Results 71 to 80 of about 1,236,846 (314)

The Expression and Prognostic Value of Cancer Stem Cell Markers, NRF2, and Its Target Genes in TAE/TACE-Treated Hepatocellular Carcinoma

Medicina, 2022
Background and Objectives: Activation of NRF2, a key transcription factor of cytoprotectant against oxidative stress, and its target genes are associated with aggressive tumor progression, metastasis and poor survival.
Duurenjargal Tseeleesuren, Hui-Hua Hsiao, Rajni Kant, Yu-Chuen Huang, Hung-Pin Tu, Chih-Chung Lai, Shiu-Feng Huang, Chia-Hung Yen   +7 more
doaj   +1 more source

Convolutional Neural Network of Atomic Surface structures to Predict Binding Energies For High-throughput Screening of Catalysts.

Journal of Physical Chemistry Letters, 2019
High-throughput screening of catalysts can be performed using density functional theory calculations to predict catalytic properties, often correlated with adsorbate binding energies. However, more complete investigations would require an order of 2 more
S. Back, Junwoong Yoon, Nianhan Tian, Wen Zhong, Kevin Tran, Zachary W. Ulissi   +5 more
semanticscholar   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Effects of novel microecologics combined with traditional Chinese medicine and probiotics on growth performance and health of broilers

Poultry Science, 2022
: In this study, we prepared a kind of novel microecologics, namely Chinese medicine–probiotic compound microecological preparation (CPCMP), which is composed of 5 traditional Chinese medicine herbs (Galla Chinensis, Andrographis paniculata, Arctii ...
Jin Gao, Rui Wang, Jingxuan Liu, Wenling Wang, Yong Chen, Wentao Cai   +5 more
doaj   +1 more source

Robot-Based High-Throughput Screening of Antisolvents for Lead Halide Perovskites

, 2020
Summary Solution-based processing of photovoltaic materials has important advantages, including lower overall costs and easier upscaling of fabrication, where the solvents play an essential role.
Ening Gu, Xiaofeng Tang, S. Langner, P. Duchstein, Yicheng Zhao, Ievgen Levchuk, Violetta Kalancha, T. Stubhan, J. Hauch, H. Egelhaaf, D. Zahn, A. Osvet, C. Brabec   +12 more
semanticscholar   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

High-throughput in vivo vertebrate screening [PDF]

, 2010
We demonstrate a high-throughput platform for cellular-resolution in vivo chemical and genetic screens on zebrafish larvae. The system automatically loads zebrafish from reservoirs or multiwell plates, and positions and rotates them for high-speed ...
A Funfak, AL Rubinstein, Bryan Kyo Koo, C Fricke, Carlos Pardo-Martin, CB Rohde, CE Buckley, Cody L Gilleland, DH Bhatt, GJ Lieschke, J Gehrig, J Karlsson, JD Steinmeyer, JT Shin, LI Zon, Mehmet Fatih Yanik, MF Yanik, P McGrath, Steven C Wasserman, T Xiao, Tsung-Yao Chang   +20 more
core   +2 more sources

A new vulnerability to BET inhibition due to enhanced autophagy in BRCA2 deficient pancreatic cancer

Cell Death and Disease, 2023
Pancreatic cancer is one of the deadliest diseases in human malignancies. Among total pancreatic cancer patients, ~10% of patients are categorized as familial pancreatic cancer (FPC) patients, carrying germline mutations of the genes involved in DNA ...
EunJung Lee, Suyakarn Archasappawat, Keely Ji, Jocelyn Pena, Virneliz Fernandez-Vega, Ritika Gangaraju, Nitin Sai Beesabathuni, Martin Jean Kim, Qi Tian, Priya S. Shah, Louis Scampavia, Timothy P. Spicer, Chang-Il Hwang   +12 more
doaj   +1 more source

Protective Effect of Arbidol Against Pulmonary Fibrosis and Sepsis in Mice

Frontiers in Pharmacology, 2021
From the perspective of epidemiology, viral immunology and current clinical research, pulmonary fibrosis may become one of the complications of patients with Coronavirus Disease 2019 (COVID-19).
Hailong Li, Hailong Li, Rui Liu, Rui Liu, Ruotong Zhang, Ruotong Zhang, Shanshan Zhang, Yiying Wei, Yiying Wei, Liang Zhang, Honggang Zhou, Honggang Zhou, Cheng Yang, Cheng Yang   +13 more
doaj   +1 more source

High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping.

Cell Stem Cell, 2018
Organoids derived from human pluripotent stem cells are a potentially powerful tool for high-throughput screening (HTS), but the complexity of organoid cultures poses a significant challenge for miniaturization and automation.
Stefan M Czerniecki, N. Cruz, J. Harder, R. Menon, James E. Annis, E. Otto, Ramila E. Gulieva, Laura Islas, Yong Kyun Kim, L. Tran, T. Martins, J. Pippin, Hongxia Fu, M. Kretzler, S. Shankland, J. Himmelfarb, R. Moon, N. Paragas, Benjamin S. Freedman   +18 more
semanticscholar   +1 more source