Organoids in pediatric cancer research
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
A 35-year comparison of children labelled as gifted, unlabelled as gifted and average-ability
http://dx.doi.org/10.5902/1984686X14273Why are some children seen as gifted while others of identical ability are not? To find out why and what the consequences might be, in 1974 I began in England with 70 children labelled as gifted.
Joan Freeman
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Extracurricular enrichment workshops for high ability students [PDF]
The aim of this article is to analyze and explain attention to diversity measures for high ability (gifted and talented) students. The model, developed in the Spanish region of Murcia, is based on cognitive psychology and aims to encourage thinking ...
Ángela Rojo +5 more
doaj
World Perception and High Intellectual Ability: A Comparative Study
From a neuroconstructivist point of view and a developmental model of high intellectual abilities (HIA), the aim of this study is to understand the world perception of high intellectual children, which results from their cognitive complexity and other ...
Mª Luz Urraca-Martínez +2 more
doaj +1 more source
Attitudes about gifted education among Irish educators
In 2018, gifted education has not been formalized in the Irish education system. To better advocate for the needs of high-ability students in Ireland, a survey was distributed to educators across the country (N = 837) regarding gifted education.
Cross, Jennifer Riedl +2 more
core +1 more source
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
The Use Of Cabri 3D Software As Virtual Manipulation Tool In 3-Dimension Geometry Learning To Improve Junior High School Students’ Spatial Ability [PDF]
This study is aimed to know students’ spatial ability who work under 3-dimension learning use Cabri 3D software at Junior High School in Bandung.
Toto , Subroto
core
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source

