Results 31 to 40 of about 12,357,672 (189)

Schisandrin B promotes hepatic differentiation from human umbilical cord mesenchymal stem cells [PDF]

open access: yesiScience
Summary: Human umbilical cord mesenchymal stem cells (UC-MSCs)-derived hepatocyte-like cells (HLCs) have shown great promise in the treatment of liver diseases.
Meixian Jin   +14 more
doaj   +2 more sources

Schisandrin B attenuates CCl4-induced liver fibrosis in rats by regulation of Nrf2-ARE and TGF-β/Smad signaling pathways

open access: yesDrug Design, Development and Therapy, 2017
Qingshan Chen,1,* Hai Zhang,2,* Yan Cao,3 Ying Li,1 Sen Sun,1 Junping Zhang,4 Guoqing Zhang1 1Department of Pharmacy, Shanghai Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China, 2Department of Pharmacy, Shanghai ...
Chen QS   +6 more
doaj   +1 more source

In Silico Analysis, Anticonvulsant Activity, and Toxicity Evaluation of Schisandrin B in Zebrafish Larvae and Mice. [PDF]

open access: yesInt J Mol Sci, 2023
The aim of this study is to evaluate the anticonvulsant potential of schisandrin B, a main ingredient of Schisandra chinensis extracts. Schisandrin B showed anticonvulsant activity in the zebrafish larva pentylenetetrazole acute seizure assay but did not
Nieoczym D   +7 more
europepmc   +2 more sources

Schisandrin B elicits the Keap1-Nrf2 defense system via carbene reactive metabolite which is less harmful to mice liver

open access: yesDrug Design, Development and Therapy, 2018
Shan Feng,* Bingxun Qiu,* Li Zou, Ke Liu, Xiaoyu Xu, Huifeng Zhu College of Pharmaceutical Sciences and Chinese Medicine, Southwest University, Beibei, Chongqing 400715, China *These authors contributed equally to this work Background: Schisandrin B ...
Feng S, Qiu B, Zou L, Liu K, Xu X, Zhu H
doaj   +1 more source

Schisandrin B for Treatment of Male Infertility [PDF]

open access: yesSSRN Electronic Journal, 2020
Abstract The decline of male fertility and its consequences on human populations are important public-health issues. However, there are limited choices for treatment of male infertility. In an attempt to identify a compound that could promote male fertility, we identified and characterized a library of small molecules
Di-Xin Zou   +13 more
openaire   +2 more sources

The influence of dibenzocyclooctadiene lignans on macrophage glutathione and lipid metabolism associated with Chlamydia pneumoniae-induced foam cell formation

open access: yesAdvances in Redox Research, 2021
Triggered by changes in macrophage redox status and lipid metabolism, foam cells represent a hallmark of atherosclerosis. Induction of macrophage foam cell formation by Chlamydia pneumoniae, a gram-negative human pathogen, has been established in various
Maarit Kortesoja   +2 more
doaj   +1 more source

A Comprehensive Review on Schisandrin B and Its Biological Properties [PDF]

open access: yesOxidative Medicine and Cellular Longevity, 2020
Nature is a vast source of bioactive molecules and has provided an active and efficient reservoir for drug discovery. Among natural compounds, one of the most promising is Schisandrin B (Sch B), isolated from Schisandra chinensis, which was documented to possess diversified pharmacokinetic propriety, among them antioxidant, anti-inflammation ...
M. I. Nasser   +5 more
openaire   +3 more sources

Prevention of the Pro-Aggressive Effects of Ethanol-Intoxicated Mice by Schisandrin B. [PDF]

open access: yesNutrients, 2023
Excessive alcohol consumption can lead to serious health complications, with liver and neurological complications being the most important. In Western nations, alcoholic liver disease accounts for 50% of mortality from end-stage liver disease and is the second most common cause of liver transplants.
Lam HYP, Liang TR, Peng SY.
europepmc   +3 more sources

Schisandrin B Inhibits Osteoclastogenesis and Protects Against Ovariectomy-Induced Bone Loss

open access: yesFrontiers in Pharmacology, 2020
Osteoporosis is a systemic skeletal disease which is highly prevalent worldwide and considered to be associated with excessive bone resorption mediated by osteoclast.
Jia Wang   +9 more
doaj   +1 more source

Screening of Botanical Drugs against SARS-CoV-2 Entry Reveals Novel Therapeutic Agents to Treat COVID-19

open access: yesViruses, 2022
An escalating pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has severely impacted global health. There is a severe lack of specific treatment options for diseases caused by SARS-CoV-2.
Junyuan Cao   +10 more
doaj   +1 more source

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