Results 41 to 50 of about 21,868,902 (293)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Impulse Characteristics of Various Soil-Enhancement Material Mixtures

Applied Sciences
Many studies have demonstrated that a reduction in ground impedance value occurs under high-impulse current magnitudes, due to the ionisation process in soil.
Fazlul Aman, Usman Muhammad, Normiza Mohamad Nor, Haziah Abdul Hamid   +3 more
doaj   +1 more source

Potentials' distribution in high resistivity soil around extended grounding electrodes [PDF]

Vestnik MGTU, 2016
The potential distribution in high resistivity soil around extended grounding electrodes has been described in the paper. The high-voltage polygon has been developed for experimental investigation.
Ivonin V. V.
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Lightning Impulse Ageing of HDPE

, 2009
This work is concerned with the hypothesis that lightning impulses can lead to accelerated ageing of extruded polymeric cables. The behaviour of an insulation material when suffering lightning impulses is different from that for DC or power frequency ...
Dao, N L, Swingler, S G, Lewin, P L
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Algorithms for Modules Implementing Amplitude Impulse Modulation

Вестник Дагестанского государственного технического университета: Технические науки
Objective. The aim of the study is to develop algorithms and approaches for effective synthesis of controllers in automated control systems (ACS) that utilize amplitude impulse modulation (AIM), as well as address the shortcomings of classical synthesis ...
N. L. Grechkin, E. Yu. Vataeva
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Performance of different earthing configurations under high impulse conditions

, 2019
The effectiveness of earthing systems is a major concern in today‘s power system applications. Earthing system is very important for an electrical installation system as stated in BS 7671, MS IEC 60364, IEEE Std 81-2012 and IEEE Std 802000; as it ...
Mohamed Yunus, Mohamed Shahriman
core   +1 more source

How Financial Stress Can Impact Fiscal and Monetary Policies: Threshold VAR Analysis for Brazilian Economy

Econometrics
This study examines economic policy responses in Brazil during periods of financial stress, with a particular emphasis on the dynamics of both the impulse and rule components of fiscal policy.
Roberta Moreira Wichmann, Werley Cordeiro, João F. Caldeira   +2 more
doaj   +1 more source