Results 61 to 70 of about 3,929,652 (265)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Diamond Detectors for Timing Measurements in High Energy Physics

Frontiers of Physics, 2020
Timing detectors are a well-established part of High Energy Physics experimental instrumentation. The choice of sensors with fast (less than 10 ns) and precise (better than 100 ps) signals, together with radiation resistance considerations, are an ...
E. Bossini, N. Minafra
semanticscholar   +1 more source

Machine Learning in High Energy Physics Community White Paper [PDF]

Journal of Physics: Conference Series, 2018
Machine learning is an important applied research area in particle physics, beginning with applications to high-level physics analysis in the 1990s and 2000s, followed by an explosion of applications in particle and event identification and ...
K. Albertsson, Piero Altoe, D. Anderson, M. Andrews, Juan Pedro Araque Espinosa, A. Aurisano, L. Basara, A. Bevan, W. Bhimji, D. Bonacorsi, P. Calafiura, M. Campanelli, Louis Capps, F. Carminati, S. Carrazza, T. Childers, E. Coniavitis, Kyle Cranmer, C. David, D. Davis, Javier Mauricio Duarte, M. Erdmann, J. Eschle, A. Farbin, M. Feickert, N. Castro, C. Fitzpatrick, M. Floris, A. Forti, J. Garra-Tico, J. Gemmler, M. Girone, P. Glaysher, S. Gleyzer, V. Gligorov, T. Golling, Jonas Graw, L. Gray, D. Greenwood, T. Hacker, J. Harvey, B. Hegner, Lukas Heinrich, B. Hooberman, J. Junggeburth, M. Kagan, M. Kane, K. Kanishchev, P. Karpinski, Z. Kassabov, Gaurav Kaul, D. Kcira, T. Keck, A. Klimentov, J. Kowalkowski, L. Kreczko, A. Kurepin, R. Kutschke, Valentin Kuznetsov, Nicolas Köhler, I. Lakomov, K. Lannon, M. Lassnig, A. Limosani, Gilles Louppe, A. Mangu, P. Mato, N. Meenakshi, H. Meinhard, D. Menasce, L. Moneta, S. Moortgat, M. Neubauer, H. Newman, Hans Pabst, Michela Paganini, M. Paulini, G. Perdue, Uzziel Perez, A. Picazio, J. Pivarski, H. Prosper, F. Psihas, A. Radovic, R. Reece, Aurelius Rinkevicius, Eduardo Rodrigues, J. Rorie, D. Rousseau, A. Sauers, S. Schramm, A. Schwartzman, H. Severini, P. Seyfert, Filip Siroky, Konstantin Skazytkin, M. Sokoloff, G. Stewart, B. Stienen, I. Stockdale, G. Strong, S. Thais, K. Tomko, E. Upfal, E. Usai, A. Ustyuzhanin, M. Vala, S. Vallecorsa, M. Verzetti, X. Vilasís-Cardona, J. Vlimant, I. Vukotic, Sean Wang, G. Watts, Michael Williams, Wenjing Wu, Stefan Wunsch, O. Zapata   +117 more
semanticscholar   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Data Preservation and Long Term Analysis in High Energy Physics

, 2012
Several important and unique experimental high-energy physics programmes at a variety of facilities are coming to an end, including those at HERA, the B-factories and the Tevatron.
South, David M.
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

High-energy hadron physics at future facilities

, 2007
We outline several directions for future investigations of the three-dimensional structure of nucleon, including multiparton correlations, color transparency, and branching processes at hadron colliders and at hadron factories. We also find evidence that
Abe, Affolder, Aitala, Azimov, Brodsky, Brodsky, Clasie, Diakonov, Fadin, Farrar, Frankfurt, Frankfurt, Frankfurt, Frankfurt, Frankfurt, Frankfurt, Mark Strikman, Strikman, Strikman, Strikman, White   +20 more
core   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Maximal Entanglement in High Energy Physics [PDF]

, 2017
We analyze how maximal entanglement is generated at the fundamental level in QED by studying correlations between helicity states in tree-level scattering processes at high energy.
Alba Cervera-Lierta, J. Latorre, J. Rojo, L. Rottoli   +3 more
semanticscholar   +1 more source