Results 111 to 120 of about 459,795 (288)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi +5 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
Results of a low power ice protection system test and a new method of imaging data analysis [PDF]
Tests were conducted on a BF Goodrich De-Icing System's Pneumatic Impulse Ice Protection (PIIP) system in the NASA Lewis Icing Research Tunnel (IRT). Characterization studies were done on shed ice particle size by changing the input pressure and cycling ...
Bond, Thomas H. +2 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit +11 more
wiley +1 more source
On the influence of artificially distorted images in firearm detection performance using deep learning [PDF]
PeerJ Computer ScienceDetecting people carrying firearms in outdoor or indoor scenes usually identifies (or avoids) potentially dangerous situations. Nevertheless, the automatic detection of these weapons can be greatly affected by the scene conditions.
Patricia Corral-Sanz +3 more
doaj +2 more sources
Demonstration of a pulsing liquid hydrogen/liquid oxygen thruster [PDF]
Successful operation of a pulsing liquid hydrogen/liquid oxygen attitude control propulsion system thruster (1250 lb sub f) at cryogenic inlet conditions while maintaining high specific impulse and low impulse bit capability was demonstrated. Significant
Choenman, L., Herr, P. N.
core +1 more source
Arthritis Care &Research, EarlyView.Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo +88 more
wiley +1 more source
EnergiesThis study delves into the response characteristics of core grounding current signals in power transformers across different operating conditions, aiming to enhance the accuracy of transformer condition assessment.
Li Wang +7 more
doaj +1 more source
Unhappiness after Hurricane Katrina [PDF]
In August, September and October of 2005, the Monthly Surveys of Consumers fielded by the University of Michigan included questions about the happiness of a nationally representative sample of U.S. adults. The date of each interview is known.
Fumio Ohtake +3 more
core
High Health Care Utilization Preceding Diagnosis With Juvenile Idiopathic Arthritis
Arthritis Care &Research, EarlyView.Objective Although early diagnosis improves long‐term outcomes, patients with juvenile idiopathic arthritis (JIA) often experience prolonged, circuitous paths to diagnosis. To inform diagnostic improvement, we sought to characterize health care utilization in the year preceding diagnosis. Methods We identified 10,021 patients with an incident diagnosis
Anna Costello +5 more
wiley +1 more source