Results 11 to 20 of about 15,885,779 (299)

Advancing high-altitude medicine: a model for the future [PDF]

Signal Transduction and Targeted Therapy
With rising global high-altitude travel, occupational exposure, and permanent habitation, the health burden of high-altitude-specific diseases and high-altitude-related diseases has become increasingly prominent, highlighting an urgent need for in-depth ...
Wenjin Sun, Xuan Zhang, Ling Chen, Lei Chen, Cheng Deng, Shizheng Wu, Fengming Luo   +6 more
doaj   +2 more sources

G Protein‐Coupled Receptor in High‐Altitude Diseases: Mechanistic Insights and Therapeutic Opportunities [PDF]

MedComm
High‐altitude diseases (HADs) encompass a spectrum of acute and chronic disorders—including acute mountain sickness, high‐altitude cerebral edema, high‐altitude pulmonary edema, high‐altitude polycythemia, high‐altitude pulmonary hypertension, and high ...
Qing Zhao, Changliang Liu, Lu Dai, Kun Zheng, Kun Liang, Chuanling Pan, Lianhua Liu, Ling Chen, Xuefei He, Hui Yan, Lei Chen, Huaping Zheng, Cheng Deng, Fengming Luo   +13 more
doaj   +2 more sources

The mudflow dynamics of the river Gerkhozhan-Su in the section of the mudflow tray and mudslides protection of the city of Tyrnyauz (Central Caucasus) [PDF]

E3S Web of Conferences, 2020
Based on the data of route inspection and video surveillance of the mudslides of the river Gerkhozhan-Su have been determined the features of the mudslides dynamics in the section of the mudflow tray.
Dokukin Mikhail, Bekkiev Mukhtar, Kalov Ruslan, Hadjiev Mukhtar   +3 more
doaj   +1 more source

DL-3-n-butylphthalide improved physical and learning and memory performance of rodents exposed to acute and chronic hypobaric hypoxia

Military Medical Research, 2021
Background Studies have revealed the protective effect of DL-3-n-butylphthalide (NBP) against diseases associated with ischemic hypoxia. However, the role of NBP in animals with hypobaric hypoxia has not been elucidated.
Gang Xu, Yi-Kun Shi, Bin-Da Sun, Lu Liu, Guo-Ji E., Shu He, Jian-Yang Zhang, Bao Liu, Qiu Hu, Jian Chen, Yu-Qi Gao, Er-Long Zhang   +11 more
doaj   +1 more source

Hypoxia exacerbates intestinal injury and inflammatory response mediated by myeloperoxidase during Salmonella Typhimurium infection in mice

Gut Pathogens, 2023
Background High-altitude exposure can cause oxidative stress damage in the intestine, which leads to increased intestinal permeability and bacterial translocation, resulting in local and systemic inflammation. Control of infection is critically dependent
Qinfang Zhu, Ying Han, Xiaozhou Wang, Ruhan Jia, Jingxuan Zhang, Meiheng Liu, Wei Zhang   +6 more
doaj   +1 more source

Morphometric, haematological and physio-biochemical characterization of Bactrian (Camelus bactrianus) camel at high altitude

BMC Veterinary Research, 2020
Background Biochemical and haematological parameters have not been determined in Bactrian camels kept at high altitude. Therefore, this study was undertaken to characterise different physiological, haematological, biochemical, and morphometric parameters
Dolker Lamo, Geeta Gahlawat, Sunil Kumar, Vijay K. Bharti, Puneet Ranjan, Deepak Kumar, Om Prakash Chaurasia   +6 more
doaj   +1 more source

MN•CS•IO System: Cross-Species Study for HBB Function in High-Altitude Hypoxia Adaptation. [PDF]

Adv Sci (Weinh)
We developed an integrative mesh‐nanorod sorting, chitosan nanoparticle delivery, and intraosseous injection (MN•CS•IO) system to investigate HBB in high‐altitude hypoxia adaptation. Transplanting Tibetan animals' HBB‐modified Lin‐ cells into mice achieved 95.59% transfection efficiency and 8.15% HBB expression. High‐altitude HBB recipients upregulated
Hui W, Mao L, Li B, Kang H, Tang Z, Chen S, Yang H, Qiao Y, Ding H, Wang Y, Li M, Hu J, Ye S, Wang X, Xu X, Wang Y, Wuren T, Ban Q, Zhang B.   +18 more
europepmc   +2 more sources

Inflammation and immunity in the pathogenesis of hypoxic pulmonary hypertension

Frontiers in Immunology, 2023
Hypoxic pulmonary hypertension (HPH) is a complicated vascular disorder characterized by diverse mechanisms that lead to elevated blood pressure in pulmonary circulation.
Yi Ye, Yi Ye, Yi Ye, Yi Ye, Qiying Xu, Qiying Xu, Qiying Xu, Qiying Xu, Tana Wuren, Tana Wuren, Tana Wuren, Tana Wuren   +11 more
doaj   +1 more source

Excessive gas exchange impairment during exercise in a subject with a history of bronchopulmonary dysplasia and high altitude pulmonary edema [PDF]

, 2007
A 27-year-old male subject (V(O2 max)), 92% predicted) with a history of bronchopulmonary dysplasia (BPD) and a clinically documented case of high altitude pulmonary edema (HAPE) was examined at rest and during exercise.
Lovering, AT, Haverkamp, HC, Hokanson, JS, Eldridge, MW, Andrew T. Lovering, Lee M. Romer, John S. Hokanson, Romer, LM, Marlowe W. Eldridge, Hans C. Haverkamp   +9 more
core   +1 more source

Excessive Iron Availability Caused by Disorders of Interleukin-10 and Interleukin-22 Contributes to High Altitude Polycythemia

Frontiers in Physiology, 2018
Background: Because the pathogenesis of high altitude polycythemia (HAPC) is unclear, the aim of the present study was to explore whether abnormal iron metabolism is involved in the pathogenesis of HAPC and the possible cause.Methods: We examined the ...
Yun-Sheng Liu, Yun-Sheng Liu, Yun-Sheng Liu, Yun-Sheng Liu, He Huang, He Huang, He Huang, Si-Min Zhou, Si-Min Zhou, Si-Min Zhou, Huai-jun Tian, Huai-jun Tian, Huai-jun Tian, Peng Li, Peng Li, Peng Li   +15 more
doaj   +1 more source