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High‐Throughput Screening for Phase‐Change Memory Materials
Advanced Functional Materials, 2021Phase change memory (PCM) is an emerging non‐volatile data storage technology concerned by the semiconductor industry. To improve the performances, previous efforts have mainly focused on partially replacing or doping elements in the flagship Ge‐Sb‐Te ...
Yu-ting Liu +7 more
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Overview of High‐Throughput Screening
Current Protocols in Pharmacology, 2009AbstractHigh‐throughput screening (HTS) is a key process used in drug discovery to identify hits from compound libraries that may become leads for medicinal chemistry optimization. This updated overview discusses the utilization of compound libraries, compounds derived from combinatorial and parallel synthesis campaigns and natural product sources ...
Michael, Entzeroth +2 more
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High-Throughput Screening: today's biochemical and cell-based approaches.
Drug Discovery Today, 2020High-throughput screening (HTS) provides starting chemical matter in the adventure of developing a new drug. In this review, we survey several HTS methods used today for hit identification, organized in two main flavors: biochemical and cell-based assays.
Vincent Blay +3 more
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High-throughput screening for biocatalysts
Current Opinion in Biotechnology, 2001Recent progress in high-throughput enzyme assays includes new examples of fluorogenic and chromogenic substrates, fluorescence resonance energy transfer substrates, and applications of the pH and pM indicator methods. Recent developments of Horeau's pseudo-enantiomer derivatisation method to screen enantioselectivities in high-throughput have also been
Wahler D, Reymond JL
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High-Throughput Screening Technology in Industrial Biotechnology.
Trends in Biotechnology, 2020Based on the development of automatic devices and rapid assay methods, various high-throughput screening (HTS) strategies have been established for improving the performance of industrial microorganisms.
Wei-Zhu Zeng +4 more
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High-throughput screening: designer screens
Nature Methods, 2009Some researchers say an eighty-year-old statistical method can make setting up and analyzing high-throughput screens and large-scale experiments faster and more efficient. So why are more biologists not flocking to use this tool?
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Therapeutic Drugs Targeting 2019-nCoV Main Protease by High-Throughput Screening
bioRxiv, 20202019 Novel Coronavirus (2019-nCoV) is a virus identified as the cause of the outbreak of pneumonia first detected in Wuhan, China. Investigations on the transmissibility, severity, and other features associated with this virus are ongoing.
Yan Li +8 more
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Automation of high throughputs screening
Computer Standards & Interfaces, 1998Advanced software is the key to successful laboratory automation. This article first describes a process known as high throughput screening used in the discovery of new drugs. The automation of high throughput screening is then outlined at three different scales of investment and resultant throughput.
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High-Throughput Crystallization Screening
2014Protein structure determination by X-ray crystallography is dependent on obtaining a single protein crystal suitable for diffraction data collection. Due to this requirement, protein crystallization represents a key step in protein structure determination.
Tatiana, Skarina +3 more
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High Throughput Screening Informatics
Combinatorial Chemistry & High Throughput Screening, 2008High throughput screening (HTS), an industrial effort to leverage developments in the areas of modern robotics, data analysis and control software, liquid handling devices, and sensitive detectors, has played a pivotal role in the drug discovery process, allowing researchers to efficiently screen millions of compounds to identify tractable small ...
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