Results 51 to 60 of about 20,768,812 (286)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Impulse Characteristics of Various Soil-Enhancement Material Mixtures
Applied SciencesMany studies have demonstrated that a reduction in ground impedance value occurs under high-impulse current magnitudes, due to the ionisation process in soil.
Fazlul Aman +3 more
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Potentials' distribution in high resistivity soil around extended grounding electrodes [PDF]
Vestnik MGTU, 2016 The potential distribution in high resistivity soil around extended grounding electrodes has been described in the paper. The high-voltage polygon has been developed for experimental investigation.
Ivonin V. V.
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Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Lightning Impulse Ageing of HDPE
, 2009 This work is concerned with the hypothesis that lightning impulses can lead to accelerated ageing of extruded polymeric cables. The behaviour of an insulation material when suffering lightning impulses is different from that for DC or power frequency ...
Dao, N L, Swingler, S G, Lewin, P L
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A dual Stage ion engine for high impulse missions
, 2012 In this paper, the applicability of dual stage ion optics and in particular of the so-called dual stage ion engine to high power, high specific impulse missions will be evaluated. First, the performance limits of conventional two gridded ion engines (GIE)
Coletti, M., Gabriel, S.B.
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FEBS Open Bio, EarlyView.Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia +9 more
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Algorithms for Modules Implementing Amplitude Impulse Modulation
Вестник Дагестанского государственного технического университета: Технические наукиObjective. The aim of the study is to develop algorithms and approaches for effective synthesis of controllers in automated control systems (ACS) that utilize amplitude impulse modulation (AIM), as well as address the shortcomings of classical synthesis ...
N. L. Grechkin, E. Yu. Vataeva
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
Lightning Impulse Ageing of HV Cable Insulation
, 2009 Lightning impulses can lead to accelerated ageing of extruded cables. Electrical behaviour of a dielectric material when experiencing a lightning impulse is different to that for DC or power frequency applied voltages.
Dao, N L, Swingler, S G, Lewin, P L
core +1 more source