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High-throughput screening for biocatalysts
Current Opinion in Biotechnology, 2001Recent progress in high-throughput enzyme assays includes new examples of fluorogenic and chromogenic substrates, fluorescence resonance energy transfer substrates, and applications of the pH and pM indicator methods. Recent developments of Horeau's pseudo-enantiomer derivatisation method to screen enantioselectivities in high-throughput have also been
Wahler D, Reymond JL
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Overview of High‐Throughput Screening
Current Protocols in Pharmacology, 2009AbstractHigh‐throughput screening (HTS) is a key process used in drug discovery to identify hits from compound libraries that may become leads for medicinal chemistry optimization. This updated overview discusses the utilization of compound libraries, compounds derived from combinatorial and parallel synthesis campaigns and natural product sources ...
Michael, Entzeroth +2 more
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High-throughput screening: designer screens
Nature Methods, 2009Some researchers say an eighty-year-old statistical method can make setting up and analyzing high-throughput screens and large-scale experiments faster and more efficient. So why are more biologists not flocking to use this tool?
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Automation of high throughputs screening
Computer Standards & Interfaces, 1998Advanced software is the key to successful laboratory automation. This article first describes a process known as high throughput screening used in the discovery of new drugs. The automation of high throughput screening is then outlined at three different scales of investment and resultant throughput.
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High Throughput Screening Informatics
Combinatorial Chemistry & High Throughput Screening, 2008High throughput screening (HTS), an industrial effort to leverage developments in the areas of modern robotics, data analysis and control software, liquid handling devices, and sensitive detectors, has played a pivotal role in the drug discovery process, allowing researchers to efficiently screen millions of compounds to identify tractable small ...
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High-Throughput Crystallization Screening
2014Protein structure determination by X-ray crystallography is dependent on obtaining a single protein crystal suitable for diffraction data collection. Due to this requirement, protein crystallization represents a key step in protein structure determination.
Tatiana, Skarina +3 more
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High-throughput screening technologies
2003In the past 5 years the world of high-throughput screening (HTS), which targets lead discovery for both pharmaceutical and agrochemical applications, is in a highly rapid developmental stage. Today, restructuring the drug discovery programs to develop highest performance is a key issue of pharmaceutical companies.
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2014
Ion channels are a class of proteins that are attractive human, animal, and crop health targets. Ion channels can be considered high-gain (physiologically speaking), high-reward (therapeutic benefit) and high technology (difficult assay development) drug targets.
Alexander Böcker +2 more
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Ion channels are a class of proteins that are attractive human, animal, and crop health targets. Ion channels can be considered high-gain (physiologically speaking), high-reward (therapeutic benefit) and high technology (difficult assay development) drug targets.
Alexander Böcker +2 more
openaire +1 more source