induced lipolysis and a higher sensitivity to insulin anti-lipolytic effects compared to adipocytes in other adipose depots. Therefore, increasing lipolysis in subcutaneous adipocytes coupled with enhanced fatty acid oxidation may be an anti-obesity strategy ...
Kwan, Hiu Yee +10 more
openaire +3 more sources
The Effect of Schisandrin B on the Development of Multiple Sclerosis [PDF]
Proceedings, 2019 Multiple Sclerosis (MS) is a chronic inflammatory, demyelinating neurodegenerative disease targeting the central nervous system. The pathogenesis of MS is a process of innate and adaptive immune system components.
Mustafa Cakir +3 more
doaj +4 more sources
, 2007 Schisandrin B is an extract from a Chinese medicine, which is well known of treating various cardiovascular diseases and many other conditions. The invention reveals the method of preparation of Schisandrin B, and how to use it in prevention and/or ...
Ko, Robert K.M.
openaire +6 more sources
International Journal of Toxicology, 2011 The cost of dexrazoxane, a drug used to provide protection from doxorubicin-induced cardiotoxicity, limits its use in low-income countries. We aimed to see whether schisandrin B, an inexpensive drug, could provide protection equivalent to that provided by dexrazoxane.
Feifei, Che, Yu, Liu, Caigang, Xu
openaire +3 more sources
Separation and Purification of Schisandrin B from Fructus Schisandrae
Industrial & Engineering Chemistry Research, 2008 Schisandrin B (Sch B) is the most abundant and biologically active dibenzocyclooctadiene lignan present in Fructus Schisandrae (FS). It is a highly desirable ingredient for a dietary supplement. While Sch B has been isolated from FS in the laboratory, the experimental procedure was usually lengthy and the yield was relatively low. The objective of this
Luk, Ka Fai SENG +2 more
openaire +3 more sources
Schisandrin B as a Hormetic Agent for Preventing Age-Related Neurodegenerative Diseases [PDF]
Oxidative Medicine and Cellular Longevity, 2012 Oxidative stress and mitochondrial dysfunction have been implicated in the pathogenesis of neurodegenerative diseases, with the latter preceding the appearance of clinical symptoms. The energy failure resulting from mitochondrial dysfunction further impedes brain function, which demands large amounts of energy.
Lam, Yeung LIFS, Ko, Robert K.M.
openaire +4 more sources
Drug Design, Development and Therapy, 2018 Jibo Han,* Xiaowen Shi,* Zhanxiong Zheng, Bin Zhang, Fengjie Shi, Liqin Jiang, Jianjiang Xu Department of Cardiology, Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang 314000, China *These authors contributed equally to this work ...
Han J +6 more
doaj +1 more source